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E3 Ubiquitin-Protein Ligase NHLRC1 (NHLRC1) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1420923

MBS1420923 is a recombinant protein targeting Nhlrc1. Also known as Recombinant Mouse E3 ubiquitin-protein ligase NHLRC1 (Nhlrc1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1140 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
E3 ubiquitin-protein ligase NHLRC1 (Nhlrc1), Recombinant Protein
Full Product Name
Recombinant Mouse E3 ubiquitin-protein ligase NHLRC1 (Nhlrc1)
Product Gene Name
Nhlrc1 recombinant protein
Product Synonym Gene Name
Nhlrc1
Sequence
MGEEATAVAA AGVRPELVRE AEVSLLECKV CFERFGHWQQ RRPRNLPCGH VVCLACVAAL AHPRTLGLEC PFCRRACRAC DTSDCLPVLH LLELLGSTLH ASPAALSAAP FAPGTLTCYH AFGGWGTLVN PTGLALCPKT GRVVVVHDGK RRVKIFDSGG GGAHQFGEKG DAAHDVKYPL DVAVTNDCHV VVTDAGDCSL KVFDFFGQIK LVVGKQFSLP WGVEITPHNG VLVTDAEAGT LHLLEADFPE GVLRRIERLQ AHLCSPRGLA VSWLTGAIAV LEHPCAFGRT GCNNTRVKVF NSTMQLIGQV DSFGLNLLFP SKVTASAVTF DHQGNVIVAD TSGPAIVCLG KPEEFPALKP IITHGLSRPV ALAFTKENSL LVLDTASHSI KVFKVMEGNG G
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
42,690 Da
Sequence Positions
1-401, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q8BR37
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Nhlrc1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Nhlrc1. It may not necessarily be applicable to this product.

NCBI GI #
30425030
NCBI GeneID
105193
NCBI Accession #
NP_780549.1
UniProt Primary Accession #
Q8BR37
UniProt Related Accession #
Q8BR37
GenBank Nucleotide #
NM_175340.4
NCBI Official Full Name
E3 ubiquitin-protein ligase NHLRC1
NCBI Official Synonym Full Names
NHL repeat containing 1
NCBI Official Symbol
Nhlrc1
NCBI Official Synonym Symbols
EPM2B; AI505271; B230309E09Rik
UniProt Protein Name
E3 ubiquitin-protein ligase NHLRC1
UniProt Synonym Protein Names
Malin; NHL repeat-containing protein 1; RING-type E3 ubiquitin transferase NHLRC1Curated
Protein Family
E3 ubiquitin-protein ligase
UniProt Gene Name
Nhlrc1
UniProt Synonym Gene Names
Epm2b
NCBI Protein Information
E3 ubiquitin-protein ligase NHLRC1

UniProt Comments for Nhlrc1

E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.
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Research Articles on Nhlrc1

1. that laforin and malin are novel regulators of mitochondrial quality control pathway and that the mitochondrial dysfunction resulting from the increased Drp1 levels could underlie neuropathology in Lafora disease

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Nhlrc1 recombinant protein

 Products by Pathway  Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram

Diseases associated with Nhlrc1 recombinant protein

 Disease Name  Pubmed Publications
 Lafora Disease Antibodies  >62 publications with Nhlrc1 and Lafora Disease
 Seizures Antibodies  >18 publications with Nhlrc1 and Seizures
 Brain Death Antibodies  >6 publications with Nhlrc1 and Brain Death
 Syndrome Antibodies  >2 publications with Nhlrc1 and Syndrome
 Neoplasms Antibodies  >1 publications with Nhlrc1 and Neoplasms
 Neuroectodermal Tumors Antibodies  >1 publications with Nhlrc1 and Neuroectodermal Tumors
 Eye Neoplasms Antibodies  >1 publications with Nhlrc1 and Eye Neoplasms

Organs/Tissues associated with Nhlrc1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >23 publications with Nhlrc1 and Brain
 Skin Antibodies  >13 publications with Nhlrc1 and Skin
 Muscle Antibodies  >5 publications with Nhlrc1 and Muscle
 Liver Antibodies  >4 publications with Nhlrc1 and Liver
 Spinal Cord Antibodies  >1 publications with Nhlrc1 and Spinal Cord
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