Human MAT2A Recombinant Protein – Cat# MBS142461

Methionine Adenosyltransferase II, Alpha (MAT2A) Human Recombinant Protein

Name: MAT2A Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS142461
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS142461

Description: MAT2A Human Recombinant fused with His tag (20 a.a.) at C-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 415 amino acids and having a molecular mass of 45.8 kDa.The MAT2A is purified by proprietary… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Methionine Adenosyltransferase II, Alpha (MAT2A), Recombinant Protein

Full Product Name

Recombinant Human Methionine Adenosyltransferase II, Alpha

Product Gene Name

MAT2A recombinant protein

Product Synonym Names

MAT2A Human; Methionine Adenosyltransferase II Alpha Human Recombinant; MATA2; MATII; SAMS2; MAT-2A; S-adenosylmethionine synthetase isoform type-2; AdoMet synthetase 2; Methionine adenosyltransferase 2; Methionine adenosyltransferase II; MAT2A; AMS2

Sequence

MGSSHHH HHH SSGLVPRGSH MNGQLNGFHE AFIEEGTFLF TSESVGEGHP DKICDQISDA VLDAHLQQDP DAKVACETVA KTGMILLAGE ITSRAAVDYQ KVVREAVKHI GYDDSSKGFD YKTCNVLVAL EQQSPDIAQG VHLDRNEEDI GAGDQGLMFG YATDETEECM PLTIVLAHKL NAKLAELRRN GTLPWLRPDS KTQVTVQYMQ DRGAVLPIRV HTIVISVQHD EEVCLDEMRD ALKEKVIKAV VPAKYLDEDT IYHLQPSGRF VIGGPQGDAG LTGRKIIVDT YGGWGAHGGG AFSGKDYTKV DRSAAYAARW VAKSLVKGGL CRRVLVQVSY AIGVSHPLSI SIFHYGTSQK SERELLEIVK KNFDLRPGVI VRDLDLKKPI YQRTAAYGHF GRDSFPWEVP KKLKY

Host

E Coli

Form/Format

The MAT2A solution (1mg/ml) contains 20mM Tris pH-8 & 10% glycerol.
Sterile Filtered colorless solution.

Purity/Purification

Greater than 95.0% as determined by SDS-PAGE.

Preparation and Storage

MAT2A although stable 4 degree C for 4 weeks, should be stored desiccated below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Molecular Weight

32,965 Da

OMIM

601468

3D Structure

ModBase 3D Structure for P31153

Product Categories/Family for MAT2A recombinant protein

Enzymes; Transferase

Other Notes

Small volumes of MAT2A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MAT2A purchase

MBS142461 is a recombinant protein targeting MAT2A. Also known as Recombinant Human Methionine Adenosyltransferase II, Alpha. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for MAT2A. It may not necessarily be applicable to this product.

NCBI GI #

5174529

NCBI GeneID

4144

NCBI Accession #

NP_005902.1

UniProt Primary Accession #

P31153

UniProt Secondary Accession #

Q53SP5; A8K511; B4DN45; D6W5L1

UniProt Related Accession #

P31153

GenBank Nucleotide #

NM_005911.5

NCBI Official Full Name

S-adenosylmethionine synthase isoform type-2

NCBI Official Synonym Full Names

methionine adenosyltransferase II, alpha

NCBI Official Symbol

MAT2A

NCBI Official Synonym Symbols

MATA2; MATII; SAMS2

UniProt Protein Name

S-adenosylmethionine synthase isoform type-2

UniProt Synonym Protein Names

Methionine adenosyltransferase 2; MAT 2; Methionine adenosyltransferase II; MAT-II

Protein Family

S-adenosylmethionine synthase

UniProt Gene Name

MAT2A

UniProt Synonym Gene Names

AMS2; MATA2; AdoMet synthase 2; MAT 2; MAT-II

UniProt Entry Name

METK2_HUMAN

NCBI Protein Information

S-adenosylmethionine synthase isoform type-2; MAT 2; MAT-II; adoMet synthase 2; adoMet synthetase 2; methionine adenosyltransferase 2

NCBI Summary for MAT2A

The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011]

UniProt Comments for MAT2A

MAT2A: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. Belongs to the AdoMet synthase family.

