Human ARTN Active Protein – Cat# MBS142183

Artemin (ARTN) Human Active Protein

Name: ARTN Active Protein; Artemin; Human; MyBioSource
Brand: MyBioSource
SKU: MBS142183
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS142183

Description: Artemin Human Recombinant produced in E Coli is a disulfide-linked homodimer, non-glycosylated, polypeptide chain containing 2 x 113 amino acids and having a total molecular mass of 24205 Dalton. Artemin is purified by proprietary chromatographic… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Artemin (ARTN), Active Protein

Full Product Name

Recombinant Human Artemin

Product Gene Name

ARTN active protein

Product Synonym Names

Artemin Human; Artemin Human Recombinant; ART; ARTN; EVN; NBN; Artemin

Sequence

AGGPGSRARA AGARGCRLRS QLVPVRALGL GHRSDELVRF RFCSGSCRRA RSPHDLSLAS LLGAGALRPP PGSRPVSQPC CRPTRYEAVS FMDVNSTWRT VDRLSATACG CLG

Host

E Coli

Form/Format

Artemin was lyophilized after extensive dialysis against 10mM sodium citrate pH-4.5 and 150mM sodium chloride.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Preparation and Storage

Lyophilized Artemin although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Artemin Human Recombinant should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Molecular Weight

23,616 Da

OMIM

603886

3D Structure

ModBase 3D Structure for O95441

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility

It is recommended to reconstitute the lyophilized Artemin in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Biological Activity

The Biological activity is calculated by its ability to promote survival and neurite outgrowth and dorsal root ganglion neurons.

Product Categories/Family for ARTN active protein

Cytokines and Growth Factors; Neurotrophins

Other Notes

Small volumes of ARTN active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ARTN purchase

MBS142183 is an active protein targeting ARTN. Also known as Recombinant Human Artemin. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for ARTN. It may not necessarily be applicable to this product.

NCBI GI #

209977029

NCBI GeneID

9048

NCBI Accession #

NP_001129687.1

UniProt Primary Accession #

O95441

UniProt Secondary Accession #

O95441; O96030; Q6P6A3; D3DPY1; D3DPY3

UniProt Related Accession #

Q5T4W7

GenBank Nucleotide #

NM_001136215.1

NCBI Official Full Name

artemin isoform 3

NCBI Official Synonym Full Names

artemin

NCBI Official Symbol

ARTN

NCBI Official Synonym Symbols

EVN; NBN; ENOVIN

UniProt Protein Name

Artemin

UniProt Synonym Protein Names

Enovin; Neublastin

Protein Family

Artemin

UniProt Gene Name

ARTN

UniProt Synonym Gene Names

EVN

UniProt Entry Name

ARTN_HUMAN

NCBI Protein Information

artemin; neublastin; neurotrophic factor

NCBI Summary for ARTN

The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

UniProt Comments for ARTN

artemin: Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Belongs to the TGF-beta family. GDNF subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p34.1

Cellular Component: extracellular space

Molecular Function: growth factor activity; receptor binding

Biological Process: axon guidance; neuroblast proliferation; signal transduction; induction of positive chemotaxis; peripheral nervous system development

Research Articles on ARTN

1. conclude that ARTN is one mediator of acquired resistance to trastuzumab in HER2-positive mammary carcinoma cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ARTN active protein

Reference Product	PubMed Publications
GDNF active protein	>80 publications with ARTN and GDNF
NRTN active protein	>22 publications with ARTN and NRTN
GFRA3 active protein	>20 publications with ARTN and GFRA3
PSPN active protein	>9 publications with ARTN and PSPN
GFRA1 active protein	>8 publications with ARTN and GFRA1
TRIM27 active protein	>1 publications with ARTN and TRIM27
RAC1 active protein	>1 publications with ARTN and RAC1
NCAM1 active protein	>1 publications with ARTN and NCAM1

Pathways associated with ARTN active protein

Products by Pathway	Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
NCAM Signaling For Neurite Out-growth Pathway antibodies	NCAM Signaling For Neurite Out-growth Pathway Diagram
NCAM1 Interactions Pathway antibodies	NCAM1 Interactions Pathway Diagram

Diseases associated with ARTN active protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>27 publications with ARTN and Nervous System Diseases
Pain Antibodies	>24 publications with ARTN and Pain
Carcinoma Antibodies	>16 publications with ARTN and Carcinoma
Neoplasm Invasiveness Antibodies	>10 publications with ARTN and Neoplasm Invasiveness
Breast Neoplasms Antibodies	>8 publications with ARTN and Breast Neoplasms
Inflammation Antibodies	>4 publications with ARTN and Inflammation
Lung Diseases Antibodies	>3 publications with ARTN and Lung Diseases
Hypertrophy Antibodies	>3 publications with ARTN and Hypertrophy
Lung Neoplasms Antibodies	>3 publications with ARTN and Lung Neoplasms
Carcinoma, Squamous Cell Antibodies	>2 publications with ARTN and Carcinoma, Squamous Cell

Organs/Tissues associated with ARTN active protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>23 publications with ARTN and Brain
Pancreas Antibodies	>4 publications with ARTN and Pancreas
Kidney Antibodies	>4 publications with ARTN and Kidney
Intestine Antibodies	>4 publications with ARTN and Intestine
Lung Antibodies	>4 publications with ARTN and Lung
Esophagus Antibodies	>1 publications with ARTN and Esophagus