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Carbamoyl-Phosphate Synthase [Ammonia], Mitochondrial (CPS1) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1423195

This protein is an enzyme that catalyzes the first committed step of the hepatic urea cycle, which is important in the removal of excess urea from cells. There are two isozymes of this enzyme, and the encoded protein is the mitochondrial form. Three… More details

$455 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Carbamoyl-phosphate synthase [ammonia], mitochondrial (Cps1), Recombinant Protein
Full Product Name
Recombinant Mouse Carbamoyl-phosphate synthase [ammonia], mitochondrial (Cps1) , partial
Product Gene Name
Cps1 recombinant protein
Product Synonym Gene Name
Cps1
Sequence
SDKLNEINEK IAPSFAVESM EDALKAADTI GYPVMIRSAY ALGGLGSGIC PNKETLIDLG TKAFAMTNQI LVERSVTGWK EIEYEVVRDA DDNCVTVCNM ENVDAMGVHT GDSVVVAPAQ TLSNAEFQML RRTSVNVVRH LGIVGECNIQ FALHPTSMEY CIIEVNARLS RSSALASKAT GYPLAFIAAK IAL
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
164,618 Da
Sequence Positions
551-743aa; Partial
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q8C196
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Cps1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cps1 purchase

MBS1423195 is a recombinant protein targeting Cps1. Also known as Recombinant Mouse Carbamoyl-phosphate synthase [ammonia], mitochondrial (Cps1) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Cps1. It may not necessarily be applicable to this product.

NCBI GI #
124248512
NCBI GeneID
227231
NCBI Accession #
NP_001074278.1
UniProt Primary Accession #
Q8C196
UniProt Secondary Accession #
Q6NX75; A0JNU4
UniProt Related Accession #
Q8C196
GenBank Nucleotide #
NM_001080809.2
NCBI Official Full Name
carbamoyl-phosphate synthase
NCBI Official Synonym Full Names
carbamoyl-phosphate synthetase 1
NCBI Official Symbol
Cps1
NCBI Official Synonym Symbols
CPS; D1Ucla3; 4732433M03Rik
UniProt Protein Name
Carbamoyl-phosphate synthase [ammonia], mitochondrial
UniProt Synonym Protein Names
Carbamoyl-phosphate synthetase I; CPSase I
Protein Family
Carboxypeptidase
UniProt Gene Name
Cps1
UniProt Synonym Gene Names
CPSase I
NCBI Protein Information
carbamoyl-phosphate synthase [ammonia], mitochondrial

NCBI Summary for Cps1

This gene encodes a protein localized to the inner mitochondrial matrix. The encoded protein plays a role in the detoxification of ammonia by catalyzing the first step in the urea cycle in which carbomyl-phosphate is synthesized from ammonia and bicarbonate. Carbamoyl-phosphate is subsequently converted to urea that is excreted by the kidneys. Deficiency of the encoded enzyme leads to an accumulation of ammonia in the blood. High levels of ammonia are toxic to the central nervous system and result in neurological disorders. [provided by RefSeq, Oct 2013]
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UniProt Comments for Cps1

Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.

Research Articles on Cps1

1. these data suggest that AhR activation promotes CPS1 recruitment to DNA enhancer sites in the genome, resulting in a specific enzyme-independent post-translational modification of the linker histone H1 protein (H1K34hcit), pivotal in altering local chromatin structure and transcriptional activation.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Cps1 recombinant protein

 Products by Pathway  Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Urea Cycle Pathway antibodies  Urea Cycle Pathway Diagram
 Urea Cycle Pathway antibodies  Urea Cycle Pathway Diagram
 Urea Cycle Pathway antibodies  Urea Cycle Pathway Diagram
 Urea Cycle And Metabolism Of Amino Groups Pathway antibodies  Urea Cycle And Metabolism Of Amino Groups Pathway Diagram

Diseases associated with Cps1 recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >18 publications with Cps1 and Nervous System Diseases
 Brain Diseases Antibodies  >18 publications with Cps1 and Brain Diseases
 Hyperammonemia Antibodies  >16 publications with Cps1 and Hyperammonemia
 Carbamoyl-Phosphate Synthase I Deficiency Disease Antibodies  >13 publications with Cps1 and Carbamoyl-Phosphate Synthase I Deficiency Disease
 Neoplasms Antibodies  >11 publications with Cps1 and Neoplasms
 Liver Diseases Antibodies  >9 publications with Cps1 and Liver Diseases
 Liver Neoplasms Antibodies  >7 publications with Cps1 and Liver Neoplasms
 Carcinoma Antibodies  >6 publications with Cps1 and Carcinoma
 Adenocarcinoma Antibodies  >4 publications with Cps1 and Adenocarcinoma
 Kidney Diseases Antibodies  >4 publications with Cps1 and Kidney Diseases

Organs/Tissues associated with Cps1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >26 publications with Cps1 and Liver
 Intestine Antibodies  >5 publications with Cps1 and Intestine
 Lung Antibodies  >3 publications with Cps1 and Lung
 Skin Antibodies  >2 publications with Cps1 and Skin
 Embryonic Tissue Antibodies  >1 publications with Cps1 and Embryonic Tissue
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