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Methylmalonate-Semialdehyde Dehydrogenase [Acylating], Mitochondrial (ALDH6A1) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1416024

This protein belongs to the aldehyde dehydrogenases family of proteins. This enzyme plays a role in the valine and pyrimidine catabolic pathways. The product of this gene, a mitochondrial methylmalonate semialdehyde dehydrogenase, catalyzes the irreversible… More details

$1305 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (Aldh6a1), Recombinant Protein
Full Product Name
Recombinant Mouse Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (Aldh6a1)
Product Gene Name
Aldh6a1 recombinant protein
Product Synonym Gene Name
Aldh6a1
Sequence
SSSSVPTVKL FIDGKFVESK SDKWIDIHNP ATNEVVGRVP QSTKAEMDAA VESCKRAFPA WADTSILSRQ QVLLRYQQLI KENLKEIARL ITLEQGKTLA DAEGDVFRGL QVVEHACSVT SLMLGETMPS ITKDMDLYSY RLPLGVCAGI APFNFPAMIP LWMFPMAMVC GNTFLMKPSE RVPGATMLLA KLLQDSGAPD GTLNIIHGQH DAVNFICDHP DIKAISFVGS NQAGEYIFER GSRNGKRVQA NMGAKNHGVV MPDANKENTL NQLVGAAFGA AGQRCMALST AILVGEAKKW LPELVDRAKN LRVNAGDQPG ADLGPLITPQ AKERVCNLID SGTKEGASIL LDGRRIKVKG YENGNFVGPT IISNVKPSMT CYKEEIFGPV LVVLETETLD EAIKIVNDNP YGNGTAIFTT NGATARKYAH MVDVGQVGVN VPIPVPLPMF SFTGSRSSFR GDTNFYGKQG IQFYTQLKTI TSQWKEEDAT LSSPAVVMPT MGR
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
57,916 Da
Sequence Positions
33-535, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q9EQ20
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Aldh6a1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Aldh6a1 purchase

MBS1416024 is a recombinant protein targeting Aldh6a1. Also known as Recombinant Mouse Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (Aldh6a1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Aldh6a1. It may not necessarily be applicable to this product.

NCBI GI #
19527258
NCBI GeneID
104776
NCBI Accession #
NP_598803.1
UniProt Primary Accession #
Q9EQ20
UniProt Secondary Accession #
Q3TDA2; Q8CIB4
UniProt Related Accession #
Q9EQ20
GenBank Nucleotide #
NM_134042.3
NCBI Official Full Name
methylmalonate-semialdehyde dehydrogenase
NCBI Official Synonym Full Names
aldehyde dehydrogenase family 6, subfamily A1
NCBI Official Symbol
Aldh6a1
NCBI Official Synonym Symbols
Mmsdh; 1110038I05Rik
UniProt Protein Name
Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
UniProt Synonym Protein Names
Aldehyde dehydrogenase family 6 member A1
UniProt Gene Name
Aldh6a1
UniProt Synonym Gene Names
MMSDH; Malonate-semialdehyde dehydrogenase [acylating]
NCBI Protein Information
methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial

NCBI Summary for Aldh6a1

This gene encodes a member of the aldehyde dehydrogenase protein family. The encoded enzyme is a mitochondrial methylmalonate semialdehyde dehydrogenase that plays a role in the valine and pyrimidine catabolic pathways. This enzyme catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Mutations in the human gene result in Methylmalonate Semialdehyde Dehydrogenase Deficiency, characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
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UniProt Comments for Aldh6a1

Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA ().

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Aldh6a1 recombinant protein

 Reference Product  PubMed Publications
 Hibadh recombinant protein  >1 publications with Aldh6a1 and Hibadh

Pathways associated with Aldh6a1 recombinant protein

 Products by Pathway  Pathway Diagram
 Branched-chain Amino Acid Catabolism Pathway antibodies  Branched-chain Amino Acid Catabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Malonate Semialdehyde Pathway, Propanoyl-CoA => Acetyl-CoA antibodies  Malonate Semialdehyde Pathway, Propanoyl-CoA => Acetyl-CoA Diagram
 Malonate Semialdehyde Pathway, Propanoyl-CoA => Acetyl-CoA antibodies  Malonate Semialdehyde Pathway, Propanoyl-CoA => Acetyl-CoA Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Propanoate Metabolism Pathway antibodies  Propanoate Metabolism Pathway Diagram
 Propanoate Metabolism Pathway antibodies  Propanoate Metabolism Pathway Diagram
 Valine, Leucine And Isoleucine Degradation Pathway antibodies  Valine, Leucine And Isoleucine Degradation Pathway Diagram

Diseases associated with Aldh6a1 recombinant protein

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >2 publications with Aldh6a1 and Carcinoma
 Neoplasms Antibodies  >2 publications with Aldh6a1 and Neoplasms
 Liver Diseases Antibodies  >1 publications with Aldh6a1 and Liver Diseases
 Adenocarcinoma Antibodies  >1 publications with Aldh6a1 and Adenocarcinoma
 Kidney Neoplasms Antibodies  >1 publications with Aldh6a1 and Kidney Neoplasms
 Liver Neoplasms Antibodies  >1 publications with Aldh6a1 and Liver Neoplasms
 Kidney Diseases Antibodies  >1 publications with Aldh6a1 and Kidney Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with Aldh6a1 and Carcinoma, Hepatocellular

Organs/Tissues associated with Aldh6a1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >2 publications with Aldh6a1 and Liver
 Brain Antibodies  >1 publications with Aldh6a1 and Brain
 Kidney Antibodies  >1 publications with Aldh6a1 and Kidney
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