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Zinc Finger Protein GLIS3 (GLIS3) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1425899

This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the… More details

$1660 / 0.02 mg (E-Coli) +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Zinc finger protein GLIS3 (Glis3), Recombinant Protein
Full Product Name
Recombinant Mouse Zinc finger protein GLIS3 (Glis3)
Product Gene Name
Glis3 recombinant protein
Product Synonym Gene Name
Glis3
Sequence
MMVQRLGPIS PPASQVSTAC KQISPSLPRA VNAANLNRPP SDTRSVILQE SLVSTTLSLT ESQSALSVKQ EWSQSYRAFP SLSSSHSSQN GTDLGDLLSL PPGTPVSGNS VSNSLPPYLF GMENSHSPYP SPRHSATRAH STRSKKRALS LSPLSDGIGI DFNTIIRTSP TSLVAYINGP RASPANLSPQ SEVYGHFLGV RGSCIPQSCA VASGQKGILV ASGGHTLPGY GEDGTLEYER MQQLEHGGLQ PGPVNNMVLQ PGLPGQDGQT ANMLKTERLE EFPASALDLP SALPLPLPPP QGPPPPYHAH PHLHHPELLP HTQSLSLAQT GLEEDGEMED SGGKHCCRWI DCSALYDQQE ELVRHIEKVH IDQRKGEDFT CFWTGCPRRY KPFNARYKLL IHMRVHSGEK PNKCTFEGCK KAFSRLENLK IHLRSHTGEK PYLCQHPGCQ KAFSNSSDRA KHQRTHLDTK PYACQIPGCT KRYTDPSSLR KHVKAHSSRE QQARKKLRSS TELHPDLLTD CLAVQPLQPA TSPGDAADHT VGHSPGPGPG PGPGAELYSA PIFASNHSTR SGTAAGAGPP PHPVSHPSPG HNVQGSPHNP SSQLPPLTAV DAGAERFAPP TPSPHHISPG RVPAPPSLLQ RAQAPHSQQP PGSLLKPYQP ETNSSFQPNG IHVHGFYGQL QTFCPPHYPD SQRTVPPSGS CSMVPSFEDC LVPTSMGQAG FDVFHRAFST HSGITVYDLP SASSSLFGES LRSGPEDPTF LQLSAVDRCP SQLSSVYTEG
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
72,374 Da
Sequence Positions
1-780, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q6XP49
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Glis3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Glis3 purchase

MBS1425899 is a recombinant protein targeting Glis3. Also known as Recombinant Mouse Zinc finger protein GLIS3 (Glis3). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Glis3. It may not necessarily be applicable to this product.

NCBI GI #
569007036
NCBI GeneID
226075
NCBI Accession #
XP_006527048.1
UniProt Primary Accession #
Q6XP49
UniProt Secondary Accession #
Q8BI60
UniProt Related Accession #
Q6XP49
GenBank Nucleotide #
XM_006526985.3
NCBI Official Full Name
zinc finger protein GLIS3 isoform X2
NCBI Official Synonym Full Names
GLIS family zinc finger 3
NCBI Official Symbol
Glis3
NCBI Official Synonym Symbols
4833409N03Rik; E330013K21Rik
UniProt Protein Name
Zinc finger protein GLIS3
UniProt Synonym Protein Names
GLI-similar 3
Protein Family
Zinc finger protein
UniProt Gene Name
Glis3
NCBI Protein Information
zinc finger protein GLIS3

NCBI Summary for Glis3

This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein which contains multiple C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the transcriptional regulation of insulin. It is thought to enhance GLI-RE-dependent transcription by binding to the GLI-RE consensus sequence (GACCACCCAC). Mutations in a similar gene in human have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
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UniProt Comments for Glis3

Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3'.

Research Articles on Glis3

1. The observations suggest that GLIS3 promotes the gonocyte-to- spermatogonial stem cells transition and is a critical regulator of the dynamics of early postnatal spermatogenesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Glis3 recombinant protein

 Reference Product  PubMed Publications
 FLNA recombinant protein  >12 publications with Glis3 and FLNA

Pathways associated with Glis3 recombinant protein

 Products by Pathway  Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram

Diseases associated with Glis3 recombinant protein

 Disease Name  Pubmed Publications
 Diabetes Mellitus, Type 2 Antibodies  >14 publications with Glis3 and Diabetes Mellitus, Type 2
 Kidney Diseases Antibodies  >7 publications with Glis3 and Kidney Diseases
 Diabetes Mellitus, Neonatal, with Congenital Hypothyroidism Antibodies  >6 publications with Glis3 and Diabetes Mellitus, Neonatal, with Congenital Hypothyroidism
 Diabetes Mellitus, Type 1 Antibodies  >5 publications with Glis3 and Diabetes Mellitus, Type 1
 Fibrosis Antibodies  >4 publications with Glis3 and Fibrosis
 Brain Diseases Antibodies  >3 publications with Glis3 and Brain Diseases
 Congenital Abnormalities Antibodies  >3 publications with Glis3 and Congenital Abnormalities
 Disease Models, Animal Antibodies  >2 publications with Glis3 and Disease Models, Animal
 Inflammation Antibodies  >2 publications with Glis3 and Inflammation
 Liver Diseases Antibodies  >2 publications with Glis3 and Liver Diseases

Organs/Tissues associated with Glis3 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >8 publications with Glis3 and Pancreas
 Brain Antibodies  >3 publications with Glis3 and Brain
 Embryonic Tissue Antibodies  >3 publications with Glis3 and Embryonic Tissue
 Skin Antibodies  >1 publications with Glis3 and Skin
 Eye Antibodies  >1 publications with Glis3 and Eye
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