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Endoglin (ENG) Mouse Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS142300

Description: CD105 Mouse Recombinant extracellular domain produced in baculovirus is a homodimeric, glycosylated, Polypeptide containing 581 amino acids and having a molecular mass of 61 kDa but as a result of glycosylation, migrates at 75-85 kDa under… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Endoglin (Eng), Active Protein
Full Product Name
Recombinant Mouse Endoglin
Product Gene Name
Eng active protein
Product Synonym Names
Endoglin Mouse; Endoglin Mouse Recombinant; CD105; ENG; END; ORW; HHT1; ORW1; FLJ41744; Cell surface MJ7/18 antigen; Endoglin; mEndoglin
Sequence
MDRGVLPLPI TLLFVIYSFV PTTGLAERVG CDLQPVDPTR GEVTFTTSQV SEGCVAQAAN AVREVHVLFL DFPGMLSHLE LTLQASKQNG TETQEVFLVL VSNKNVFVKF QAPEIPLHLA YDSSLVIFQG QPRVNITVLP SLTSRKQILD WAATKGAITS IAALDDPQSI VLQLGQDPKA PFLCLPEAHK DMGATLEWQP RAQTPVQSCR LEGVSGHKEA YILRILPGSE AGPRTVTVMM ELSCTSGDAI LILHGPPYVS WFIDINHSMQ ILTTGEYSVK IFPGSKVKGV ELPDTPQGLI AEARKLNASI VTSFVELPLV SNVSLRASSC GGVFQTTPAP VVTTPPKDTC SPVLLMSLIQ PKCGNQVMTL ALNKKHVQTL QCTITGLTFW DSSCQAEDTD DHLVLSSAYS SCGMKVTAHV VSNEVIISFP SGSPPLRKKV QCIDMDSLSF QLGLYLSPHF LQASNTIELG QQAFVQVSVS PLTSEVTVQL DSCHLDLGPE GDMVELIQSR TAKGSCVTLL SPSPEGDPRF SFLLRVYMVP TPTAGTLSCN LALRPSTLSQ EVYKTVSMRL NIVSPDLS
Host
Insect Cells
Form/Format
Endoglin was lyophilized from a concentrated (1mg/ml) sterile solution containing no additives.
Sterile Filtered White lyophilized (freeze-dried) powder.
Purity/Purification
Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Preparation and Storage
Lyophilized Endoglin although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CD105 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Molecular Weight
70,021 Da
3D Structure
ModBase 3D Structure for Q63961
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility
It is recommended to reconstitute the lyophilized CD-105 in sterile PBS not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Biological Activity
Measured by its ability to bind with rhTGF-beta RII/Fc in a functional ELISA. Optimal dilutions should be determined by each laboratory for each application.

Product Categories/Family for Eng active protein

Cytokines and Growth Factors; Cytokines; Endoglin

Other Notes

Small volumes of Eng active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Eng purchase

MBS142300 is an active protein targeting Eng. Also known as Recombinant Mouse Endoglin. Host: Insect Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for Eng. It may not necessarily be applicable to this product.

NCBI GI #
226437647
NCBI GeneID
13805
NCBI Accession #
NP_031958.2
UniProt Primary Accession #
Q63961
UniProt Secondary Accession #
Q61520; Q8K100
UniProt Related Accession #
Q63961
GenBank Nucleotide #
NM_007932.2
NCBI Official Full Name
endoglin isoform 1
NCBI Official Synonym Full Names
endoglin
NCBI Official Symbol
Eng
NCBI Official Synonym Symbols
Endo; CD105; AI528660; AI662476; S-endoglin
UniProt Protein Name
Endoglin
UniProt Synonym Protein Names
Cell surface MJ7/18 antigen; CD_antigen: CD105
Protein Family
Endoglin
UniProt Gene Name
Eng
UniProt Synonym Gene Names
Edg
UniProt Entry Name
EGLN_MOUSE
NCBI Protein Information
endoglin; cell surface MJ7/18 antigen; transmembrane glycoprotein

UniProt Comments for Eng

ENG: Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It is able to bind TGF-beta 1, and 3 efficiently and TGF-beta 2 less efficiently. Interacts with TCTEX1D4. Interacts with ARRB2. Endoglin is restricted to endothelial cells in all tissues except bone marrow. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral; Motility/polarity/chemotaxis

Cellular Component: nucleoplasm; extracellular space; cell surface; focal adhesion; membrane; cytoplasm; integral to membrane; receptor complex; external side of plasma membrane

Molecular Function: transforming growth factor beta receptor activity; protein binding; glycosaminoglycan binding; protein homodimerization activity; transforming growth factor beta binding; galactose binding; punt binding; transforming growth factor beta receptor, cytoplasmic mediator activity

Biological Process: wound healing; heart development; positive regulation of collagen biosynthetic process; cell motility involved in cell locomotion; positive regulation of systemic arterial blood pressure; negative regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; smooth muscle development; extracellular matrix disassembly; regulation of transforming growth factor beta receptor signaling pathway; central nervous system vasculogenesis; venous blood vessel morphogenesis; regulation of transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein serine/threonine kinase signaling pathway; negative regulation of protein amino acid autophosphorylation; heart looping; angiogenesis; vasculogenesis; cell adhesion; negative regulation of cell migration; positive regulation of BMP signaling pathway; cell migration; negative regulation of nitric-oxide synthase activity; patterning of blood vessels; positive regulation of angiogenesis; negative regulation of endothelial cell proliferation; response to hypoxia; artery morphogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation
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Research Articles on Eng

1. Endoglin modulates intestinal angiogenic and inflammatory responses in colitis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Eng active protein

 Products by Pathway  Pathway Diagram
 TGF Beta Signaling Pathway antibodies  TGF Beta Signaling Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
 XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway antibodies  XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway Diagram

Diseases associated with Eng active protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6402 publications with Eng and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >5581 publications with Eng and Cardiovascular Diseases
 Heart Diseases Antibodies  >2916 publications with Eng and Heart Diseases
 Breast Neoplasms Antibodies  >756 publications with Eng and Breast Neoplasms
 Disease Models, Animal Antibodies  >743 publications with Eng and Disease Models, Animal
 Inflammation Antibodies  >646 publications with Eng and Inflammation
 Hypertension Antibodies  >612 publications with Eng and Hypertension
 Liver Diseases Antibodies  >471 publications with Eng and Liver Diseases
 Atherosclerosis Antibodies  >443 publications with Eng and Atherosclerosis
 Necrosis Antibodies  >412 publications with Eng and Necrosis

Organs/Tissues associated with Eng active protein

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >7981 publications with Eng and Bone
 Brain Antibodies  >7862 publications with Eng and Brain
 Heart Antibodies  >7827 publications with Eng and Heart
 Muscle Antibodies  >6934 publications with Eng and Muscle
 Skin Antibodies  >2866 publications with Eng and Skin
 Connective Tissue Antibodies  >2415 publications with Eng and Connective Tissue
 Eye Antibodies  >2028 publications with Eng and Eye
 Lung Antibodies  >1920 publications with Eng and Lung
 Liver Antibodies  >1506 publications with Eng and Liver
 Bone Marrow Antibodies  >1328 publications with Eng and Bone Marrow
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