Human MMP 8 Active Protein – Cat# MBS142442

Matrix Metalloproteinase-8 (MMP 8) Human Active Protein

Name: MMP 8 Active Protein; Matrix Metalloproteinase-8; Human; MyBioSource
Brand: MyBioSource
SKU: MBS142442
Price: 310 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS142442

Description: Matrix Metalloproteinase-8 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain having a molecular mass of 75 kDa.The MMP-8 is purified by proprietary chromatographic techniques. More details

$310 / 1 Unit +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Matrix Metalloproteinase-8 (MMP 8), Active Protein

Full Product Name

Recombinant Human Matrix Metalloproteinase-8

Product Gene Name

MMP 8 active protein

Product Synonym Names

MMP 8 Human; Neutrophil collagenase; EC 3.4.24.34; Matrix metalloproteinase-8; MMP-8; PMNL collagenase; PMNL-CL; HNC; CLG1

Form/Format

The MMP-8 protein solution (100 units/ml) in 0.05M Tris-HCl buffer, pH 7.6, 0.2M NaCl, 5mM CaCl₂, 0.0025% NaN₃ and 0.1% BSA

Purity/Purification

Greater than 90% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks.
Store, frozen at -20 degree C for longer periods of time.
Avoid multiple freeze-thaw cycles.

OMIM

120355

3D Structure

ModBase 3D Structure for P22894

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Source

E.coli

Physical Appearance

Sterile Filtered clear solution

Biological Activity

100 units/ml after activation with APMA by solution assay method.One unit of collagenolytic activity is defined as the cleavage of 1 ug of collagen per minute by the solution method.

Product Categories/Family for MMP 8 active protein

Enzymes; Matrix Metalloproteinase

Application Notes for MMP 8 active protein

Used as a standard for analyzing mammalian collagenase activity.

Other Notes

Small volumes of MMP 8 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MMP 8 purchase

MBS142442 is an active protein targeting MMP 8. Also known as Recombinant Human Matrix Metalloproteinase-8.

Additional Details

NCBI/Uniprot data below describe general gene information for MMP 8. It may not necessarily be applicable to this product.

NCBI GI #

4505221

NCBI GeneID

4317

NCBI Accession #

NP_002415.1

UniProt Primary Accession #

P22894

UniProt Secondary Accession #

Q45F99

UniProt Related Accession #

P22894

GenBank Nucleotide #

NM_002424.2

NCBI Official Full Name

neutrophil collagenase isoform 1 preproprotein

NCBI Official Synonym Full Names

matrix metallopeptidase 8

NCBI Official Symbol

MMP8

NCBI Official Synonym Symbols

HNC; CLG1; MMP-8; PMNL-CL

UniProt Protein Name

Neutrophil collagenase

UniProt Synonym Protein Names

Matrix metalloproteinase-8; MMP-8; PMNL collagenase; PMNL-CL

Protein Family

Neutrophil collagenase

UniProt Gene Name

MMP8

UniProt Synonym Gene Names

CLG1; MMP-8; PMNL-CL

UniProt Entry Name

MMP8_HUMAN

NCBI Protein Information

neutrophil collagenase; PMN leukocyte collagenase; PMNL collagenase; collagenase 2; matrix metallopeptidase 8 (neutrophil collagenase); matrix metalloproteinase 8 (neutrophil collagenase); matrix metalloproteinase-8

NCBI Summary for MMP 8

This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

UniProt Comments for MMP 8

MMP8: Can degrade fibrillar type I, II, and III collagens. Belongs to the peptidase M10A family.

Protein type: Secreted; EC 3.4.24.34; Protease; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q22.3

Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region

Molecular Function: zinc ion binding; serine-type endopeptidase activity; metalloendopeptidase activity; calcium ion binding

Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; proteolysis

Research Articles on MMP 8

1. Plasma and BALF MMP-8 levels are unlikely to serve as a prognostic biomarker for IPF patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MMP 8 active protein

Reference Product	PubMed Publications
TIMP1 active protein	>27 publications with MMP 8 and TIMP1
TIMP2 active protein	>11 publications with MMP 8 and TIMP2
CCL2 active protein	>6 publications with MMP 8 and CCL2
PTGS2 active protein	>2 publications with MMP 8 and PTGS2
EFNB1 active protein	>1 publications with MMP 8 and EFNB1
ELANE active protein	>1 publications with MMP 8 and ELANE

Pathways associated with MMP 8 active protein

Products by Pathway	Pathway Diagram
Activation Of Matrix Metalloproteinases Pathway antibodies	Activation Of Matrix Metalloproteinases Pathway Diagram
Collagen Degradation Pathway antibodies	Collagen Degradation Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Matrix Metalloproteinases Pathway antibodies	Matrix Metalloproteinases Pathway Diagram

Diseases associated with MMP 8 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>76 publications with MMP 8 and Inflammation
Cardiovascular Diseases Antibodies	>35 publications with MMP 8 and Cardiovascular Diseases
Disease Models, Animal Antibodies	>26 publications with MMP 8 and Disease Models, Animal
Fibrosis Antibodies	>26 publications with MMP 8 and Fibrosis
Lung Diseases Antibodies	>17 publications with MMP 8 and Lung Diseases
Necrosis Antibodies	>16 publications with MMP 8 and Necrosis
Atherosclerosis Antibodies	>14 publications with MMP 8 and Atherosclerosis
Wounds and Injuries Antibodies	>14 publications with MMP 8 and Wounds and Injuries
Heart Diseases Antibodies	>12 publications with MMP 8 and Heart Diseases
Liver Diseases Antibodies	>10 publications with MMP 8 and Liver Diseases

Organs/Tissues associated with MMP 8 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>84 publications with MMP 8 and Blood
Connective Tissue Antibodies	>15 publications with MMP 8 and Connective Tissue
Skin Antibodies	>14 publications with MMP 8 and Skin
Liver Antibodies	>10 publications with MMP 8 and Liver
Bone Marrow Antibodies	>9 publications with MMP 8 and Bone Marrow