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Secreted Phospholipase A2-XII (PLA2G12) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS142471

Secreted Phospholipase A2-XII Human Recombiannt was produced with N-terminal His-Tag. PLA2G12 His-Tagged Fusion Protein is 20.6 kDa containing 167 amino acid residues of the human secreted phospholipase A2-XII and 16 additional amino acid residues – His-Tag… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Secreted Phospholipase A2-XII (PLA2G12), Recombinant Protein
Full Product Name
Recombinant Human Secreted Phospholipase A2-XII
Product Gene Name
PLA2G12 recombinant protein
Product Synonym Names
PLA2G12 Human; Secreted Phospholipase A2-XII Human Recombinant; Group XIIA secretory phospholipase A2; EC 3.1.1.4; Phosphatidylcholine 2-acylhydrolase GXII; GXII sPLA2; PLA2G12; sPLA2-XII; PLA2G12A
Sequence
MRGSHHHHHH GMASHM QEQA QTTDWRATLK TIRNGVHKID TYLNAALDLL   GGEDGLCQYK CSDGSKPFPR YGYKPSPPNG CGSPLFGVHL NIGIPSLTKC CNQHDRCYET CGKSKNDCDE EFQYCLSKIC RDVQKTLGLT Q HVQACETTVE LLFDSVIHLG CKPYLDSQRA ACRCHYEEKT DL
Host
E Coli
Form/Format
Filtered (0.4 um) and lyophilized from 0.5 mg/ml in 0.01M Tris buffer pH 8.6.
Filtered White lyophilized (freeze-dried) powder.
Purity/Purification
Greater than 95% as determined by SDS PAGE.
Preparation and Storage
Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.
OMIM
611652
3D Structure
ModBase 3D Structure for Q9BZM1
Solubility
It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it on cell culture.

Product Categories/Family for PLA2G12 recombinant protein

Enzymes; Secreted Phospholipase A2
Applications Tested/Suitable for PLA2G12 recombinant protein
Western Blot (WB)

Other Notes

Small volumes of PLA2G12 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLA2G12 purchase

MBS142471 is a recombinant protein targeting PLA2G12. Also known as Recombinant Human Secreted Phospholipase A2-XII. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PLA2G12. It may not necessarily be applicable to this product.

NCBI GI #
21361944
NCBI GeneID
81579
NCBI Accession #
NP_110448.2
UniProt Primary Accession #
Q9BZM1
UniProt Secondary Accession #
Q9BZ89
UniProt Related Accession #
Q9BZM1
GenBank Nucleotide #
NM_030821.4
NCBI Official Full Name
group XIIA secretory phospholipase A2
NCBI Official Synonym Full Names
phospholipase A2, group XIIA
NCBI Official Symbol
PLA2G12A
NCBI Official Synonym Symbols
GXII; ROSSY; PLA2G12
UniProt Protein Name
Group XIIA secretory phospholipase A2
UniProt Synonym Protein Names
Phosphatidylcholine 2-acylhydrolase 12A
UniProt Gene Name
PLA2G12A
UniProt Synonym Gene Names
PLA2G12; GXII sPLA2; sPLA2-XII
UniProt Entry Name
PG12A_HUMAN
NCBI Protein Information
group XIIA secretory phospholipase A2; GXII sPLA2; group XII secreted phospholipase A2; group XIIA secreted phospholipase A2; phosphatidylcholine 2-acylhydrolase 12A; phospholipase A2, group XII; sPLA2-XII

NCBI Summary for PLA2G12

Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008]
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UniProt Comments for PLA2G12

PLA2G12A: PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl- phosphatidylcholine or -phosphatidylethanolamine. Belongs to the phospholipase A2 family.

Protein type: Phospholipase; Lipid Metabolism - linoleic acid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - ether lipid; Secreted, signal peptide; Endoplasmic reticulum; Lipid Metabolism - arachidonic acid; EC 3.1.1.4; Secreted; Lipid Metabolism - alpha-linolenic acid

Chromosomal Location of Human Ortholog: 4q25

Cellular Component: Golgi apparatus; endoplasmic reticulum; extracellular region

Molecular Function: calcium-dependent phospholipase A2 activity; calcium ion binding

Biological Process: phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process; lipid catabolic process
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Research Articles on PLA2G12

1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PLA2G12 recombinant protein

 Reference Product  PubMed Publications
 PTGS2 recombinant protein  >1 publications with PLA2G12 and PTGS2

Pathways associated with PLA2G12 recombinant protein

 Products by Pathway  Pathway Diagram
 Acyl Chain Remodelling Of PC Pathway antibodies  Acyl Chain Remodelling Of PC Pathway Diagram
 Acyl Chain Remodelling Of PE Pathway antibodies  Acyl Chain Remodelling Of PE Pathway Diagram
 Acyl Chain Remodelling Of PG Pathway antibodies  Acyl Chain Remodelling Of PG Pathway Diagram
 Acyl Chain Remodelling Of PI Pathway antibodies  Acyl Chain Remodelling Of PI Pathway Diagram
 Acyl Chain Remodelling Of PS Pathway antibodies  Acyl Chain Remodelling Of PS Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Ether Lipid Metabolism Pathway antibodies  Ether Lipid Metabolism Pathway Diagram
 Ether Lipid Metabolism Pathway antibodies  Ether Lipid Metabolism Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram

Diseases associated with PLA2G12 recombinant protein

 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >1 publications with PLA2G12 and Fatty Liver
 Inflammation Antibodies  >1 publications with PLA2G12 and Inflammation
 Hypertrophy Antibodies  >1 publications with PLA2G12 and Hypertrophy
 Hyperplasia Antibodies  >1 publications with PLA2G12 and Hyperplasia
 Necrosis Antibodies  >1 publications with PLA2G12 and Necrosis

Organs/Tissues associated with PLA2G12 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >2 publications with PLA2G12 and Liver
 Blood Antibodies  >2 publications with PLA2G12 and Blood
 Spleen Antibodies  >1 publications with PLA2G12 and Spleen
 Eye Antibodies  >1 publications with PLA2G12 and Eye
 Intestine Antibodies  >1 publications with PLA2G12 and Intestine
 Heart Antibodies  >1 publications with PLA2G12 and Heart
 Muscle Antibodies  >1 publications with PLA2G12 and Muscle
 Vascular Antibodies  >1 publications with PLA2G12 and Vascular
 Lung Antibodies  >1 publications with PLA2G12 and Lung
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