Human MIP 1a Recombinant Protein – Cat# MBS142054

Macrophage Inflammatory Protein-1 Alpha (MIP 1a) Human Recombinant Protein

Name: MIP 1a Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS142054
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS142054

Description: Macrophage Inflammatory Protein-1 alpha His Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 68 amino acids and having a molecular mass of 7820 Dalton with an amino-terminal hexahistidine tag. The… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Macrophage Inflammatory protein-1 alpha (MIP 1a), Recombinant Protein

Full Product Name

Recombinant Human Macrophage Inflammatory protein-1 alpha (CCL3), His Tag

Product Gene Name

MIP 1a recombinant protein

Product Synonym Names

MIP 1a Human, His; Macrophage Inflammatory Protein-1 Alpha Human Recombinant (CCL3), His Tag; Small inducible cytokine A3; CCL3; Macrophage inflammatory protein 1-alpha; MIP-1-alpha; Tonsillar lymphocyte LD78 alpha protein; G0/G1 switch regulatory protein 19-1; G0S19-1 protein; SIS-beta; PAT 464.1; chemokine (C-C motif) ligand 3; MIP1A; SCYA3; G0S19-1; LD78ALPHA; MIP 1a, His

Host

E Coli

Form/Format

CCL3 His-Tag is supplied in 1x PBS and 50% glycerol.
Sterile Filtered clear solution.

Purity/Purification

Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Preparation and Storage

Store CCL3 at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Please avoid freeze thaw cycles.

Molecular Weight

10,085 Da

OMIM

182283

3D Structure

ModBase 3D Structure for P10147

Product Categories/Family for MIP 1a recombinant protein

Chemokines; MIP

Other Notes

Small volumes of MIP 1a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MIP 1a purchase

MBS142054 is a recombinant protein targeting MIP 1a. Also known as Recombinant Human Macrophage Inflammatory protein-1 alpha (CCL3), His Tag. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for MIP 1a. It may not necessarily be applicable to this product.

NCBI GI #

4506843

NCBI GeneID

6348

NCBI Accession #

NP_002974.1

UniProt Primary Accession #

P10147

UniProt Related Accession #

P10147

GenBank Nucleotide #

NM_002983.2

NCBI Official Full Name

C-C motif chemokine 3

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 3

NCBI Official Symbol

CCL3

NCBI Official Synonym Symbols

MIP1A; SCYA3; G0S19-1; LD78ALPHA; MIP-1-alpha

UniProt Protein Name

C-C motif chemokine 3

UniProt Synonym Protein Names

G0/G1 switch regulatory protein 19-1; Macrophage inflammatory protein 1-alpha; MIP-1-alpha; PAT 464.1; SIS-beta; Small-inducible cytokine A3; Tonsillar lymphocyte LD78 alpha proteinMIP-1-alpha(4-69)Alternative name(s):LD78-alpha(4-69)

Protein Family

C-C motif chemokine

UniProt Gene Name

CCL3

UniProt Synonym Gene Names

G0S19-1; MIP1A; SCYA3; MIP-1-alpha

UniProt Entry Name

CCL3_HUMAN

NCBI Protein Information

C-C motif chemokine 3; G0/G1 switch regulatory protein 19-1; PAT 464.1; SIS-beta; macrophage inflammatory protein 1-alpha; small inducible cytokine A3 (homologous to mouse Mip-1a); tonsillar lymphocyte LD78 alpha protein

NCBI Summary for MIP 1a

This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010]

UniProt Comments for MIP 1a

CCL3: Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). Belongs to the intercrine beta (chemokine CC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide; Chemokine

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular space; cytoplasm; extracellular region; intracellular; cytosol

Molecular Function: identical protein binding; protein binding; CCR1 chemokine receptor binding; chemokine activity; calcium-dependent protein kinase C activity; kinase activity; protein kinase activity; CCR5 chemokine receptor binding; phospholipase activator activity; chemoattractant activity

