Human GRO b Active Protein – Cat# MBS142018

GRO-Beta/MIP-2 (GRO b) Human Active Protein

Name: GRO b Active Protein; GRO-Beta/MIP-2; Human; MyBioSource
Brand: MyBioSource
SKU: MBS142018
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS142018

Description: GRO-Beta Human Recombinant produced in E Coli is a single,non-glycosylated, polypeptide chain containing 73 amino acids and having a molecular mass of 7908 Dalton. The CXCL2 is purified by proprietary chromatographic techniques.Introduction:… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GRO-beta/MIP-2 (GRO b), Active Protein

Full Product Name

Recombinant Human GRO-beta/MIP-2 (CXCL2)

Product Gene Name

GRO b active protein

Product Synonym Names

GRO b Human; GRO-Beta Human Recombinant (CXCL2); Macrophage inflammatory protein 2-alpha; MIP2-alpha; CXCL2; Growth- regulated protein beta; Gro-beta; chemokine (C-X-C motif) ligand 2; GRO2; GROb; MIP2; MIP2A; SCYB2; MGSA-b; MIP-2a; CINC-2a; MGSA beta

Sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Pro-Le u-Ala-Thr

Host

E Coli

Form/Format

The protein was lyophilized with no additives.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Preparation and Storage

Lyophilized CXCL2 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CXCL2 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Molecular Weight

11,389 Da

OMIM

139110

3D Structure

ModBase 3D Structure for P19875

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility

It is recommended to reconstitute the lyophilized GRO-beta Human in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Biological Activity

The Biological activity is calculated by its ability to chemoattract CXCR2 transfected 293 cells using 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.

Product Categories/Family for GRO b active protein

Chemokines; GRO

Other Notes

Small volumes of GRO b active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GRO b purchase

MBS142018 is an active protein targeting GRO b. Also known as Recombinant Human GRO-beta/MIP-2 (CXCL2). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GRO b. It may not necessarily be applicable to this product.

NCBI GI #

4504155

NCBI GeneID

2920

NCBI Accession #

NP_002080.1

UniProt Primary Accession #

P19875

UniProt Secondary Accession #

Q6FGD6; Q9UPB8

UniProt Related Accession #

P19875

GenBank Nucleotide #

NM_002089.3

NCBI Official Full Name

C-X-C motif chemokine 2

NCBI Official Synonym Full Names

chemokine (C-X-C motif) ligand 2

NCBI Official Symbol

CXCL2

NCBI Official Synonym Symbols

GRO2; GROb; MIP2; MIP2A; SCYB2; MGSA-b; MIP-2a; CINC-2a

UniProt Protein Name

C-X-C motif chemokine 2

UniProt Synonym Protein Names

Growth-regulated protein beta; Gro-beta; Macrophage inflammatory protein 2-alpha; MIP2-alpha

UniProt Gene Name

CXCL2

UniProt Synonym Gene Names

GRO2; GROB; MIP2A; SCYB2; Gro-beta; MIP2-alpha; HSF

UniProt Entry Name

CXCL2_HUMAN

NCBI Protein Information

C-X-C motif chemokine 2; GRO2 oncogene; MGSA beta; MIP2-alpha; gro-beta; growth-regulated protein beta; macrophage inflammatory protein 2-alpha; melanoma growth stimulatory activity beta

NCBI Summary for GRO b

This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]

UniProt Comments for GRO b

CXCL2: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; chemokine activity; CXCR chemokine receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; response to molecule of bacterial origin; positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; immune response; inflammatory response; chemotaxis; regulation of cell proliferation

Research Articles on GRO b

1. CXCL2 has antimicrobial activity against E. coli and S. aureus.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GRO b active protein

Reference Product	PubMed Publications
CXCL1 active protein	>569 publications with GRO b and CXCL1
CCL4 active protein	>188 publications with GRO b and CCL4
CXCR2 active protein	>153 publications with GRO b and CXCR2
CCL5 active protein	>127 publications with GRO b and CCL5
CXCL3 active protein	>100 publications with GRO b and CXCL3
CCL20 active protein	>78 publications with GRO b and CCL20
CCR1 active protein	>26 publications with GRO b and CCR1
CXCR1 active protein	>25 publications with GRO b and CXCR1
CCR5 active protein	>23 publications with GRO b and CCR5
CCL19 active protein	>7 publications with GRO b and CCL19

Pathways associated with GRO b active protein

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokines And Inflammatory Response Pathway antibodies	Cytokines And Inflammatory Response Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram

Diseases associated with GRO b active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>1033 publications with GRO b and Inflammation
Necrosis Antibodies	>652 publications with GRO b and Necrosis
Lung Diseases Antibodies	>391 publications with GRO b and Lung Diseases
Disease Models, Animal Antibodies	>366 publications with GRO b and Disease Models, Animal
Lung Injury Antibodies	>265 publications with GRO b and Lung Injury
Pneumonia Antibodies	>175 publications with GRO b and Pneumonia
Reperfusion Injury Antibodies	>115 publications with GRO b and Reperfusion Injury
Wounds and Injuries Antibodies	>98 publications with GRO b and Wounds and Injuries
Edema Antibodies	>96 publications with GRO b and Edema
Skin Diseases Antibodies	>84 publications with GRO b and Skin Diseases

Organs/Tissues associated with GRO b active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1077 publications with GRO b and Blood
Lung Antibodies	>637 publications with GRO b and Lung
Liver Antibodies	>206 publications with GRO b and Liver
Bone Antibodies	>171 publications with GRO b and Bone
Bone Marrow Antibodies	>141 publications with GRO b and Bone Marrow
Brain Antibodies	>124 publications with GRO b and Brain
Intestine Antibodies	>117 publications with GRO b and Intestine
Kidney Antibodies	>98 publications with GRO b and Kidney
Eye Antibodies	>57 publications with GRO b and Eye
Pancreas Antibodies	>43 publications with GRO b and Pancreas