Interleukin-2 (mIL 2) Mouse Active Protein

IL2: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells. A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. Belongs to the IL-2 family.

Protein type: Oncoprotein; Secreted; Secreted, signal peptide; Cytokine

Cellular Component: extracellular space; cell; extracellular region; cytosol

Molecular Function: growth factor activity; interleukin-2 receptor binding; cytokine activity; glycosphingolipid binding; carbohydrate binding; kappa-type opioid receptor binding

Biological Process: positive regulation of interleukin-17 production; positive regulation of isotype switching to IgG isotypes; regulation of T cell homeostatic proliferation; positive regulation of regulatory T cell differentiation; negative regulation of heart contraction; immune system process; positive regulation of immunoglobulin secretion; positive regulation of activated T cell proliferation; negative regulation of lymphocyte proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; positive regulation of interferon-gamma production; positive regulation of T cell differentiation; negative regulation of protein amino acid phosphorylation; positive regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of inflammatory response; protein kinase C activation; positive regulation of B cell proliferation; immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of T cell proliferation; positive regulation of protein amino acid phosphorylation; negative regulation of B cell apoptosis