SARS Associated Coronavirus SARS Active Protein – Cat# MBS141666

SARS Associated Coronavirus Spike (SARS) SARS Associated Coronavirus Active Protein

Name: SARS Active Protein; SARS Associated Coronavirus; MyBioSource
Brand: MyBioSource
SKU: MBS141666
Price: 285 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS141666

SARS Spike produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 1188 amino acids (14-1195 aa) and having a molecular mass of 131.9kDa. SARS Spike is fused to a 6 amino acid His tag at C-terminus and purified by proprietary… More details

$285 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SARS Associated Coronavirus Spike, Active Protein

Full Product Name

Recombinant SARS Associated Coronavirus Spike (14-1195 a.a.)

Product Gene Name

SARS active protein

Product Synonym Names

SARS Spike (14-1195); SARS Spike (14-1195); SARS Associated Coronavirus Spike (14-1195 a.a.) Recombinant; Spike glycoprotein; S glycoprotein; Peplomer protein; E2 glycoprotein precursor; Severe acute repiratory Syndrome-related Coronavirus; SARS; SRAS-CoV; SARS-CoV1; E2

Sequence

SDLDRCTTFD DVQAPNYTQH TSSMRGVYYP DEIFRSDTLY LTQDLFLPFY SNVTGFHTIN HTFGNPVIPF KDGIYFAATE KSNVVRGWVF GSTMNNKSQS VIIINNSTNV VIRACNFELC DNPFFAVSKP MGTQTHTMIF DNAFNCTFEY ISDAFSLDVS EKSGNFKHLR EFVFKNKDGF LYVYKGYQPI DVVRDLPSGF NTLKPIFKLP LGINITNFRA ILTAFSPAQD IWGTSAAAYF VGYLKPTTFM LKYDENGTIT DAVDCSQNPL AELKCSVKSF EIDKGIYQTS NFRVVPSGDV VRFPNITNLC PFGEVFNATK FPSVYAWERK KISNCVADYS VLYNSTFFST FKCYGVSATK LNDLCFSNVY ADSFVVKGDD VRQIAPGQTG VIADYNYKLP DDFMGCVLAW NTRNIDATST GNYNYKYRYL RHGKLRPFER DISNVPFSPD GKPCTPPALN CYWPLNDYGF YTTTGIGYQP YRVVVLSFEL LNAPATVCGP KLSTDLIKNQ CVNFNFNGLT GTGVLTPSSK RFQPFQQFGR DVSDFTDSVR DPKTSEILDI SPCAFGGVSV ITPGTNASSE VAVLYQDVNC TDVSTAIHAD QLTPAWRIYS TGNNVFQTQA GCLIGAEHVD TSYECDIPIG AGICASYHTV SLLRSTSQKS IVAYTMSLGA DSSIAYSNNT IAIPTNFSIS ITTEVMPVSM AKTSVDCNMY ICGDSTECAN LLLQYGSFCT QLNRALSGIA AEQDRNTREV FAQVKQMYKT PTLKYFGGFN FSQILPDPLK PTKRSFIEDL LFNKVTLADA GFMKQYGECL GDINARDLIC AQKFNGLTVL PPLLTDDMIA AYTAALVSGT ATAGWTFGAG AALQIPFAMQ MAYRFNGIGV TQNVLYENQK QIANQFNKAI SQIQESLTTT STALGKLQDV VNQNAQALNT LVKQLSSNFG AISSVLNDIL SRLDKVEAEV QIDRLITGRL QSLQTYVTQQ LIRAAEIRAS ANLAATKMSE CVLGQSKRVD FCGKGYHLMS FPQAAPHGVV FLHVTYVPSQ ERNFTTAPAI CHEGKAYFPR EGVFVFNGTS WFITQRNFFS PQIITTDNTF VSGNCDVVIG IINNTVYDPL QPELDSFKEE LDKYFKNHTS PDVDLGDISG INASVVNIQK EIDRLNEVAK NLNESLIDLQ ELGKYEQYIK WPHHHHHH

Host

Sf9, Baculovirus cells

Form/Format

Sterile filtered colorless solution.
The SARS Spike (14-1195) solution (0.25mg/ml) contains Phosphate-Buffered Saline (pH7.4) and 10% Glycerol.

Purity/Purification

Greater than 85.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4°C if entire vial will be used within 2-4 weeks.
Freeze at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

Molecular Weight

139,125 Da

Sequence Positions

14-1195aa

3D Structure

ModBase 3D Structure for P59594

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Measured by its binding ability in a functional ELISA with Human ACE-2 (CAT# MBS141590).

Dry Ice Shipment

Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Product Categories/Family for SARS active protein

VIRAL ANTIGENS- SARS PROTEINS

Other Notes

Small volumes of SARS active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SARS purchase

MBS141666 is an active protein targeting SARS. Also known as Recombinant SARS Associated Coronavirus Spike (14-1195 a.a.). Host: Sf9, Baculovirus cells.

Additional Details

NCBI/Uniprot data below describe general gene information for SARS. It may not necessarily be applicable to this product.

NCBI GI #

30173397

NCBI GeneID

1489668

NCBI Accession #

P59594.1

UniProt Primary Accession #

P59594

UniProt Secondary Accession #

Q6QU82; Q7T696; Q7TA19; Q7TFA2; Q7TFB1; Q80BV6

NCBI Official Full Name

Spike glycoprotein

NCBI Official Symbol

NCBI Official Synonym Symbols

UniProt Protein Name

Spike glycoprotein

UniProt Synonym Protein Names

E2; Peplomer proteinCleaved into the following 2 chains:Spike protein S1; Spike protein S2

Protein Family

HTH-type transcriptional regulator

UniProt Gene Name

UniProt Synonym Gene Names

S glycoprotein

UniProt Entry Name

SPIKE_CVHSA

NCBI Protein Information

E2 glycoprotein precursor; spike glycoprotein

UniProt Comments for SARS

S1 attaches the virion to the cell membrane by interacting with human ACE2 and CLEC4M/DC-SIGNR, initiating the infection. Binding to the receptor and internalization of the virus into the endosomes of the host cell probably induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.

Research Articles on SARS

1. Unlike the pH-independent retroviral fusion proteins, SARS-CoV E2 is stable over a wide pH range, supporting its ability to fuse at both the plasma membrane and endosome.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SARS active protein

Reference Product	PubMed Publications
FLNA active protein	>12 publications with SARS and FLNA

Pathways associated with SARS active protein

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