Human LHRH Synthetic Protein – Cat# MBS142655

Leutenizing Hormone Releasing Hormone (LHRH) Human Synthetic Protein

Name: LHRH Synthetic Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS142655
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS142655

Description: Lutenizing Hormone Releasing Hormone Human Synthetic is a single, non-glycosylated, polypeptide chain containing 10 amino acids and having a molecular mass of 1182..3 Dalton. The molecular formula is C55H75N17O13C2H4O2. The CAS Number is… More details

$250 / 10 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Leutenizing hormone Releasing Hormone (LHRH), Synthetic Protein

Full Product Name

Human Leutenizing hormone Releasing Hormone (Gonadorelin)

Product Gene Name

LHRH synthetic protein

Product Synonym Names

LHRH Human; Luteinizing Hormone Releasing Hormone Human; Progonadoliberin-1; Progonadoliberin I; LHRH; GRH; GNRH; LNRH

Sequence

Pyr-His-Tr p-Ser-Tyr- Gly-Leu-Ar g-Pro-Gly- NH2

Host

Escherichia Coli

Form/Format

The LHRH was lyophilized from a concentrated (1 mg/ml) solution with no additives.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 98.0% as determined by RP-HPLC.

Preparation and Storage

Lyophilized LHRH although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution LNRH should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Molecular Weight

10,380 Da

OMIM

152760

3D Structure

ModBase 3D Structure for P01148

Solubility

It is recommended to reconstitute the lyophilized LHRH in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. The LHRH is also soluble in a 1% glacial acetic acid.

Product Categories/Family for LHRH synthetic protein

Hormones; Hormones; LHRH

Other Notes

Small volumes of LHRH synthetic protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LHRH purchase

MBS142655 is a synthetic protein targeting LHRH. Also known as Human Leutenizing hormone Releasing Hormone (Gonadorelin). Host: Escherichia Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for LHRH. It may not necessarily be applicable to this product.

NCBI GI #

133908612

NCBI GeneID

2796

NCBI Accession #

NP_001076580.1

UniProt Primary Accession #

P01148

UniProt Secondary Accession #

A0AVP0

UniProt Related Accession #

P01148

GenBank Nucleotide #

NM_001083111.1

NCBI Official Full Name

progonadoliberin-1 isoform 2 preproprotein

NCBI Official Synonym Full Names

gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)

NCBI Official Symbol

GNRH1

NCBI Official Synonym Symbols

GRH; GNRH; HH12; LHRH; LNRH

UniProt Protein Name

Progonadoliberin-1

UniProt Synonym Protein Names

Progonadoliberin ICleaved into the following 2 chains:Gonadoliberin-1Alternative name(s):Gonadoliberin I; Gonadorelin; Gonadotropin-releasing hormone I; GnRH-I; Luliberin I; Luteinizing hormone-releasing hormone I; LH-RH I

UniProt Gene Name

GNRH1

UniProt Synonym Gene Names

GNRH; GRH; LHRH; GnRH-I; LH-RH I

UniProt Entry Name

GON1_HUMAN

NCBI Protein Information

progonadoliberin-1; GnRH-associated peptide 1; gonadotropin-releasing hormone 1 (leutinizing-releasing hormone); luliberin I; progonadoliberin I; prolactin release-inhibiting factor

NCBI Summary for LHRH

The protein encoded by this gene is secreted and then cleaved to form the 10 aa luteinizing hormone-releasing hormone (LHRH, also known as gonadoliberin-1), and prolactin release-inhibiting factor (also known as GnRH-associated peptide 1). LHRH stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutation in this gene are associated with hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2012]

UniProt Comments for LHRH

GNRH1: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones. Belongs to the GnRH family.

Protein type: Hormone; Cell cycle regulation; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8p21-p11.2

Cellular Component: extracellular space; extracellular region

Molecular Function: hormone activity; luteinizing hormone-releasing factor activity

Biological Process: negative regulation of cell proliferation; ovulation cycle; response to ethanol; cell-cell signaling; regulation of gene expression; multicellular organismal development; female pregnancy; signal transduction; negative regulation of apoptosis; response to corticosteroid stimulus

Disease: Hypogonadotropic Hypogonadism 7 With Or Without Anosmia

Research Articles on LHRH

1. Data indicate that the gene expression pattern is profoundly different between human chorionic gonadotropin (hCG) and gonadotropin-releasing hormone (GnRH) agonist.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with LHRH synthetic protein

Reference Product	PubMed Publications
GNRH2 synthetic protein	>65 publications with LHRH and GNRH2
GNRHR synthetic protein	>32 publications with LHRH and GNRHR
FSH synthetic protein	>24 publications with LHRH and FSH
KISS1R synthetic protein	>19 publications with LHRH and KISS1R
PROK2 synthetic protein	>12 publications with LHRH and PROK2
GNRHR2 synthetic protein	>1 publications with LHRH and GNRHR2
TRH synthetic protein	>1 publications with LHRH and TRH

Pathways associated with LHRH synthetic protein

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies	Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
GnRH Signaling Pathway antibodies	GnRH Signaling Pathway Diagram
GnRH Signaling Pathway antibodies	GnRH Signaling Pathway Diagram
Hormone Ligand-binding Receptors Pathway antibodies	Hormone Ligand-binding Receptors Pathway Diagram

Diseases associated with LHRH synthetic protein

Disease Name	Pubmed Publications
Hypogonadism Antibodies	>32 publications with LHRH and Hypogonadism
Disorders of Sex Development Antibodies	>12 publications with LHRH and Disorders of Sex Development
Urogenital Abnormalities Antibodies	>12 publications with LHRH and Urogenital Abnormalities
Ovarian Diseases Antibodies	>6 publications with LHRH and Ovarian Diseases
Infertility, Female Antibodies	>5 publications with LHRH and Infertility, Female
Nervous System Diseases Antibodies	>5 publications with LHRH and Nervous System Diseases
Breast Neoplasms Antibodies	>4 publications with LHRH and Breast Neoplasms
Chromosome Aberrations Antibodies	>4 publications with LHRH and Chromosome Aberrations
Infertility, Male Antibodies	>4 publications with LHRH and Infertility, Male
Genital Diseases, Male Antibodies	>3 publications with LHRH and Genital Diseases, Male

Organs/Tissues associated with LHRH synthetic protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>107 publications with LHRH and Brain
Blood Antibodies	>45 publications with LHRH and Blood
Testis Antibodies	>15 publications with LHRH and Testis
Prostate Antibodies	>5 publications with LHRH and Prostate
Uterus Antibodies	>3 publications with LHRH and Uterus
Placenta Antibodies	>2 publications with LHRH and Placenta
Intestine Antibodies	>2 publications with LHRH and Intestine
Eye Antibodies	>2 publications with LHRH and Eye
Stomach Antibodies	>1 publications with LHRH and Stomach
Mammary Gland Antibodies	>1 publications with LHRH and Mammary Gland