Human SORD Active Protein – Cat# MBS141596

Sorbitol Dehydrogenase (SORD) Human Active Protein

Name: SORD Active Protein; Sorbitol Dehydrogenase; Human; MyBioSource
Brand: MyBioSource
SKU: MBS141596
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS141596

SORD, also referred to as sorbitol dehydrogenase, belongs to the zinc-containing alcohol dehydrogenase family. It is widely produced. The lens of the eyeand the kidney are the protein highest production areas. Zinc-dependent interconversion of polyols, like… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Sorbitol Dehydrogenase (SORD), Active Protein

Full Product Name

Recombinant Human Sorbitol Dehydrogenase

Product Gene Name

SORD active protein

Product Synonym Names

SORD; SORD Human; Sorbitol Dehydrogenase Human Recombinant; EC 11114; SORD1; SORD; L-iditol 2-dehydrogenase; DHSO; Sorbitol Dehydrogenase;SDH; (R;R)-butanediol dehydrogenase; L-iditol 2-dehydrogenase; Polyol dehydrogenase; Ribitol dehydrogenase; RDH; Xylitol dehydrogenase; XDH

Sequence

MAAAAKPNNL SLVVHGPGDL RLENYPIPEP GPNEVLLRMH SVGICGSDVH YWEYGRIGNF IVKKPMVLGH EASGTVEKVG SSVKHLKPGD RVAIEPGAPR ENDEFCKMGR YNLSPSIFFC ATPPDDGNLC RFYKHNAAFC YKLPDNVTFE EGALIEPLSV GIHACRRGGV TLGHKVLVCG AGPIGMVTLL VAKAMGAAQV VVTDLSATRL SKAKEIGADL VLQISKESPQ EIARKVEGQL GCKPEVTIEC TGAEASIQAG IYATRSGGTL VLVGLGSEMT TVPLLHAAIR EVDIKGVFRY CNTWPVAISM LASKSVNVKP LVTHRFPLEK ALEAFETFKK GLGLKIMLKC DPSDQNP

Host

E Coli

Form/Format

Sterile filtered colorless solution
The SORD solution (0.5mg/ml) contains 10% glycerol, 20mM Tris-HCl buffer (pH8.5) and 1mM DTT.

Purity/Purification

Greater than 90.0% as determined by SDS-PAGE

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks.
Store, frozen at -20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

Molecular Weight

357

OMIM

182500

3D Structure

ModBase 3D Structure for Q00796

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Specific activity >15unit/mg. Defined by the amount of enzyme that catalyze the reduction 1.0 umole of D-fructose to D-sorbitol per minute at pH7.5 at 37 degree C.

Product Categories/Family for SORD active protein

ENZYMES

Other Notes

Small volumes of SORD active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SORD purchase

MBS141596 is an active protein targeting SORD. Also known as Recombinant Human Sorbitol Dehydrogenase. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for SORD. It may not necessarily be applicable to this product.

NCBI GI #

292495088

NCBI GeneID

6652

NCBI Accession #

Q00796.4

UniProt Primary Accession #

Q00796

UniProt Secondary Accession #

Q16682; Q9UMD6; B2R655; B7Z3A6; J3JZZ5

UniProt Related Accession #

Q00796

NCBI Official Full Name

Sorbitol dehydrogenase

NCBI Official Synonym Full Names

sorbitol dehydrogenase

NCBI Official Symbol

SORD

NCBI Official Synonym Symbols

SORD1; HEL-S-95n

UniProt Protein Name

Sorbitol dehydrogenase

UniProt Synonym Protein Names

L-iditol 2-dehydrogenase

Protein Family

PTS system sorbose-specific EIID component

UniProt Gene Name

SORD

UniProt Entry Name

DHSO_HUMAN

NCBI Protein Information

sorbitol dehydrogenase; L-iditol 2-dehydrogenase; epididymis secretory sperm binding protein Li 95n

NCBI Summary for SORD

Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010]

UniProt Comments for SORD

SORD: Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm. Belongs to the zinc-containing alcohol dehydrogenase family.

Protein type: EC 1.1.1.14; Oxidoreductase; Carbohydrate Metabolism - fructose and mannose

Chromosomal Location of Human Ortholog: 15q15.3

Cellular Component: extracellular space; membrane; mitochondrial membrane

Molecular Function: zinc ion binding; L-iditol 2-dehydrogenase activity; carbohydrate binding; NAD binding

Biological Process: sperm motility; L-xylitol metabolic process; L-xylitol catabolic process; glucose metabolic process; fructose biosynthetic process; sorbitol catabolic process

Research Articles on SORD

1. One of the most striking changes involved sorbitol dehydrogenase, a key enzyme in the polyol pathway. Validation studies revealed dramatically increased sorbitol dehydrogenase concentrations and activity in adenomas and cancer cell lines, along with important changes in the expression of other enzymes in the same (AKR1B1) and related (KHK) pathways.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SORD active protein

Reference Product	PubMed Publications
KHK active protein	>1 publications with SORD and KHK
HK1 active protein	>1 publications with SORD and HK1

Pathways associated with SORD active protein

Products by Pathway	Pathway Diagram
Fructose And Mannose Metabolism Pathway antibodies	Fructose And Mannose Metabolism Pathway Diagram
Fructose And Mannose Metabolism Pathway antibodies	Fructose And Mannose Metabolism Pathway Diagram
Glucuronate Pathway (uronate Pathway) antibodies	Glucuronate Pathway (uronate Pathway) Diagram
Glucuronate Pathway (uronate Pathway) antibodies	Glucuronate Pathway (uronate Pathway) Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Pentose And Glucuronate Interconversions Pathway antibodies	Pentose And Glucuronate Interconversions Pathway Diagram
Pentose And Glucuronate Interconversions Pathway antibodies	Pentose And Glucuronate Interconversions Pathway Diagram
Polyol Pathway antibodies	Polyol Pathway Diagram
Sorbitol Degradation I Pathway antibodies	Sorbitol Degradation I Pathway Diagram

Diseases associated with SORD active protein

Disease Name	Pubmed Publications
Brain Diseases Antibodies	>3 publications with SORD and Brain Diseases
Adenocarcinoma Antibodies	>2 publications with SORD and Adenocarcinoma
Mental Disorders Antibodies	>2 publications with SORD and Mental Disorders
Liver Diseases Antibodies	>2 publications with SORD and Liver Diseases
Liver Cirrhosis Antibodies	>1 publications with SORD and Liver Cirrhosis
Carcinoma, Hepatocellular Antibodies	>1 publications with SORD and Carcinoma, Hepatocellular
Hyperglycemia Antibodies	>1 publications with SORD and Hyperglycemia
Liver Neoplasms Antibodies	>1 publications with SORD and Liver Neoplasms
Fatty Liver Antibodies	>1 publications with SORD and Fatty Liver
Kidney Diseases Antibodies	>1 publications with SORD and Kidney Diseases

Organs/Tissues associated with SORD active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>11 publications with SORD and Blood
Brain Antibodies	>7 publications with SORD and Brain
Liver Antibodies	>4 publications with SORD and Liver
Eye Antibodies	>3 publications with SORD and Eye
Kidney Antibodies	>3 publications with SORD and Kidney
Vascular Antibodies	>2 publications with SORD and Vascular
Muscle Antibodies	>2 publications with SORD and Muscle
Larynx Antibodies	>1 publications with SORD and Larynx
Testis Antibodies	>1 publications with SORD and Testis
Thyroid Antibodies	>1 publications with SORD and Thyroid