Mouse mMMP2 Recombinant Protein – Cat# MBS141591

Matrix Metalloproteinase-2 (mMMP2) Mouse Recombinant Protein

Name: mMMP2 Recombinant Protein; Matrix Metalloproteinase-2; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS141591
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS141591

MMP-2 or gelatinase A, is secreted by fibroblasts, cardiomyocytes, and myofibroblasts. MMP-2 has a broad feild of substrates, that contain elastin, collagen, fibroblast growth factor, endothelin, MMP-9, plasminogen, MMP-13 and TGF-beta, pointing towards bread… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Matrix Metalloproteinase-2 (mMMP2), Recombinant Protein

Full Product Name

Recombinant Mouse Matrix Metalloproteinase-2

Product Gene Name

mMMP2 recombinant protein

Product Synonym Names

mMMP2; MMP2 Mouse; Matrix Metalloproteinase-2 Mouse Recombinant; 72 kDa type IV collagenase; 72 kDa gelatinase; Gelatinase A; Matrix metalloproteinase-2; MMP-2; TBE-1; MMP2; CLG4A; CLG4; MONA; MMP-II

Sequence

ADPEFAPSPI IKFPGDVAPK TDKELAVQYL NTFYGCPKES CNLFVLKDTL KKMQKFFGLP QTGDLDQNTI ETMRKPRCGN PDVANYNFFP RKPKWDKNQI TYRIIGYTPD LDPETVDDAF ARALKVWSDV TPLRFSRIHD GEADIMINFG RWEHGDGYPF DGKDGLLAHA FAPGTGVGGD SHFDDDELWT LGEGQVVRVK YGNADGEYCK FPFLFNGREY SSCTDTGRSD GFLWCSTTYN FEKDGKYGFC PHEALFTMGG NADGQPCKFP FRFQGTSYNS CTTEGRTDGY RWCGTTEDYD RDKKYGFCPE TAMSTVGGNS EGAPCVFPFT FLGNKYESCT SAGRNDGKVW CATTTNYDDD RKWGFCPDQG YSLFLVAAHE FGHAMGLEHS QDPGALMAPI YTYTKNFRLS HDDIKGIQEL YGPSPDADTD TGTGPTPTLG PVTPEICKQD IVFDGIAQIR GEIFFFKDRF IWRTVTPRDK PTGPLLVATF WPELPEKIDA VYEAPQEEKA VFFAGNEYWV YSASTLERGY PKPLTSLGLP PDVQQVDAAF NWSKNKKTYI FAGDKFWRYN EVKKKMDPGF PKLIADSWNA IPDNLDAVVD LQGGGHSYFF KGAYYLKLEN QSLKSVKFGS IKSDWLGCHH HHHH

Host

Sf9, Baculovirus cells

Form/Format

Sterile filtered colorless solution
The MMP2 solution (0.25 mg/ml) contains 10% Glycerol and Phosphate-Buffered Saline (pH7.4).

Purity/Purification

Greater than 85.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks.
Store, frozen at -20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

Molecular Weight

65,883 Da

3D Structure

ModBase 3D Structure for P33434

Product Categories/Family for mMMP2 recombinant protein

ENZYMES

Other Notes

Small volumes of mMMP2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for mMMP2 purchase

MBS141591 is a recombinant protein targeting mMMP2. Also known as Recombinant Mouse Matrix Metalloproteinase-2. Host: Sf9, Baculovirus cells.

Additional Details

NCBI/Uniprot data below describe general gene information for mMMP2. It may not necessarily be applicable to this product.

NCBI GI #

461766

NCBI GeneID

17390

NCBI Accession #

P33434.1

UniProt Primary Accession #

P33434

UniProt Related Accession #

P33434

NCBI Official Full Name

72 kDa type IV collagenase

NCBI Official Synonym Full Names

matrix metallopeptidase 2

NCBI Official Symbol

Mmp2

NCBI Official Synonym Symbols

GelA; Clg4a; MMP-2

UniProt Protein Name

72 kDa type IV collagenase

UniProt Synonym Protein Names

72 kDa gelatinase; Gelatinase A; Matrix metalloproteinase-2; MMP-2

Protein Family

Matrix metalloproteinase

UniProt Gene Name

Mmp2

UniProt Synonym Gene Names

MMP-2

UniProt Entry Name

MMP2_MOUSE

NCBI Protein Information

72 kDa type IV collagenase; gelatinase A; 72kD gelatinase; 72kDa gelatinase; 72 kDa gelatinase; 72kD type IV collagenase; 72kDa type IV collagenase; matrix metalloproteinase 2; matrix metalloproteinase-2

