Mouse mIP 10 Active Protein – Cat# MBS142043

Ip-10 (mIP 10) Mouse Active Protein

Name: mIP 10 Active Protein; Ip-10; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS142043
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS142043

Description: IP-10 Mouse Recombinant produced in E Coli is a single,non-glycosylated, polypeptide chain containing 77 amino acids and having a molecular mass of 8701 Dalton. The IP-10 is purified by proprietary chromatographic techniques.Introduction:… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IP-10 (mIP 10), Active Protein

Full Product Name

Recombinant Mouse IP-10 (CXCL10)

Product Gene Name

mIP 10 active protein

Product Synonym Names

IP 10 Mouse; IP-10 Mouse Recombinant (CXCL10); Small inducible cytokine B10; CXCL10; 10 kDa interferon-gamma-induced protein; Gamma-IP10; IP-10; chemokine (C-X-C motif) ligand 10; C7; IFI10; INP10; crg-2; mob-1; SCYB10; gIP-10

Sequence

IPLARTVRCN CIHIDDGPVR MRAIGKLEII PASLSCPRVE IIATMKKNDE QRCLNPESKT IKNLMKAFSQ KRSKRAP

Host

E Coli

Form/Format

IP-10 was lyophilized from a 0.2 um filtered concentrated solution in 1xPBS, pH 7.4.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Preparation and Storage

Lyophilized IP-10 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CXCL10 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Molecular Weight

10,789 Da

3D Structure

ModBase 3D Structure for P17515

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility

It is recommended to reconstitute the lyophilized IP-10 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Protein Content

Protein quantitation was carried out by two independent methods:1. UV spectroscopy at 280 nm using the absorbency value of 0.02 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics). 2. Analysis by RP-HPLC, using a standard solution of IP-10 as a Reference Standard.

Biological Activity

Determined by its ability to chemoattract hCXCR3/HEK293 cells using a concentration range of 100.0-500.0 ng/ml.

Product Categories/Family for mIP 10 active protein

Chemokines; IP-10 (CXCL10)

Other Notes

Small volumes of mIP 10 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for mIP 10 purchase

MBS142043 is an active protein targeting mIP 10. Also known as Recombinant Mouse IP-10 (CXCL10). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for mIP 10. It may not necessarily be applicable to this product.

NCBI GI #

10946576

NCBI GeneID

15945

NCBI Accession #

NP_067249.1

UniProt Primary Accession #

P17515

UniProt Related Accession #

P17515

GenBank Nucleotide #

NM_021274.2

NCBI Official Full Name

C-X-C motif chemokine 10

NCBI Official Synonym Full Names

chemokine (C-X-C motif) ligand 10

NCBI Official Symbol

Cxcl10

NCBI Official Synonym Symbols

C7; IP10; CRG-2; INP10; IP-10; Ifi10; mob-1; Scyb10; gIP-10

UniProt Protein Name

C-X-C motif chemokine 10

UniProt Synonym Protein Names

10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; C7; Interferon-gamma induced protein CRG-2; Small-inducible cytokine B10

UniProt Gene Name

Cxcl10

UniProt Synonym Gene Names

Crg2; Ifi10; Inp10; Scyb10; Gamma-IP10; IP-10

UniProt Entry Name

CXL10_MOUSE

NCBI Protein Information

C-X-C motif chemokine 10; 10 kDa interferon gamma-induced protein; gamma-IP10; interferon activated gene 10; interferon-gamma induced protein CRG-2; interferon-gamma-induced protein CRG-2; small inducible cytokine B subfamily (Cys-X-Cys), member 10; small-inducible cytokine B10

UniProt Comments for mIP 10

CXCL10: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Chemokine; Secreted; Secreted, signal peptide

Cellular Component: extracellular space; cell; extracellular region; external side of plasma membrane

Molecular Function: heparin binding; CXCR3 chemokine receptor binding; chemokine activity; cytokine activity

Biological Process: response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; positive regulation of cAMP metabolic process; chemotaxis; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; positive regulation of cell proliferation; immune response; positive regulation of release of sequestered calcium ion into cytosol; inflammatory response; negative regulation of myoblast differentiation; defense response to virus; positive regulation of cell migration

Research Articles on mIP 10

1. IP-10 levels were measured to test epithelial secretion in cytic fibrosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with mIP 10 active protein

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram

Diseases associated with mIP 10 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>1158 publications with mIP 10 and Inflammation
Necrosis Antibodies	>669 publications with mIP 10 and Necrosis
Disease Models, Animal Antibodies	>337 publications with mIP 10 and Disease Models, Animal
Lung Diseases Antibodies	>332 publications with mIP 10 and Lung Diseases
Liver Diseases Antibodies	>229 publications with mIP 10 and Liver Diseases
Cardiovascular Diseases Antibodies	>169 publications with mIP 10 and Cardiovascular Diseases
Fibrosis Antibodies	>126 publications with mIP 10 and Fibrosis
Neoplasms, Experimental Antibodies	>113 publications with mIP 10 and Neoplasms, Experimental
Kidney Diseases Antibodies	>86 publications with mIP 10 and Kidney Diseases
Lung Injury Antibodies	>63 publications with mIP 10 and Lung Injury

Organs/Tissues associated with mIP 10 active protein

Organ/Tissue Name	Pubmed Publications
Lymph Node Antibodies	>159 publications with mIP 10 and Lymph Node
Spleen Antibodies	>129 publications with mIP 10 and Spleen
Bone Marrow Antibodies	>124 publications with mIP 10 and Bone Marrow
Eye Antibodies	>94 publications with mIP 10 and Eye
Intestine Antibodies	>90 publications with mIP 10 and Intestine
Embryonic Tissue Antibodies	>52 publications with mIP 10 and Embryonic Tissue
Thymus Antibodies	>52 publications with mIP 10 and Thymus
Mammary Gland Antibodies	>8 publications with mIP 10 and Mammary Gland
Epididymis Antibodies	>1 publications with mIP 10 and Epididymis