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Fibroblast Activation Alpha (FAP) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS141580

DPP4 also called adenosine deaminase complexing protein-2, and T-cell activation antigen CD26 is a serine exopeptidase and complex enzyme that is expressed on the surface of most cell types. DPPIV is an intrinsic membrane glycoprotein and a serine… More details

$250 / 0.002 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Fibroblast Activation Alpha (FAP), Active Protein
Full Product Name
Recombinant Human Fibroblast Activation Protein Alpha
Product Gene Name
FAP active protein
Product Synonym Names
FAP; FAP Human; Fibroblast Activation Protein Alpha Human Recombinant; Prolyl endopeptidase FAP; 170 kDa melanoma membrane-bound gelatinase; Dipeptidyl peptidase FAP; Fibroblast activation protein alpha; FAPalpha; Gelatine degradation protease FAP; Integral membrane serine protease; Post-proline cleaving enzyme; Serine integral membrane protease; Surface-expressed protease; Seprase; SIMP; FAP
Sequence
ADPLRPSRVH NSEENTMRAL TLKDILNGTF SYKTFFPNWI SGQEYLHQSA DNNIVLYNIE TGQSYTILSN RTMKSVNASN YGLSPDRQFV YLESDYSKLW RYSYTATYYI YDLSNGEFVR GNELPRPIQY LCWSPVGSKL AYVYQNNIYL KQRPGDPPFQ ITFNGRENKI FNGIPDWVYE EEMLATKYAL WWSPNGKFLA YAEFNDTDIP VIAYSYYGDE QYPRTINIPY PKAGAKNPVV RIFIIDTTYP AYVGPQEVPV PAMIASSDYY FSWLTWVTDE RVCLQWLKRV QNVSVLSICD FREDWQTWDC PKTQEHIEES RTGWAGGFFV STPVFSYDAI SYYKIFSDKD GYKHIHYIKD TVENAIQITS GKWEAINIFR VTQDSLFYSS NEFEEYPGRR NIYRISIGSY PPSKKCVTCH LRKERCQYYT ASFSDYAKYY ALVCYGPGIP ISTLHDGRTD QEIKILEENK ELENALKNIQ LPKEEIKKLE VDEITLWYKM ILPPQFDRSK KYPLLIQVYG GPCSQSVRSV FAVNWISYLA SKEGMVIALV DGRGTAFQGD KLLYAVYRKL GVYEVEDQIT AVRKFIEMGF IDEKRIAIWG WSYGGYVSSL ALASGTGLFK CGIAVAPVSS WEYYASVYTE RFMGLPTKDD NLEHYKNSTV MARAEYFRNV DYLLIHGTAD DNVHFQNSAQ IAKALVNAQV DFQAMWYSDQ NHGLSGLSTN HLYTHMTHFL KQCFSLSDHH HHHH
Host
Sf9, Baculovirus cells
Form/Format
Sterile filtered colorless solution.
The FAP solution (0.25mg/ml) contains 20% Glycerol and Phosphate-Buffered Saline (pH7.4).
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks.
Store, frozen at -20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Molecular Weight
87,713 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (163027200..163100045, complement). Location: 2q23
OMIM
600403
3D Structure
ModBase 3D Structure for Q12884
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
Specific activity >5,000pmol/min/ug. It is defined by the amount of enzyme that hydrolyzes 1.0 pmole of ZGP-AMC per minute at pH7.5, at 37 degree C.

Product Categories/Family for FAP active protein

ENZYMES

Other Notes

Small volumes of FAP active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FAP purchase

MBS141580 is an active protein targeting FAP. Also known as Recombinant Human Fibroblast Activation Protein Alpha. Host: Sf9, Baculovirus cells.

Additional Details

NCBI/Uniprot data below describe general gene information for FAP. It may not necessarily be applicable to this product.

NCBI GI #
16933540
NCBI GeneID
2191
NCBI Accession #
NP_004451.2
UniProt Primary Accession #
Q12884
UniProt Secondary Accession #
O00199; Q53TP5; Q86Z29; Q99998; Q9UID4
UniProt Related Accession #
Q12884
GenBank Nucleotide #
NM_004460.2
NCBI Official Full Name
seprase
NCBI Official Synonym Full Names
fibroblast activation protein, alpha
NCBI Official Symbol
FAP
NCBI Official Synonym Symbols
FAPA; DPPIV
UniProt Protein Name
Seprase
UniProt Synonym Protein Names
170 kDa melanoma membrane-bound gelatinase; Fibroblast activation protein alpha; Integral membrane serine protease
Protein Family
Prolyl endopeptidase
UniProt Gene Name
FAP
UniProt Entry Name
SEPR_HUMAN
NCBI Protein Information
seprase; integral membrane serine protease; 170 kDa melanoma membrane-bound gelatinase

NCBI Summary for FAP

The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. [provided by RefSeq, Jul 2008]
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UniProt Comments for FAP

FAP: In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers. Belongs to the peptidase S9B family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.14.5; Protease; EC 3.4.21.26; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q23

Cellular Component: extracellular space; focal adhesion; cell surface; lamellipodium; apical part of cell; cytoplasm; plasma membrane; integral to membrane

Molecular Function: integrin binding; protein dimerization activity; peptidase activity; protein binding; protein homodimerization activity; protease binding; dipeptidyl-peptidase activity; serine-type peptidase activity; metalloendopeptidase activity; serine-type endopeptidase activity; endopeptidase activity

Biological Process: proteolysis involved in cellular protein catabolic process; endothelial cell migration; angiogenesis; proteolysis; cell adhesion; regulation of fibrinolysis
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Research Articles on FAP

1. High intratumoral expression of fibroblast activation protein is associated with colorectal cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FAP active protein

 Reference Product  PubMed Publications
 DPP4 active protein  >16 publications with FAP and DPP4

Diseases associated with FAP active protein

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >552 publications with FAP and Carcinoma
 Adenocarcinoma Antibodies  >247 publications with FAP and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >148 publications with FAP and Cardiovascular Diseases
 Hypertrophy Antibodies  >97 publications with FAP and Hypertrophy
 Inflammation Antibodies  >78 publications with FAP and Inflammation
 Thyroid Diseases Antibodies  >65 publications with FAP and Thyroid Diseases
 Precancerous Conditions Antibodies  >43 publications with FAP and Precancerous Conditions
 Necrosis Antibodies  >39 publications with FAP and Necrosis
 Liver Failure Antibodies  >34 publications with FAP and Liver Failure
 Hyperplasia Antibodies  >27 publications with FAP and Hyperplasia

Organs/Tissues associated with FAP active protein

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >386 publications with FAP and Intestine
 Liver Antibodies  >379 publications with FAP and Liver
 Vascular Antibodies  >157 publications with FAP and Vascular
 Muscle Antibodies  >140 publications with FAP and Muscle
 Stomach Antibodies  >133 publications with FAP and Stomach
 Eye Antibodies  >126 publications with FAP and Eye
 Brain Antibodies  >104 publications with FAP and Brain
 Thyroid Antibodies  >103 publications with FAP and Thyroid
 Skin Antibodies  >89 publications with FAP and Skin
 Lung Antibodies  >79 publications with FAP and Lung
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