Human UBE2L6 Recombinant Protein – Cat# MBS142488

Ubiquitin Conjugating Enzyme E2L 6 (UBE2L6) Human Recombinant Protein

Name: UBE2L6 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS142488
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS142488

Description: UBE2L6 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 188 amino acids (1-152 a.a.) & having a molecular mass of 21.7 kDa. The UBE2L6 is fused to a 36 amino acid His Tag at N-terminus and purified… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Ubiquitin Conjugating Enzyme E2L 6 (UBE2L6), Recombinant Protein

Full Product Name

Recombinant Human Ubiquitin Conjugating Enzyme E2L 6

Product Gene Name

UBE2L6 recombinant protein

Product Synonym Names

UBE2L6 Human; Ubiquitin Conjugating Enzyme E2L 6 Human Recombinant; RIG-B; UBCH8; MGC40331; UBE2L6; Ubiquitin/ISG15-conjugating enzyme E2 L6; Ubiquitin-protein ligase L6; Ubiquitin carrier protein L6; Retinoic acid-induced gene B protein

Sequence

MRGSHHH HHH GMASMTGGQQ MGRDLYDDDD KDRWGS MASM RVVKELEDLQ KKPPPYLRNL SSDDANVLVW HALLLPDQPP YHLKAFNLRI SFPPEYPFKP PMIKFTTKIY HPNVDENGQI CLPIISSENW KPCTKTCQVL EALNVLVNRP NIREPLRMDL ADLLTQNPEL FRKNAEEFTL RFGVDRPS

Host

E Coli

Form/Format

The protein contains 20mM Tris pH-8, 0.1mM PMSF, 1mM DTT, and 10% glycerol.
Sterile filtered colorless solution.

Purity/Purification

Greater than 90% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Molecular Weight

10,086 Da

OMIM

603890

3D Structure

ModBase 3D Structure for O14933

Product Categories/Family for UBE2L6 recombinant protein

Enzymes; Ubiquitin Conjugating Enzyme

Other Notes

Small volumes of UBE2L6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UBE2L6 purchase

MBS142488 is a recombinant protein targeting UBE2L6. Also known as Recombinant Human Ubiquitin Conjugating Enzyme E2L 6. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for UBE2L6. It may not necessarily be applicable to this product.

NCBI GI #

4759282

NCBI GeneID

9246

NCBI Accession #

NP_004214.1

UniProt Primary Accession #

O14933

UniProt Secondary Accession #

Q8N5D8; Q9UEZ0; A6NDM6; A8MY53

UniProt Related Accession #

O14933

GenBank Nucleotide #

NM_004223.4

NCBI Official Full Name

ubiquitin/ISG15-conjugating enzyme E2 L6 isoform 1

NCBI Official Synonym Full Names

ubiquitin-conjugating enzyme E2L 6

NCBI Official Symbol

UBE2L6

NCBI Official Synonym Symbols

RIG-B; UBCH8

UniProt Protein Name

Ubiquitin/ISG15-conjugating enzyme E2 L6

UniProt Synonym Protein Names

Retinoic acid-induced gene B protein; RIG-B; UbcH8; Ubiquitin carrier protein L6; Ubiquitin-protein ligase L6

Protein Family

Ubiquitin/ISG15-conjugating enzyme

UniProt Gene Name

UBE2L6

UniProt Synonym Gene Names

UBCH8; RIG-B

UniProt Entry Name

UB2L6_HUMAN

NCBI Protein Information

ubiquitin/ISG15-conjugating enzyme E2 L6; retinoic acid induced gene B protein; retinoic acid-induced gene B protein; ubiquitin carrier protein L6; ubiquitin-protein ligase L6

NCBI Summary for UBE2L6

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]

UniProt Comments for UBE2L6

UBE2L6: Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. Belongs to the ubiquitin-conjugating enzyme family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ligase; Ubiquitin conjugating system; EC 6.3.2.19; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 11q12

Cellular Component: cytosol

Molecular Function: protein binding; ISG15 conjugating enzyme activity; ubiquitin-protein ligase activity; ligase activity

Biological Process: ISG15-protein conjugation; modification-dependent protein catabolic process; cytokine and chemokine mediated signaling pathway; innate immune response; protein ubiquitination; protein modification process; negative regulation of interferon type I production

Research Articles on UBE2L6

1. study reports that UBCH8 and UBE2G1 and UBE2G2 cooperate with CRL4Cdt2 in promoting the polyubiquitylation and subsequent degradation of p21 and Cdt1, respectively

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with UBE2L6 recombinant protein

Reference Product	PubMed Publications
ISG15 recombinant protein	>13 publications with UBE2L6 and ISG15
STAT1 recombinant protein	>1 publications with UBE2L6 and STAT1
HERC5 recombinant protein	>1 publications with UBE2L6 and HERC5
DDX58 recombinant protein	>1 publications with UBE2L6 and DDX58

Pathways associated with UBE2L6 recombinant protein

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies	Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies	Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies	Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
ISG15 Antiviral Mechanism Pathway antibodies	ISG15 Antiviral Mechanism Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Interferon Signaling Pathway antibodies	Interferon Signaling Pathway Diagram
Negative Regulators Of RIG-I/MDA5 Signaling Pathway antibodies	Negative Regulators Of RIG-I/MDA5 Signaling Pathway Diagram

Diseases associated with UBE2L6 recombinant protein

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>3 publications with UBE2L6 and Breast Neoplasms
Inflammation Antibodies	>3 publications with UBE2L6 and Inflammation
Influenza, Human Antibodies	>2 publications with UBE2L6 and Influenza, Human
Poisoning Antibodies	>1 publications with UBE2L6 and Poisoning
Brain Diseases Antibodies	>1 publications with UBE2L6 and Brain Diseases
Hypertrophy Antibodies	>1 publications with UBE2L6 and Hypertrophy
Hyperplasia Antibodies	>1 publications with UBE2L6 and Hyperplasia
Weight Loss Antibodies	>1 publications with UBE2L6 and Weight Loss

Organs/Tissues associated with UBE2L6 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>6 publications with UBE2L6 and Blood
Lung Antibodies	>2 publications with UBE2L6 and Lung
Bone Antibodies	>1 publications with UBE2L6 and Bone
Lymph Node Antibodies	>1 publications with UBE2L6 and Lymph Node
Connective Tissue Antibodies	>1 publications with UBE2L6 and Connective Tissue
Kidney Antibodies	>1 publications with UBE2L6 and Kidney
Lymph Antibodies	>1 publications with UBE2L6 and Lymph
Embryonic Tissue Antibodies	>1 publications with UBE2L6 and Embryonic Tissue
Intestine Antibodies	>1 publications with UBE2L6 and Intestine