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Myotubularin-Related Protein 2 (MTMR2) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1422990

This gene is a member of the myotubularin family. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B,… More details

$1455 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Myotubularin-related protein 2 (MTMR2), Recombinant Protein
Full Product Name
Recombinant Human Myotubularin-related protein 2 (MTMR2)
Product Gene Name
MTMR2 recombinant protein
Product Synonym Gene Name
MTMR2
Sequence
MEKSSSCESL GSQPAAARPP SVDSLSSAST SHSENSVHTK SASVVSSDSI STSADNFSPD LRVLRESNKL AEMEEPPLLP GENIKDMAKD VTYICPFTGA VRGTLTVTNY RLYFKSMERD PPFVLDASLG VINRVEKIGG ASSRGENSYG LETVCKDIRN LRFAHKPEGR TRRSIFENLM KYAFPVSNNL PLFAFEYKEV FPENGWKLYD PLLEYRRQGI PNESWRITKI NERYELCDTY PALLVVPANI PDEELKRVAS FRSRGRIPVL SWIHPESQAT ITRCSQPMVG VSGKRSKEDE KYLQAIMDSN AQSHKIFIFD ARPSVNAVAN KAKGGGYESE DAYQNAELVF LDIHNIHVMR ESLRKLKEIV YPNIEETHWL SNLESTHWLE HIKLILAGAL RIADKVESGK TSVVVHCSDG WDRTAQLTSL AMLMLDGYYR TIRGFEVLVE KEWLSFGHRF QLRVGHGDKN HADADRSPVF LQFIDCVWQM TRQFPTAFEF NEYFLITILD HLYSCLFGTF LCNSEQQRGK ENLPKRTVSL WSYINSQLED FTNPLYGSYS NHVLYPVASM RHLELWVGYY IRWNPRMKPQ EPIHNRYKEL LAKRAELQKK VEELQREISN RSTSSSERAS SPAQCVTPVQ TVV
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
65,959 Da
Sequence Positions
1-643, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
601382
3D Structure
ModBase 3D Structure for Q13614
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of MTMR2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MTMR2 purchase

MBS1422990 is a recombinant protein targeting MTMR2. Also known as Recombinant Human Myotubularin-related protein 2 (MTMR2). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for MTMR2. It may not necessarily be applicable to this product.

NCBI GI #
343790884
NCBI GeneID
8898
NCBI Accession #
NP_001230500.1
UniProt Primary Accession #
Q13614
UniProt Secondary Accession #
Q9UPS9; A6NN98
UniProt Related Accession #
Q13614
GenBank Nucleotide #
NM_001243571.1
NCBI Official Full Name
myotubularin-related protein 2 isoform 2
NCBI Official Synonym Full Names
myotubularin related protein 2
NCBI Official Symbol
MTMR2
NCBI Official Synonym Symbols
CMT4B; CMT4B1
UniProt Protein Name
Myotubularin-related protein 2
UniProt Synonym Protein Names
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase (EC:3.1.3.95
Protein Family
Myotubularin-related protein
UniProt Gene Name
MTMR2
UniProt Synonym Gene Names
KIAA1073
NCBI Protein Information
myotubularin-related protein 2

NCBI Summary for MTMR2

This gene is a member of the myotubularin family of phosphoinositide lipid phosphatases. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
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UniProt Comments for MTMR2

Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate.

Research Articles on MTMR2

1. Expression of several MTMR2 isoforms ameliorates the myopathic phenotype owing to MTM1 loss, with increased muscle force, reduced myofiber atrophy, and reduction of the intracellular disorganization hallmarks associated with myotubular myopathy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MTMR2 recombinant protein

 Reference Product  PubMed Publications
 FIG4 recombinant protein  >8 publications with MTMR2 and FIG4
 NEFL recombinant protein  >6 publications with MTMR2 and NEFL
 PIKFYVE recombinant protein  >3 publications with MTMR2 and PIKFYVE
 VAC14 recombinant protein  >1 publications with MTMR2 and VAC14

Pathways associated with MTMR2 recombinant protein

 Products by Pathway  Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PI Metabolism Pathway antibodies  PI Metabolism Pathway Diagram
 Phospholipid Metabolism Pathway antibodies  Phospholipid Metabolism Pathway Diagram
 Synthesis Of PIPs At The Early Endosome Membrane Pathway antibodies  Synthesis Of PIPs At The Early Endosome Membrane Pathway Diagram
 Synthesis Of PIPs At The Late Endosome Membrane Pathway antibodies  Synthesis Of PIPs At The Late Endosome Membrane Pathway Diagram

Diseases associated with MTMR2 recombinant protein

 Disease Name  Pubmed Publications
 Charcot-Marie-Tooth disease, Type 4B1 Antibodies  >4 publications with MTMR2 and Charcot-Marie-Tooth disease, Type 4B1
 Atrophy Antibodies  >3 publications with MTMR2 and Atrophy
 Abnormalities, Multiple Antibodies  >2 publications with MTMR2 and Abnormalities, Multiple
 Infertility, Male Antibodies  >1 publications with MTMR2 and Infertility, Male
 Necrosis Antibodies  >1 publications with MTMR2 and Necrosis

Organs/Tissues associated with MTMR2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >38 publications with MTMR2 and Nerve
 Muscle Antibodies  >12 publications with MTMR2 and Muscle
 Brain Antibodies  >10 publications with MTMR2 and Brain
 Testis Antibodies  >4 publications with MTMR2 and Testis
 Embryonic Tissue Antibodies  >3 publications with MTMR2 and Embryonic Tissue
 Pancreas Antibodies  >1 publications with MTMR2 and Pancreas
 Liver Antibodies  >1 publications with MTMR2 and Liver
 Vascular Antibodies  >1 publications with MTMR2 and Vascular
 Kidney Antibodies  >1 publications with MTMR2 and Kidney
 Eye Antibodies  >1 publications with MTMR2 and Eye
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