Biological Process: positive regulation of catalytic activity; negative regulation of osteoclast differentiation; exocytosis; response to toxin; behavior; positive regulation of calcium-mediated signaling; positive regulation of interleukin-1 beta secretion; chemotaxis; protein amino acid phosphorylation; regulation of cell shape; negative regulation of bone mineralization; monocyte chemotaxis; positive chemotaxis; cell-cell signaling; calcium ion transport; positive regulation of neuron apoptosis; protein kinase B signaling cascade; lipopolysaccharide-mediated signaling pathway; inflammatory response; lymphocyte chemotaxis; neutrophil chemotaxis; calcium-mediated signaling; MAPKKK cascade; cytoskeleton organization and biogenesis; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; positive regulation of tumor necrosis factor production; macrophage chemotaxis; cellular calcium ion homeostasis; osteoblast differentiation; positive regulation of protein kinase B signaling cascade; cell activation; eosinophil chemotaxis; eosinophil degranulation; regulation of sensory perception of pain; positive regulation of calcium ion transport; astrocyte cell migration; positive regulation of cell migration; positive regulation of inflammatory response

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To

Research Articles on MIP 1a

1. MIP-1alpha levels in Jurkat cells appeared to be an important factor for its transendothelial migration

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MIP 1a recombinant protein

Reference Product	PubMed Publications
CCL4 recombinant protein	>1620 publications with MIP 1a and CCL4
CCR5 recombinant protein	>507 publications with MIP 1a and CCR5
CCR1 recombinant protein	>280 publications with MIP 1a and CCR1
CCR2 recombinant protein	>137 publications with MIP 1a and CCR2
CCR3 recombinant protein	>68 publications with MIP 1a and CCR3
CCR4 recombinant protein	>46 publications with MIP 1a and CCR4
IL18 recombinant protein	>20 publications with MIP 1a and IL18
IL1B recombinant protein	>15 publications with MIP 1a and IL1B
IDE recombinant protein	>5 publications with MIP 1a and IDE
CXCR5 recombinant protein	>4 publications with MIP 1a and CXCR5

Pathways associated with MIP 1a recombinant protein

Products by Pathway	Pathway Diagram
Chagas Disease (American Trypanosomiasis) Pathway antibodies	Chagas Disease (American Trypanosomiasis) Pathway Diagram
Chagas Disease (American Trypanosomiasis) Pathway antibodies	Chagas Disease (American Trypanosomiasis) Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram

Diseases associated with MIP 1a recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>893 publications with MIP 1a and Inflammation
Necrosis Antibodies	>506 publications with MIP 1a and Necrosis
Disease Models, Animal Antibodies	>314 publications with MIP 1a and Disease Models, Animal
Lung Diseases Antibodies	>238 publications with MIP 1a and Lung Diseases
HIV Infections Antibodies	>188 publications with MIP 1a and HIV Infections
Cardiovascular Diseases Antibodies	>173 publications with MIP 1a and Cardiovascular Diseases
Hypersensitivity Antibodies	>105 publications with MIP 1a and Hypersensitivity
Liver Diseases Antibodies	>95 publications with MIP 1a and Liver Diseases
Fibrosis Antibodies	>79 publications with MIP 1a and Fibrosis
Pneumonia Antibodies	>72 publications with MIP 1a and Pneumonia

Organs/Tissues associated with MIP 1a recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1553 publications with MIP 1a and Blood
Lung Antibodies	>328 publications with MIP 1a and Lung
Brain Antibodies	>257 publications with MIP 1a and Brain
Liver Antibodies	>216 publications with MIP 1a and Liver
Kidney Antibodies	>85 publications with MIP 1a and Kidney
Heart Antibodies	>79 publications with MIP 1a and Heart
Intestine Antibodies	>56 publications with MIP 1a and Intestine
Eye Antibodies	>51 publications with MIP 1a and Eye
Uterus Antibodies	>19 publications with MIP 1a and Uterus
Pancreas Antibodies	>18 publications with MIP 1a and Pancreas