Myostatin (MSTN) Human Recombinant Protein

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth. [provided by RefSeq, Jul 2008]

MSTN: Acts specifically as a negative regulator of skeletal muscle growth. Defects in MSTN are the cause of muscle hypertrophy (MSLHP). MSLHP is a condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2q32.2

Cellular Component: extracellular space; cytoplasm

Molecular Function: heparin binding; identical protein binding; protein binding; growth factor activity; cytokine activity; transforming growth factor beta receptor binding; receptor binding

Biological Process: response to gravity; muscle development; response to muscle activity; positive regulation of transcription, DNA-dependent; skeletal muscle regeneration; response to testosterone stimulus; ovulation cycle process; regulation of apoptosis; skeletal muscle atrophy; response to ethanol; negative regulation of muscle hypertrophy; response to heat; response to estrogen stimulus; regulation of MAPKKK cascade; transforming growth factor beta receptor signaling pathway; negative regulation of skeletal muscle growth; response to electrical stimulus; cell development

Disease: Muscle Hypertrophy