Human CSH1 Active Protein – Cat# MBS141538

Placental Lactogen (CSH1) Human Active Protein

Name: CSH1 Active Protein; Placental Lactogen; Human; MyBioSource
Brand: MyBioSource
SKU: MBS141538
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS141538

Placental Lactogen is a polypeptide hormone that is produced by the Syncytiotrophoblasts of the Placenta.Placental Lactogen has both GH and Prolactin activities on growth, lactation, and luteal steroid production. In women, placental lactogen secretion begins… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Placental Lactogen (CSH1), Active Protein

Full Product Name

Recombinant Human Placental Lactogen, Sf9

Product Gene Name

CSH1 active protein

Product Synonym Names

Placental Lactogen; Sf9; Placental Lactogen Sf9; Human; Placental Lactogen Human Recombinant; Sf9; Chorionic Somatomammotropin Hormone 1; CSH1; Choriomammotropin; Lactogen; CSH2; PL; CSA; CSMT; FLJ75407

Sequence

VQTVPLSRLF DHAMLQAHRA HQLAIDTYQE FEETYIPKDQ KYSFLHDSQT SFCFSDSIPT PSNMEETQQK SNLELLRISL LLIESWLEPV RFLRSMFANN LVYDTSDSDD YHLLKDLEEG IQTLMGRLED GSRRTGQILK QTYSKFDTNS HNHDALLKNY GLLYCFRKDM DKVETFLRMV QCRSVEGSCG FHHHHHH

Host

Sf9, Baculovirus cells

Form/Format

Sterile filtered colorless solution.
The Placental Lactogen solution (0.25mg/ml) contains 30% Glycerol and Phosphate-Buffered Saline (pH7.4).

Purity/Purification

Greater than 90.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks.
Store, frozen at -20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

Molecular Weight

25,020 Da

Chromosome Location

Chromosome: 17; NC_000017.10 (61972268..61974021, complement). Location: 17q24.2

OMIM

150200

3D Structure

ModBase 3D Structure for P0DML2

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Determined by cell proliferation assay using Nb2-11 Rat lymphoma cells. ED50 range for this effect is <= 0.8ng/ml.

Product Categories/Family for CSH1 active protein

CYTOKINES AND GROWTH FACTORS

Other Notes

Small volumes of CSH1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CSH1 purchase

MBS141538 is an active protein targeting CSH1. Also known as Recombinant Human Placental Lactogen, Sf9. Host: Sf9, Baculovirus cells.

Additional Details

NCBI/Uniprot data below describe general gene information for CSH1. It may not necessarily be applicable to this product.

NCBI GI #

190034

NCBI GeneID

1442

NCBI Accession #

AAA98621.1

UniProt Primary Accession #

P0DML2

UniProt Secondary Accession #

Q0VDB1; Q14407

UniProt Related Accession #

P01243

NCBI Official Full Name

placental lactogen

NCBI Official Synonym Full Names

chorionic somatomammotropin hormone 1 (placental lactogen)

NCBI Official Symbol

CSH1

NCBI Official Synonym Symbols

PL; CSA; CS-1; CSMT; hCS-A

UniProt Protein Name

Chorionic somatomammotropin hormone 1

UniProt Synonym Protein Names

Lactogen; Placental lactogen; PL

Protein Family

Chorionic somatomammotropin hormone

UniProt Gene Name

CSH1

UniProt Synonym Gene Names

Choriomammotropin; PL

UniProt Entry Name

CSH1_HUMAN

NCBI Protein Information

chorionic somatomammotropin hormone; choriomammotropin; placental lactogen; chorionic somatomammotropin A

NCBI Summary for CSH1

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome. [provided by RefSeq, Jul 2008]

UniProt Comments for CSH1

CSH1: Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. Belongs to the somatotropin/prolactin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17q24.2

Cellular Component: extracellular region

Molecular Function: metal ion binding; hormone activity

Research Articles on CSH1

1. results are consistent with a pleiotropic effect of placental hGH/CSH genes at the maternal-fetal interface relating to the regulation of fetal growth and the risk of affected maternal metabolism.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CSH1 active protein

Reference Product	PubMed Publications
PSG4 active protein	>2 publications with CSH1 and PSG4
PSG3 active protein	>1 publications with CSH1 and PSG3

Pathways associated with CSH1 active protein

Products by Pathway	Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Growth Hormone Receptor Signaling Pathway antibodies	Growth Hormone Receptor Signaling Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Nuclear Signaling By ERBB4 Pathway antibodies	Nuclear Signaling By ERBB4 Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram

Diseases associated with CSH1 active protein

Disease Name	Pubmed Publications
Pregnancy Complications Antibodies	>8 publications with CSH1 and Pregnancy Complications
Silver-Russell Syndrome Antibodies	>5 publications with CSH1 and Silver-Russell Syndrome
Immune System Diseases Antibodies	>2 publications with CSH1 and Immune System Diseases
Breast Neoplasms Antibodies	>2 publications with CSH1 and Breast Neoplasms
Cardiovascular Diseases Antibodies	>2 publications with CSH1 and Cardiovascular Diseases
Myocardial Ischemia Antibodies	>1 publications with CSH1 and Myocardial Ischemia
Adenocarcinoma Antibodies	>1 publications with CSH1 and Adenocarcinoma
Ovarian Neoplasms Antibodies	>1 publications with CSH1 and Ovarian Neoplasms
Disease Models, Animal Antibodies	>1 publications with CSH1 and Disease Models, Animal
Nervous System Diseases Antibodies	>1 publications with CSH1 and Nervous System Diseases

Organs/Tissues associated with CSH1 active protein

Organ/Tissue Name	Pubmed Publications
Placenta Antibodies	>23 publications with CSH1 and Placenta
Embryonic Tissue Antibodies	>10 publications with CSH1 and Embryonic Tissue
Blood Antibodies	>9 publications with CSH1 and Blood
Uterus Antibodies	>5 publications with CSH1 and Uterus
Brain Antibodies	>4 publications with CSH1 and Brain
Heart Antibodies	>2 publications with CSH1 and Heart
Kidney Antibodies	>1 publications with CSH1 and Kidney
Lung Antibodies	>1 publications with CSH1 and Lung
Bladder Antibodies	>1 publications with CSH1 and Bladder
Vascular Antibodies	>1 publications with CSH1 and Vascular