Human CA1 Active Protein – Cat# MBS141573

Carbonic Anhydrase-1 (CA1) Human Active Protein

Name: CA1 Active Protein; Carbonic Anhydrase-1; Human; MyBioSource
Brand: MyBioSource
SKU: MBS141573
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS141573

CA, also known as carbonic anhydrase is an enzyme. Its main function revolves around the CO2 + H2O HCO3- + H+ (conversion of carbon dioxide to bicarbonate & protons). CA has a zinc ion in its active site. The main function of CA is to keep acid-base balance… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Carbonic Anhydrase-1 (CA1), Active Protein

Full Product Name

Recombinant Human Carbonic Anhydrase-1, BioActive

Product Gene Name

CA1 active protein

Product Synonym Names

CA1 Active; CA1 Human Active; Carbonic Anhydrase-1 Human Recombinant; BioActive; CA1; CA-I; CAB

Sequence

MGSSHHHHHH SSGLVPRGSH MASPDWGYDD KNGPEQWSKL YPIANGNNQS PVDIKTSETK HDTSLKPISV SYNPATAKEI INVGHSFHVN FEDNDNRSVL KGGPFSDSYR LFQFHFHWGS TNEHGSEHTV DGVKYSAELH VAHWNSAKYS SLAEAASKAD GLAVIGVLMK VGEANPKLQK VLDALQAIKT KGKRAPFTNF DPSTLLPSSL DFWTYPGSLT HPPLYESVTW IICKESISVS SEQLAQFRSL LSNVEGDNAV PMQHNNRPTQ PLKGRTVRAS F

Host

E Coli

Form/Format

Sterile filtered clear solution.
CA1 Human protein (1mg/ml) is formulated in 20mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 10% glycerol.

Purity/Purification

Greater than 95.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks.
Store, frozen at -20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

Molecular Weight

28,870 Da

Chromosome Location

Chromosome: 8; NC_000008.10 (86240458..86290342, complement). Location: 8q21.2

OMIM

114800

3D Structure

ModBase 3D Structure for P00915

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Specific activity is >300pmol/min/ug, and is defined as the amount of enzyme that hydrolyze 1.0pmole of 4-nitrophenyl acetate to 4-nitrophenol per minute at pH8.0 at 37 degree C.

Product Categories/Family for CA1 active protein

ENZYMES

Other Notes

Small volumes of CA1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CA1 purchase

MBS141573 is an active protein targeting CA1. Also known as Recombinant Human Carbonic Anhydrase-1, BioActive. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CA1. It may not necessarily be applicable to this product.

NCBI GI #

192447430

NCBI GeneID

759

NCBI Accession #

NP_001122301.1

UniProt Primary Accession #

P00915

UniProt Related Accession #

P00915

GenBank Nucleotide #

NM_001128829.2

NCBI Official Full Name

carbonic anhydrase 1

NCBI Official Synonym Full Names

carbonic anhydrase I

NCBI Official Symbol

CA1

NCBI Official Synonym Symbols

CAB; CA-I; Car1

UniProt Protein Name

Carbonic anhydrase 1

UniProt Synonym Protein Names

Carbonate dehydratase I; Carbonic anhydrase B; CAB; Carbonic anhydrase I

Protein Family

Actin

UniProt Gene Name

CA1

UniProt Synonym Gene Names

CAB; CA-I

UniProt Entry Name

CAH1_HUMAN

NCBI Protein Information

carbonic anhydrase 1; carbonic anhydrase B; carbonic dehydratase; carbonate dehydratase I

NCBI Summary for CA1

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA1 is closely linked to CA2 and CA3 genes on chromosome 8, and it encodes a cytosolic protein which is found at the highest level in erythrocytes. Variants of this gene have been described in some populations. Multiple alternatively spliced variants, encoding the same protein, have been identified. Transcript variants of CA1 utilizing alternative polyA_sites have been described in literature. [provided by RefSeq, Sep 2009]

UniProt Comments for CA1

CA1: Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea. Belongs to the alpha-carbonic anhydrase family.

Protein type: EC 4.2.1.1; Lyase; Energy Metabolism - nitrogen

Chromosomal Location of Human Ortholog: 8q21.2

Cellular Component: cytosol

Molecular Function: carbonate dehydratase activity; zinc ion binding

Biological Process: bicarbonate transport; one-carbon compound metabolic process

Research Articles on CA1

1. The new prognostic biomarkers GRP78, Fructose-bisphosphate Aldolase A (ALDOA), Carbonic Anhydrase I (CA1) and Peptidyl-prolyl cis-trans isomerase A or Cyclophilin A (PPIA)) provided good survival prediction for TNM stage I-IV patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CA1 active protein

Products by Pathway	Pathway Diagram
C-MYB Transcription Factor Network Pathway antibodies	C-MYB Transcription Factor Network Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
O2/CO2 Exchange In Erythrocytes Pathway antibodies	O2/CO2 Exchange In Erythrocytes Pathway Diagram
Reversible Hydration Of Carbon Dioxide Pathway antibodies	Reversible Hydration Of Carbon Dioxide Pathway Diagram
Uptake Of Carbon Dioxide And Release Of Oxygen By Erythrocytes Pathway antibodies	Uptake Of Carbon Dioxide And Release Of Oxygen By Erythrocytes Pathway Diagram
Uptake Of Oxygen And Release Of Carbon Dioxide By Erythrocytes Pathway antibodies	Uptake Of Oxygen And Release Of Carbon Dioxide By Erythrocytes Pathway Diagram

Diseases associated with CA1 active protein

Disease Name	Pubmed Publications
Central Nervous System Diseases Antibodies	>5903 publications with CA1 and Central Nervous System Diseases
Brain Ischemia Antibodies	>3250 publications with CA1 and Brain Ischemia
Cardiovascular Diseases Antibodies	>3129 publications with CA1 and Cardiovascular Diseases
Memory Disorders Antibodies	>793 publications with CA1 and Memory Disorders
Nerve Degeneration Antibodies	>697 publications with CA1 and Nerve Degeneration
Neurobehavioral Manifestations Antibodies	>634 publications with CA1 and Neurobehavioral Manifestations
Learning Disorders Antibodies	>615 publications with CA1 and Learning Disorders
Brain Injuries Antibodies	>376 publications with CA1 and Brain Injuries
Necrosis Antibodies	>361 publications with CA1 and Necrosis
Cognition Disorders Antibodies	>311 publications with CA1 and Cognition Disorders

Organs/Tissues associated with CA1 active protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>18703 publications with CA1 and Brain
Blood Antibodies	>1838 publications with CA1 and Blood
Intestine Antibodies	>29 publications with CA1 and Intestine
Bone Marrow Antibodies	>19 publications with CA1 and Bone Marrow
Stomach Antibodies	>11 publications with CA1 and Stomach
Connective Tissue Antibodies	>8 publications with CA1 and Connective Tissue
Uncharacterized Tissue Antibodies	>2 publications with CA1 and Uncharacterized Tissue