Human PSPH Recombinant Protein – Cat# MBS142770

Phosphoserine Phosphatase (PSPH) Human Recombinant Protein

Name: PSPH Recombinant Protein; Phosphoserine Phosphatase; Human; MyBioSource
Brand: MyBioSource
SKU: MBS142770
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS142770

Description: Phosphoserine Phosphatase Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 225 amino acids and having a molecular mass of 25 kDa. PSP was overexpressed in E Coli and purified by conventional… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Phosphoserine Phosphatase (PSPH), Recombinant Protein

Full Product Name

Recombinant Human Phosphoserine Phosphatase

Product Gene Name

PSPH recombinant protein

Product Synonym Names

PSPH Human; Phosphoserine Phosphatase Human Recombinant; Phosphoserine phosphatase; EC 3.1.3.3; PSP; O-phosphoserine phosphohydrolase; PSPase; L-3-phosphoserine phosphatase; PSPH

Sequence

MVSHSELRKL FYSADAVCFD VDSTVIREEG IDELAKICGV EDAVSEMTRR AMGGAVPFKA ALTERLALIQ PSREQVQRLI AEQPPHLTPG IRELVSRLQE RNVQVFLISG GFRSIVEHVA SKLNIPATNV FANRLKFYFN GEYAGFDETQ PTAESGGKGK VIKLLKEKFH FKKIIMIGDG ATDMEACPPA DAFIGFGGNV IRQQVKDNAK WYITDFVELL GELEE

Host

E Coli

Form/Format

The protein contains 20mM Hepes pH 7.5, 1mM DTT &100mM KCl2.
Sterile filtered colorless solution.

Purity/Purification

Greater than 95.0% as determined by(a)Analysis by RP-HPLC. (b)Analysis by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Molecular Weight

25,008 Da

OMIM

172480

3D Structure

ModBase 3D Structure for P78330

Product Categories/Family for PSPH recombinant protein

Protein Kinases; Enzymes; Phosphatase

Other Notes

Small volumes of PSPH recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PSPH purchase

MBS142770 is a recombinant protein targeting PSPH. Also known as Recombinant Human Phosphoserine Phosphatase. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PSPH. It may not necessarily be applicable to this product.

NCBI GI #

46249388

NCBI GeneID

5723

NCBI Accession #

NP_004568.2

UniProt Primary Accession #

P78330

UniProt Secondary Accession #

Q7Z3S5; B2RCR5

UniProt Related Accession #

P78330

GenBank Nucleotide #

NM_004577.3

NCBI Official Full Name

phosphoserine phosphatase

NCBI Official Synonym Full Names

phosphoserine phosphatase

NCBI Official Symbol

PSPH

NCBI Official Synonym Symbols

PSP; PSPHD

UniProt Protein Name

Phosphoserine phosphatase

UniProt Synonym Protein Names

L-3-phosphoserine phosphatase; O-phosphoserine phosphohydrolase

Protein Family

Phosphoserine phosphatase

UniProt Gene Name

PSPH

UniProt Synonym Gene Names

PSP; PSPase

UniProt Entry Name

SERB_HUMAN

NCBI Protein Information

phosphoserine phosphatase; L-3-phosphoserine phosphatase; O-phosphoserine phosphohydrolase; PSPase

NCBI Summary for PSPH

The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome. [provided by RefSeq, Jul 2008]

UniProt Comments for PSPH

PSPH: Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates. Defects in PSPH are the cause of phosphoserine phosphatase deficiency (PSPHD)[MIM:614023]. A disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome. Belongs to the SerB family.

Protein type: EC 3.1.3.3; Motility/polarity/chemotaxis; Hydrolase; Amino Acid Metabolism - glycine, serine and threonine

Chromosomal Location of Human Ortholog: 7p11.2

Cellular Component: neuron projection; cytoplasm; cytosol

Molecular Function: protein homodimerization activity; phosphoserine phosphatase activity; magnesium ion binding; calcium ion binding

Biological Process: response to nutrient levels; L-serine biosynthetic process; dephosphorylation; L-serine metabolic process; response to mechanical stimulus; response to testosterone stimulus; amino acid biosynthetic process

Disease: Phosphoserine Phosphatase Deficiency

Research Articles on PSPH

1. phosphoserine phosphatase deficiency is associated with Neu-Laxova syndrome.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PSPH recombinant protein

Reference Product	PubMed Publications
PSAT1 recombinant protein	>7 publications with PSPH and PSAT1
SHMT1 recombinant protein	>6 publications with PSPH and SHMT1
CBS recombinant protein	>1 publications with PSPH and CBS
SHMT2 recombinant protein	>1 publications with PSPH and SHMT2

Pathways associated with PSPH recombinant protein

Products by Pathway	Pathway Diagram
Amino Acid Synthesis And Interconversion (transamination) Pathway antibodies	Amino Acid Synthesis And Interconversion (transamination) Pathway Diagram
Biosynthesis Of Amino Acids Pathway antibodies	Biosynthesis Of Amino Acids Pathway Diagram
Biosynthesis Of Amino Acids Pathway antibodies	Biosynthesis Of Amino Acids Pathway Diagram
Carbon Metabolism Pathway antibodies	Carbon Metabolism Pathway Diagram
Carbon Metabolism Pathway antibodies	Carbon Metabolism Pathway Diagram
Glycine, Serine And Threonine Metabolism Pathway antibodies	Glycine, Serine And Threonine Metabolism Pathway Diagram
Glycine, Serine And Threonine Metabolism Pathway antibodies	Glycine, Serine And Threonine Metabolism Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Amino Acids And Derivatives Pathway antibodies	Metabolism Of Amino Acids And Derivatives Pathway Diagram

Diseases associated with PSPH recombinant protein

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>4 publications with PSPH and Breast Neoplasms
Hypertension Antibodies	>2 publications with PSPH and Hypertension
Heart Diseases Antibodies	>2 publications with PSPH and Heart Diseases
Cardiovascular Diseases Antibodies	>2 publications with PSPH and Cardiovascular Diseases
Lung Neoplasms Antibodies	>1 publications with PSPH and Lung Neoplasms
Fetal Growth Retardation Antibodies	>1 publications with PSPH and Fetal Growth Retardation
Fatty Liver Antibodies	>1 publications with PSPH and Fatty Liver
Hyperplasia Antibodies	>1 publications with PSPH and Hyperplasia
Neural Tube Defects Antibodies	>1 publications with PSPH and Neural Tube Defects
Inflammation Antibodies	>1 publications with PSPH and Inflammation

Organs/Tissues associated with PSPH recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>8 publications with PSPH and Blood
Lung Antibodies	>6 publications with PSPH and Lung
Brain Antibodies	>6 publications with PSPH and Brain
Liver Antibodies	>3 publications with PSPH and Liver
Bone Antibodies	>2 publications with PSPH and Bone
Mouth Antibodies	>1 publications with PSPH and Mouth
Vascular Antibodies	>1 publications with PSPH and Vascular
Lymph Node Antibodies	>1 publications with PSPH and Lymph Node
Skin Antibodies	>1 publications with PSPH and Skin
Eye Antibodies	>1 publications with PSPH and Eye