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Female Germline-Specific Tumor Suppressor Gld-1 (gld-1) Caenorhabditis Elegans Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1427152

MBS1427152 is a recombinant protein targeting gld-1. Also known as Recombinant Caenorhabditis elegans Female germline-specific tumor suppressor gld-1 (gld-1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1240 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
PDF
Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
PDF
Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Female germline-specific tumor suppressor gld-1 (gld-1), Recombinant Protein
Full Product Name
Recombinant Caenorhabditis elegans Female germline-specific tumor suppressor gld-1 (gld-1)
Product Gene Name
gld-1 recombinant protein
Product Synonym Gene Name
gld-1
Sequence
MPSCTTPTYG VSTQLESQSS ESPSRSSVMT PTSLDGDNSP RKRFPIIDNV PADRWPSTRR DGWSSVRAPP PARLTLSTNN RHIMSPISSA YSQTPNSLLS PAMFNPKSRS IFSPTLPATP MSYGKSSMDK SLFSPTATEP IEVEATVEYL ADLVKEKKHL TLFPHMFSNV ERLLDDEIGR VRVALFQTEF PRVELPEPAG DMISITEKIY VPKNEYPDYN FVGRILGPRG MTAKQLEQDT GCKIMVRGKG SMRDKSKESA HRGKANWEHL EDDLHVLVQC EDTENRVHIK LQAALEQVKK LLIPAPEGTD ELKRKQLMEL AIINGTYRPM KSPNPARVMT AVPLLSPTPL RSSGPVLMSP TPGSGLPSTT FGGSILSPTL TASNLLGSNV FDYSLLSPSM FDSFSSLQLA SDLTFPKYPT TTSFVNSFPG LFTSASSFAN QTNTNVSPSG ASPSASSVNN TSF
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
50,586 Da
Sequence Positions
1-463, Full length
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q17339
Species
Caenorhabditis elegans
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of gld-1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for gld-1. It may not necessarily be applicable to this product.

NCBI GI #
17507875
NCBI GeneID
172532
NCBI Accession #
NP_492143.1
UniProt Primary Accession #
Q17339
UniProt Secondary Accession #
O02540
UniProt Related Accession #
Q17339
GenBank Nucleotide #
NM_059742.6
NCBI Official Full Name
Female germline-specific tumor suppressor gld-1
NCBI Official Symbol
gld-1
UniProt Protein Name
Female germline-specific tumor suppressor gld-1
UniProt Synonym Protein Names
Defective in germ line development protein 1
Protein Family
Female germline-specific tumor suppressor
UniProt Gene Name
gld-1
NCBI Protein Information
Female germline-specific tumor suppressor gld-1

UniProt Comments for gld-1

RNA-binding protein which recognizes the 5'-UACUCAU-3' RNA consensus sequence (PubMed:24838563). Binds sequences in both the 5'coding and the 3'-UTR region of rme-2 mRNA (PubMed:11562350). Binds sequences in the 3'-UTR region of cye-1 mRNA. Binds to cyb-2.1, cyb-2.2 and cyb-3 mRNA (PubMed:19758560). Binds sequences in the 3'-UTR region of tra-2 mRNA (PubMed:24838563). Germ line-specific tumor suppressor essential for oogenesis (PubMed:7601353). Controls the spatial pattern of translation of multiple oogenesis specific mRNAs (e.g. yolk receptor rme-2) by repression of translation during early meiotic prophase (leptotene to pachytene) and then derepression of translation during diplotene/ diakinesis, following its degradation. Also functions to promote the male sexual fate in the hermaphrodite germline but not the male germline (PubMed:7601353, PubMed:11562350, PubMed:24838563). Functions redundantly with gld-2 to promote the initiation of meiotic development and/or inhibit stem cell proliferation (PubMed:11562350). By regulating cye-1 expression, prevents entry into mitosis in meiotic germline cells (PubMed:19758560, PubMed:21455289).
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Research Articles on gld-1

1. glp-1 transcriptional targets lst-1 and sygl-1 are individually required for GLD-1 repression in stem cells; regulation of GLD-1 levels and pattern appears regional in the proliferative zone

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with gld-1 recombinant protein

 Products by Pathway  Pathway Diagram
 Programmed Cell Death Pathway antibodies  Programmed Cell Death Pathway Diagram

Diseases associated with gld-1 recombinant protein

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >3 publications with gld-1 and Brain Diseases

Organs/Tissues associated with gld-1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Embryo Antibodies  >20 publications with gld-1 and Embryo
 Unknown Developmental Stage Antibodies  >1 publications with gld-1 and Unknown Developmental Stage
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