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Phosphogluconate Dehydrogenase (PGD) Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS141593

6PGD is the 2nd dehydrogenase in the pentose phosphate shift. Pentose is crucial for the biosynthesis of nucleic acid. The pentose phosphate cycle is a prominent source of NADPH. 6PGD deficiency is mostly asymptomatic, and the inheritance of this deasis is… More details

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Product Overview

Online Datasheet in PDF
Product Name
Phosphogluconate Dehydrogenase (PGD), Active Protein
Full Product Name
Recombinant Human Phosphogluconate Dehydrogenase, Active
Product Gene Name
PGD active protein
Product Synonym Names
PGD Active; PGD Human Active; Phosphogluconate Dehydrogenase Active Human Recombinant; EC 11144; 6PGD; PGDH; 6-phosphogluconate dehydrogenase decarboxylating; PGD
Sequence
MGSSHHHHHH SSGLVPRGSH MAQADIALIG LAVMGQNLIL NMNDHGFVVC AFNRTVSKVD DFLANEAKGT KVVGAQSLKE MVSKLKKPRR IILLVKAGQA VDDFIEKLVP LLDTGDIIID GGNSEYRDTT RRCRDLKAKG ILFVGSGVSG GEEGARYGPS LMPGGNKEAW PHIKTIFQGI AAKVGTGEPC CDWVGDEGAG HFVKMVHNGI EYGDMQLICE AYHLMKDVLG MAQDEMAQAF EDWNKTELDS FLIEITANIL KFQDTDGKHL LPKIRDSAGQ KGTGKWTAIS ALEYGVPVTL IGEAVFARCL SSLKDERIQA SKKLKGPQKF QFDGDKKSFL EDIRKALYAS KIISYAQGFM LLRQAATEFG WTLNYGGIAL MWRGGCIIRS VFLGKIKDAF DRNPELQNLL LDDFFKSAVE NCQDSWRRAV STGVQAGIPM PCFTTALSFY DGYRHEMLPA SLIQAQRDYF GAHTYELLAK PGQFIHTNWT GHGGTVSSSS YNA
Host
E Coli
Form/Format
Sterile filtered colorless solution.
The PGD solution (1mg/ml) contains 10% Glycerol, 1mM DTT, 0.1M NaCl, and 20mM Tris-HCl buffer (pH8.0).
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks.
Store, frozen at -20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Molecular Weight
53,140 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (10459085..10480201). Location: 1p36.22
OMIM
172200
3D Structure
ModBase 3D Structure for P52209
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
Specific activity is >10unit/mg. One unit will oxidize 1.0 umole of 6-phospho-D-gluconate to D-ribulose 5- phosphate per minute at pH8.0 at 25 degree C, in the presence of beta-NADP.

Product Categories/Family for PGD active protein

ENZYMES

Other Notes

Small volumes of PGD active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PGD purchase

MBS141593 is an active protein targeting PGD. Also known as Recombinant Human Phosphogluconate Dehydrogenase, Active. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PGD. It may not necessarily be applicable to this product.

NCBI GI #
40068518
NCBI GeneID
5226
NCBI Accession #
NP_002622.2
UniProt Primary Accession #
P52209
UniProt Secondary Accession #
Q9BWD8; A8K2Y9
UniProt Related Accession #
P52209
GenBank Nucleotide #
NM_002631.2
NCBI Official Full Name
6-phosphogluconate dehydrogenase, decarboxylating
NCBI Official Synonym Full Names
phosphogluconate dehydrogenase
NCBI Official Symbol
PGD
NCBI Official Synonym Symbols
6PGD
UniProt Protein Name
6-phosphogluconate dehydrogenase, decarboxylating
Protein Family
Putative 6-phosphogluconate dehydrogenase
UniProt Gene Name
PGD
UniProt Synonym Gene Names
PGDH
UniProt Entry Name
6PGD_HUMAN
NCBI Protein Information
6-phosphogluconate dehydrogenase, decarboxylating

NCBI Summary for PGD

6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. [provided by RefSeq, Jul 2008]
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UniProt Comments for PGD

PGD: an oxidative carboxylase that catalyses the decarboxylating reduction of 6-phosphogluconate into ribulose 5-phosphate in the presence of NADP. This reaction is a component of the hexose mono-phosphate shunt and pentose phosphate pathways.

Protein type: Oxidoreductase; Carbohydrate Metabolism - pentose phosphate pathway; Other Amino Acids Metabolism - glutathione; EC 1.1.1.44

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: nucleus; cytosol

Molecular Function: phosphogluconate dehydrogenase (decarboxylating) activity; NADP binding

Biological Process: pentose-phosphate shunt; pentose-phosphate shunt, oxidative branch; carbohydrate metabolic process; pathogenesis; D-gluconate metabolic process; pentose biosynthetic process
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Research Articles on PGD

1. Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PGD active protein

 Products by Pathway  Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Carbohydrates Pathway antibodies  Metabolism Of Carbohydrates Pathway Diagram
 Pentose Phosphate Pathway antibodies  Pentose Phosphate Pathway Diagram
 Pentose Phosphate Pathway antibodies  Pentose Phosphate Pathway Diagram
 Pentose Phosphate Pathway antibodies  Pentose Phosphate Pathway Diagram
 Pentose Phosphate Pathway (Pentose Phosphate Cycle) antibodies  Pentose Phosphate Pathway (Pentose Phosphate Cycle) Diagram
 Pentose Phosphate Pathway (Pentose Phosphate Cycle) antibodies  Pentose Phosphate Pathway (Pentose Phosphate Cycle) Diagram
 Pentose Phosphate Pathway (hexose Monophosphate Shunt) antibodies  Pentose Phosphate Pathway (hexose Monophosphate Shunt) Diagram

Diseases associated with PGD active protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >231 publications with PGD and Nervous System Diseases
 Inflammation Antibodies  >216 publications with PGD and Inflammation
 Neoplasms Antibodies  >154 publications with PGD and Neoplasms
 Brain Diseases Antibodies  >105 publications with PGD and Brain Diseases
 Anemia Antibodies  >92 publications with PGD and Anemia
 Muscular Diseases Antibodies  >43 publications with PGD and Muscular Diseases
 Necrosis Antibodies  >43 publications with PGD and Necrosis
 Kidney Diseases Antibodies  >40 publications with PGD and Kidney Diseases
 Drug Toxicity Antibodies  >33 publications with PGD and Drug Toxicity
 Breast Neoplasms Antibodies  >29 publications with PGD and Breast Neoplasms

Organs/Tissues associated with PGD active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >687 publications with PGD and Blood
 Lung Antibodies  >201 publications with PGD and Lung
 Brain Antibodies  >161 publications with PGD and Brain
 Vascular Antibodies  >106 publications with PGD and Vascular
 Heart Antibodies  >104 publications with PGD and Heart
 Bone Antibodies  >93 publications with PGD and Bone
 Muscle Antibodies  >87 publications with PGD and Muscle
 Uterus Antibodies  >72 publications with PGD and Uterus
 Bone Marrow Antibodies  >69 publications with PGD and Bone Marrow
 Skin Antibodies  >68 publications with PGD and Skin
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