Mouse mC 10 Active Protein – Cat# MBS142016

C-10 (mC 10) Mouse Active Protein

Name: mC 10 Active Protein; C-10; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS142016
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS142016

Description: C-10 Mouse Recombinant produced in E Coli is a single,non-glycosylated, polypeptide chain containing 95 amino acids and having a molecular mass of 10.7kDa.The CCL6 is purified by proprietary chromatographic techniques.Introduction: Chemokine (C-C… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

C-10 (mC 10), Active Protein

Full Product Name

Recombinant Mouse C-10 (CCL6)

Product Gene Name

mC 10 active protein

Product Synonym Names

C 10 Mouse; C-10 Mouse Recombinant (CCL6); Small inducible cytokine A6; CCL6; C10 protein; c10; MRP-1; Scya6; chemokine (C-C motif) ligand 6

Sequence

GLIQEIEKED RRYNPPIIHQ GFQDTSSDCC FSYATQIPCK RFIYYFPTSG GCIKPGIIFI SRRGTQVCAD PSDRRVQRCL STLKQGPRSG NKVIA

Host

E Coli

Form/Format

CCL6 Mouse was lyophilized from a 0.2 um filtered concentrated solution in 1xPBS, pH 7.4.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Preparation and Storage

Lyophilized C10 protein although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CCL6 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Molecular Weight

12,984 Da

3D Structure

ModBase 3D Structure for P27784

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility

It is recommended to reconstitute the lyophilized C10 protein in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Biological Activity

The Biological activity was determined by its ability to chemoattract human CCR1 transfected BaF3 mouse proB cells using a concentration range of 0.05-0.25 ug/ml.

Product Categories/Family for mC 10 active protein

Chemokines

Other Notes

Small volumes of mC 10 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for mC 10 purchase

MBS142016 is an active protein targeting mC 10. Also known as Recombinant Mouse C-10 (CCL6). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for mC 10. It may not necessarily be applicable to this product.

NCBI GI #

6677883

NCBI GeneID

20305

NCBI Accession #

NP_033165.1

UniProt Primary Accession #

P27784

UniProt Secondary Accession #

Q3U3W3; Q5QNW1; Q99M24; Q9D830

UniProt Related Accession #

P27784

GenBank Nucleotide #

NM_009139.3

NCBI Official Full Name

C-C motif chemokine 6

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 6

NCBI Official Symbol

Ccl6

NCBI Official Synonym Symbols

c10; MRP-1; Scya6

UniProt Protein Name

C-C motif chemokine 6

UniProt Synonym Protein Names

Protein C10; Small-inducible cytokine A6Cleaved into the following 2 chains:CCL6(22-95); CCL6(23-95)

UniProt Gene Name

Ccl6

UniProt Synonym Gene Names

C10; Scya6

UniProt Entry Name

CCL6_MOUSE

NCBI Protein Information

C-C motif chemokine 6; CC chemokine C10; small inducible cytokine A6; small-inducible cytokine A6

UniProt Comments for mC 10

CCL6: Shows chemotactic activity for monocytes, resting T- lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23. Belongs to the intercrine beta (chemokine CC) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine activity; cytokine activity

Biological Process: immune response; chemotaxis

Research Articles on mC 10

1. Mice lacking RXRalpha in myeloid cells exhibit reduced levels of CCL6 and CCL9, impaired recruitment of leukocytes to sites of inflammation, and lower susceptibility to sepsis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with mC 10 active protein

Products by Pathway	Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram

Diseases associated with mC 10 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>26 publications with mC 10 and Inflammation
Disease Models, Animal Antibodies	>16 publications with mC 10 and Disease Models, Animal
Lung Diseases Antibodies	>11 publications with mC 10 and Lung Diseases
Fibrosis Antibodies	>9 publications with mC 10 and Fibrosis
Asthma Antibodies	>8 publications with mC 10 and Asthma
Respiratory Hypersensitivity Antibodies	>8 publications with mC 10 and Respiratory Hypersensitivity
Necrosis Antibodies	>6 publications with mC 10 and Necrosis
Nervous System Diseases Antibodies	>5 publications with mC 10 and Nervous System Diseases
Liver Diseases Antibodies	>4 publications with mC 10 and Liver Diseases
Lung Neoplasms Antibodies	>2 publications with mC 10 and Lung Neoplasms

Organs/Tissues associated with mC 10 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>38 publications with mC 10 and Blood
Lung Antibodies	>18 publications with mC 10 and Lung
Liver Antibodies	>7 publications with mC 10 and Liver
Intestine Antibodies	>7 publications with mC 10 and Intestine
Bone Antibodies	>5 publications with mC 10 and Bone
Lymph Node Antibodies	>4 publications with mC 10 and Lymph Node
Bone Marrow Antibodies	>4 publications with mC 10 and Bone Marrow
Spleen Antibodies	>4 publications with mC 10 and Spleen
Muscle Antibodies	>4 publications with mC 10 and Muscle
Kidney Antibodies	>3 publications with mC 10 and Kidney