Inhibin-Alpha A Chain (INHA) Human Recombinant Protein

This gene encodes the alpha subunit of inhibins A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion.[provided by RefSeq, Dec 2010]

INHA: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: photoreceptor inner segment; photoreceptor outer segment; cell soma; extracellular region

Molecular Function: protein binding; growth factor activity; protein heterodimerization activity; hormone activity; cytokine activity; transforming growth factor beta receptor binding; receptor binding

Biological Process: hemoglobin biosynthetic process; negative regulation of B cell differentiation; nervous system development; regulation of cell cycle; male gonad development; signal transduction; negative regulation of follicle-stimulating hormone secretion; regulation of cell proliferation; negative regulation of interferon-gamma biosynthetic process; negative regulation of cell cycle; response to external stimulus; regulation of apoptosis; cell surface receptor linked signal transduction; negative regulation of macrophage differentiation; cell-cell signaling; ovarian follicle development; regulation of MAPKKK cascade; erythrocyte differentiation; negative regulation of phosphorylation; positive regulation of follicle-stimulating hormone secretion; cell differentiation; cell cycle arrest; skeletal development; cell development