UniProt Comments for mMMP2

MMP2: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Interacts (via the C-terminal hemopexin-like domains- containing region) with the integrin alpha-V/beta-3; the interaction promotes vascular invasion in angiogenic vessels and melamoma cells. Interacts (via the C-terminal PEX domain) with TIMP2 (via the C-terminal); the interaction inhibits the degradation activity. Interacts with GSK3B. Aspirin appears to inhibit expression. Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate. Inhibited by histatin-3 1/24 (histatin-5). Belongs to the peptidase M10A family.

Protein type: Protease; Secreted; Apoptosis; Cell development/differentiation; EC 3.4.24.24; Secreted, signal peptide; Motility/polarity/chemotaxis

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; sarcomere; membrane; mitochondrion; cytoplasm; plasma membrane; extracellular region; nucleus

Molecular Function: peptidase activity; zinc ion binding; hydrolase activity; metallopeptidase activity; metal ion binding; metalloendopeptidase activity; fibronectin binding

Biological Process: response to drug; cell migration; intramembranous ossification; positive regulation of apoptosis; tissue remodeling; negative regulation of cell adhesion; proteolysis; axon regeneration in the peripheral nervous system; blood vessel maturation; negative regulation of vasoconstriction; collagen catabolic process; response to hydrogen peroxide; ovarian follicle development; response to estrogen stimulus; skeletal morphogenesis; response to mechanical stimulus; positive regulation of innate immune response; response to hypoxia; response to oxidative stress; angiogenesis; embryo implantation; positive regulation of cell migration

Research Articles on mMMP2

1. mPGES-1 was essential for MMP-2 and MMP-9 up-regulation that enhances tumor metastasis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with mMMP2 recombinant protein

Products by Pathway	Pathway Diagram
Activation Of Matrix Metalloproteinases Pathway antibodies	Activation Of Matrix Metalloproteinases Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Bladder Cancer Pathway antibodies	Bladder Cancer Pathway Diagram
Bladder Cancer Pathway antibodies	Bladder Cancer Pathway Diagram
Collagen Degradation Pathway antibodies	Collagen Degradation Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
EPH-Ephrin Signaling Pathway antibodies	EPH-Ephrin Signaling Pathway Diagram
EPH-ephrin Mediated Repulsion Of Cells Pathway antibodies	EPH-ephrin Mediated Repulsion Of Cells Pathway Diagram
Estrogen Signaling Pathway antibodies	Estrogen Signaling Pathway Diagram

Diseases associated with mMMP2 recombinant protein

Disease Name	Pubmed Publications
Neoplasm Invasiveness Antibodies	>527 publications with mMMP2 and Neoplasm Invasiveness
Neoplasm Metastasis Antibodies	>417 publications with mMMP2 and Neoplasm Metastasis
Inflammation Antibodies	>304 publications with mMMP2 and Inflammation
Disease Progression Antibodies	>209 publications with mMMP2 and Disease Progression
Heart Diseases Antibodies	>191 publications with mMMP2 and Heart Diseases
Necrosis Antibodies	>185 publications with mMMP2 and Necrosis
Breast Neoplasms Antibodies	>170 publications with mMMP2 and Breast Neoplasms
Bone Diseases Antibodies	>104 publications with mMMP2 and Bone Diseases
Colorectal Neoplasms Antibodies	>101 publications with mMMP2 and Colorectal Neoplasms
Aortic Diseases Antibodies	>94 publications with mMMP2 and Aortic Diseases

Organs/Tissues associated with mMMP2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>362 publications with mMMP2 and Muscle
Lung Antibodies	>312 publications with mMMP2 and Lung
Bone Antibodies	>234 publications with mMMP2 and Bone
Heart Antibodies	>219 publications with mMMP2 and Heart
Brain Antibodies	>199 publications with mMMP2 and Brain
Connective Tissue Antibodies	>140 publications with mMMP2 and Connective Tissue
Kidney Antibodies	>132 publications with mMMP2 and Kidney
Skin Antibodies	>130 publications with mMMP2 and Skin
Eye Antibodies	>99 publications with mMMP2 and Eye
Prostate Antibodies	>81 publications with mMMP2 and Prostate