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Adseverin (SCIN) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1427097

MBS1427097 is a recombinant protein targeting SCIN. Also known as Recombinant Human Adseverin (SCIN). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$455 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Adseverin (SCIN), Recombinant Protein
Full Product Name
Recombinant Human Adseverin (SCIN)
Product Gene Name
SCIN recombinant protein
Product Synonym Gene Name
SCIN
Sequence
MARELYHEEF ARAGKQAGLQ VWRIEKLELV PVPQSAHGDF YVGDAYLVLH TAKTSRGFTY HLHFWLGKEC SQDESTAAAI FTVQMDDYLG GKPVQNRELQ GYESNDFVSY FKGGLKYKAG GVASGLNHVL TNDLTAKRLL HVKGRRVVRA TEVPLSWDSF NKGDCFIIDL GTEIYQWCGS SCNKYERLKA NQVATGIRYN ERKGRSELIV VEEGSEPSEL IKVLGEKPEL PDGGDDDDII ADISNRKMAK LYMVSDASGS MRVTVVAEEN PFSMAMLLSE ECFILDHGAA KQIFVWKGKD ANPQERKAAM KTAEEFLQQM NYSKNTQIQV LPEGGETPIF KQFFKDWRDK DQSDGFGKVY VTEKVAQIKQ IPFDASKLHS SPQMAAQHNM VDDGSGKVEI WRVENNGRIQ VDQNSYGEFY GGDCYIILYT YPRGQIIYTW QGANATRDEL TTSAFLTVQL DRSLGGQAVQ IRVSQGKEPV HLLSLFKDKP LIIYKNGTSK KGGQAPAPPT RLFQVRRNLA SITRIVEVDV DANSLNSNDV FVLKLPQNSG YIWVGKGASQ EEEKGAEYVA SVLKCKTLRI QEGEEPEEFW NSLGGKKDYQ TSPLLETQAE DHPPRLYGCS NKTGRFVIEE IPGEFTQDDL AEDDVMLLDA WEQIFIWIGK DANEVEKKES LKSAKMYLET DPSGRDKRTP IVIIKQGHEP PTFTGWFLGW DSSKW
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
52,814 Da
Sequence Positions
1-715, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
613416
3D Structure
ModBase 3D Structure for Q9Y6U3
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of SCIN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SCIN. It may not necessarily be applicable to this product.

NCBI GI #
162951877
NCBI GeneID
85477
NCBI Accession #
NP_001106177.1
UniProt Primary Accession #
Q9Y6U3
UniProt Secondary Accession #
Q8NBZ6; Q8WU97; Q96JC7; Q96PY2; A8K2U8
UniProt Related Accession #
Q9Y6U3
GenBank Nucleotide #
NM_001112706.2
NCBI Official Full Name
adseverin isoform 1
NCBI Official Synonym Full Names
scinderin
NCBI Official Symbol
SCIN
UniProt Protein Name
Adseverin
UniProt Synonym Protein Names
Scinderin
Protein Family
Adseverin
UniProt Gene Name
SCIN
UniProt Synonym Gene Names
KIAA1905
NCBI Protein Information
adseverin

NCBI Summary for SCIN

SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 [PubMed 11568009]).[supplied by OMIM, May 2010]

UniProt Comments for SCIN

Ca2+-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:8547642, PubMed:26365202). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (). In vitro, also has barbed end capping and nucleating activities in the presence of Ca2+. Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (). Regulates chondrocyte proliferation and differentiation (). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009).
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Research Articles on SCIN

1. Data suggest that scinderin (Scin) played a vital role in the development of developmental dysplasia of the hip (DDH).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with SCIN recombinant protein

 Products by Pathway  Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Viral Carcinogenesis Pathway antibodies  Viral Carcinogenesis Pathway Diagram
 Viral Carcinogenesis Pathway antibodies  Viral Carcinogenesis Pathway Diagram

Diseases associated with SCIN recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with SCIN and Nervous System Diseases
 Inflammation Antibodies  >4 publications with SCIN and Inflammation
 Poisoning Antibodies  >2 publications with SCIN and Poisoning
 Disease Models, Animal Antibodies  >1 publications with SCIN and Disease Models, Animal
 Heart Defects, Congenital Antibodies  >1 publications with SCIN and Heart Defects, Congenital
 Prostatic Neoplasms Antibodies  >1 publications with SCIN and Prostatic Neoplasms
 Liver Neoplasms Antibodies  >1 publications with SCIN and Liver Neoplasms
 Adenoma, Liver Cell Antibodies  >1 publications with SCIN and Adenoma, Liver Cell
 Abnormalities, Multiple Antibodies  >1 publications with SCIN and Abnormalities, Multiple
 Congenital Abnormalities Antibodies  >1 publications with SCIN and Congenital Abnormalities

Organs/Tissues associated with SCIN recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >3 publications with SCIN and Lung
 Kidney Antibodies  >2 publications with SCIN and Kidney
 Trachea Antibodies  >1 publications with SCIN and Trachea
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