Protein type: Amino Acid Metabolism - cysteine and methionine; Other Amino Acids Metabolism - selenoamino acid; EC 2.5.1.6; Transferase

Chromosomal Location of Human Ortholog: 2p11.2

Cellular Component: methionine adenosyltransferase complex; cytosol

Molecular Function: protein binding; methionine adenosyltransferase activity; metal ion binding; ATP binding

Biological Process: methylation; xenobiotic metabolic process; S-adenosylmethionine biosynthetic process; one-carbon compound metabolic process

Research Articles on MAT2A

1. Results suggest that MAT2A is downregulated in cancer tissues of renal cell carcinomas patients and has function of tumor suppressor though repressing the expression of heme oxygenase-1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MAT2A recombinant protein

Reference Product	PubMed Publications
MAT2B recombinant protein	>11 publications with MAT2A and MAT2B
MYB recombinant protein	>6 publications with MAT2A and MYB
BHMT recombinant protein	>5 publications with MAT2A and BHMT
DNMT1 recombinant protein	>2 publications with MAT2A and DNMT1
MTR recombinant protein	>2 publications with MAT2A and MTR
TRDMT1 recombinant protein	>1 publications with MAT2A and TRDMT1
DNMT3B recombinant protein	>1 publications with MAT2A and DNMT3B
BHMT2 recombinant protein	>1 publications with MAT2A and BHMT2

Pathways associated with MAT2A recombinant protein

Products by Pathway	Pathway Diagram
Biological Oxidations Pathway antibodies	Biological Oxidations Pathway Diagram
Biosynthesis Of Amino Acids Pathway antibodies	Biosynthesis Of Amino Acids Pathway Diagram
Biosynthesis Of Amino Acids Pathway antibodies	Biosynthesis Of Amino Acids Pathway Diagram
C-MYB Transcription Factor Network Pathway antibodies	C-MYB Transcription Factor Network Pathway Diagram
Cysteine And Methionine Metabolism Pathway antibodies	Cysteine And Methionine Metabolism Pathway Diagram
Cysteine And Methionine Metabolism Pathway antibodies	Cysteine And Methionine Metabolism Pathway Diagram
Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway antibodies	Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway Diagram
Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway antibodies	Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway Diagram
Defective GGT1 Causes Glutathionuria (GLUTH) Pathway antibodies	Defective GGT1 Causes Glutathionuria (GLUTH) Pathway Diagram
Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway antibodies	Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway Diagram

Diseases associated with MAT2A recombinant protein

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>48 publications with MAT2A and Liver Diseases
Liver Neoplasms Antibodies	>33 publications with MAT2A and Liver Neoplasms
Carcinoma, Hepatocellular Antibodies	>31 publications with MAT2A and Carcinoma, Hepatocellular
Liver Cirrhosis Antibodies	>10 publications with MAT2A and Liver Cirrhosis
Disease Models, Animal Antibodies	>10 publications with MAT2A and Disease Models, Animal
Necrosis Antibodies	>8 publications with MAT2A and Necrosis
Nervous System Diseases Antibodies	>6 publications with MAT2A and Nervous System Diseases
Drug-Induced Liver Injury Antibodies	>5 publications with MAT2A and Drug-Induced Liver Injury
Neoplasms, Experimental Antibodies	>4 publications with MAT2A and Neoplasms, Experimental
Liver Cirrhosis, Experimental Antibodies	>4 publications with MAT2A and Liver Cirrhosis, Experimental

Organs/Tissues associated with MAT2A recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>75 publications with MAT2A and Liver
Blood Antibodies	>13 publications with MAT2A and Blood
Brain Antibodies	>10 publications with MAT2A and Brain
Kidney Antibodies	>5 publications with MAT2A and Kidney
Muscle Antibodies	>5 publications with MAT2A and Muscle
Heart Antibodies	>4 publications with MAT2A and Heart
Nerve Antibodies	>3 publications with MAT2A and Nerve
Spleen Antibodies	>3 publications with MAT2A and Spleen
Stomach Antibodies	>2 publications with MAT2A and Stomach
Lung Antibodies	>2 publications with MAT2A and Lung