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Secreted Phospholipase A2-IID (PLA2G2D) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS142467

Description: Secreted Phospholipase A2-IID Human Recombinant was produced with N-terminal His-Tag. PLA2G2D His-Tagged Fusion protein is 16.4 kDa containing 125 amino acid residues of the human secreted phospholipase A2-IID and 16 additional amino acid… More details

$250 / 0.002 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Secreted Phospholipase A2-IID (PLA2G2D), Recombinant Protein
Full Product Name
Recombinant Human Secreted Phospholipase A2-IID
Product Gene Name
PLA2G2D recombinant protein
Product Synonym Names
PLA2G2D Human; Secreted Phospholipase A2-IID Human Recombinant; Group IID secretory phospholipase A2; EC 3.1.1.4; Phosphatidylcholine 2-acylhydrolase GIID; GIID sPLA2; PLA2IID; sPLA(2)-IID; Secretory-type PLA; stroma-associated homolog; SPLASH; sPLA2S; PLA2G2D
Sequence
MRGSHHH HHHGMASHM< /u>GILNLNK MVKQVTGKMP ILSYWPYGCH CGLGGR GQPKDATDWC CQTHDCCYDH LKTQGCGIYK YYRYNFSQGN IHCSDKGSWC EQQLCACDKE VAFCLKRNLD TYQKRLRFYW RPHCRGQTPG C
Host
E Coli
Form/Format
Sterile filtered and lyophilized from 0.5 mg/ml in 0.05M Acetate buffer pH-4.
Sterile Filtered lyophilized (freeze-dried) powder.
Preparation and Storage
Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.
Molecular Weight
16,546 Da
OMIM
605630
3D Structure
ModBase 3D Structure for Q9UNK4
Solubility
Add 0.2 ml of 0.1M Acetate buffer pH-4 and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10 ug/ml. In higher concentrations the solubility of this antigen is limited.

Product Categories/Family for PLA2G2D recombinant protein

Enzymes; Secreted Phospholipase A2

Other Notes

Small volumes of PLA2G2D recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLA2G2D purchase

MBS142467 is a recombinant protein targeting PLA2G2D. Also known as Recombinant Human Secreted Phospholipase A2-IID. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PLA2G2D. It may not necessarily be applicable to this product.

NCBI GI #
425854812
NCBI GeneID
26279
NCBI Accession #
NP_001258743.1
UniProt Primary Accession #
Q9UNK4
UniProt Secondary Accession #
Q9UK01; A8K2Z1; B1AEL9
UniProt Related Accession #
Q9UNK4
GenBank Nucleotide #
NM_001271814.1
NCBI Official Full Name
group IID secretory phospholipase A2 isoform 2
NCBI Official Synonym Full Names
phospholipase A2, group IID
NCBI Official Symbol
PLA2G2D
NCBI Official Synonym Symbols
SPLASH; sPLA2S; PLA2IID; sPLA2-IID
UniProt Protein Name
Group IID secretory phospholipase A2
UniProt Synonym Protein Names
PLA2IID; Phosphatidylcholine 2-acylhydrolase 2D; Secretory-type PLA, stroma-associated homolog
Protein Family
Group IID secretory phospholipase
UniProt Gene Name
PLA2G2D
UniProt Synonym Gene Names
SPLASH; GIID sPLA2; sPLA2-IID
UniProt Entry Name
PA2GD_HUMAN
NCBI Protein Information
group IID secretory phospholipase A2; GIID sPLA2; phosphatidylcholine 2-acylhydrolase 2D; secretory phospholipase A2s; secretory-type PLA, stroma-associated homolog

NCBI Summary for PLA2G2D

This gene encodes a secreted member of the phospholipase A2 family, and is found in a cluster of related family members on chromosome 1. Phospholipase A2 family members hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce lysophospholipids and free fatty acid. This gene may be involved in inflammation and immune response, and in weight loss associated with chronic obstructive pulmonary disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
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UniProt Comments for PLA2G2D

PLA2G2D: PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2- linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined. Belongs to the phospholipase A2 family.

Protein type: Lipid Metabolism - arachidonic acid; Secreted, signal peptide; Lipid Metabolism - ether lipid; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - linoleic acid; Phospholipase; Secreted; Lipid Metabolism - glycerophospholipid; EC 3.1.1.4

Chromosomal Location of Human Ortholog: 1p36.12

Cellular Component: extracellular region

Molecular Function: phospholipase A2 activity; calcium ion binding

Biological Process: phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process; inflammatory response; lipid catabolic process
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Research Articles on PLA2G2D

1. sPLA(2)-IID is present at the head and midpiece in the human sperm, and its activation seems to be involved in acrosomal exocytosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PLA2G2D recombinant protein

 Reference Product  PubMed Publications
 PTGS2 recombinant protein  >2 publications with PLA2G2D and PTGS2
 ALOX12 recombinant protein  >1 publications with PLA2G2D and ALOX12
 PTGS1 recombinant protein  >1 publications with PLA2G2D and PTGS1
 PLA2G7 recombinant protein  >1 publications with PLA2G2D and PLA2G7

Pathways associated with PLA2G2D recombinant protein

 Products by Pathway  Pathway Diagram
 Acyl Chain Remodelling Of PC Pathway antibodies  Acyl Chain Remodelling Of PC Pathway Diagram
 Acyl Chain Remodelling Of PE Pathway antibodies  Acyl Chain Remodelling Of PE Pathway Diagram
 Acyl Chain Remodelling Of PG Pathway antibodies  Acyl Chain Remodelling Of PG Pathway Diagram
 Acyl Chain Remodelling Of PI Pathway antibodies  Acyl Chain Remodelling Of PI Pathway Diagram
 Acyl Chain Remodelling Of PS Pathway antibodies  Acyl Chain Remodelling Of PS Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Ether Lipid Metabolism Pathway antibodies  Ether Lipid Metabolism Pathway Diagram
 Ether Lipid Metabolism Pathway antibodies  Ether Lipid Metabolism Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram

Diseases associated with PLA2G2D recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >5 publications with PLA2G2D and Inflammation
 Lung Diseases Antibodies  >4 publications with PLA2G2D and Lung Diseases
 Adenocarcinoma Antibodies  >2 publications with PLA2G2D and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >2 publications with PLA2G2D and Cardiovascular Diseases
 Weight Loss Antibodies  >2 publications with PLA2G2D and Weight Loss
 Necrosis Antibodies  >2 publications with PLA2G2D and Necrosis
 Myocardial Infarction Antibodies  >1 publications with PLA2G2D and Myocardial Infarction
 Liver Neoplasms Antibodies  >1 publications with PLA2G2D and Liver Neoplasms
 Heart Diseases Antibodies  >1 publications with PLA2G2D and Heart Diseases
 Liver Diseases Antibodies  >1 publications with PLA2G2D and Liver Diseases

Organs/Tissues associated with PLA2G2D recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with PLA2G2D and Blood
 Kidney Antibodies  >2 publications with PLA2G2D and Kidney
 Lymph Node Antibodies  >1 publications with PLA2G2D and Lymph Node
 Lung Antibodies  >1 publications with PLA2G2D and Lung
 Spleen Antibodies  >1 publications with PLA2G2D and Spleen
 Intestine Antibodies  >1 publications with PLA2G2D and Intestine
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