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Lethal (3)malignant Brain Tumor-Like Protein 1 (L3MBTL1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1428047

This gene encodes the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. This gene product is localized to condensed chromosomes in mitotic… More details

$1615 / 0.02 mg (E-Coli) +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Lethal (3)malignant brain tumor-like protein 1 (L3MBTL1), Recombinant Protein
Full Product Name
Recombinant Human Lethal (3)malignant brain tumor-like protein 1 (L3MBTL1)
Product Gene Name
L3MBTL1 recombinant protein
Product Synonym Gene Name
L3MBTL1
Sequence
MRRREGHGTD SEMGQGPVRE SQSSDPPALQ FRISEYKPLN MAGVEQPPSP ELRQEGVTEY EDGGAPAGDG EAGPQQAEDH PQNPPEDPNQ DPPEDDSTCQ CQACGPHQAA GPDLGSSNDG CPQLFQERSV IVENSSGSTS ASELLKPMKK RKRREYQSPS EEESEPEAME KQEEGKDPEG QPTASTPESE EWSSSQPATG EKKECWSWES YLEEQKAITA PVSLFQDSQA VTHNKNGFKL GMKLEGIDPQ HPSMYFILTV AEVCGYRLRL HFDGYSECHD FWVNANSPDI HPAGWFEKTG HKLQPPKGYK EEEFSWSQYL RSTRAQAAPK HLFVSQSHSP PPLGFQVGMK LEAVDRMNPS LVCVASVTDV VDSRFLVHFD NWDDTYDYWC DPSSPYIHPV GWCQKQGKPL TPPQDYPDPD NFCWEKYLEE TGASAVPTWA FKVRPPHSFL VNMKLEAVDR RNPALIRVAS VEDVEDHRIK IHFDGWSHGY DFWIDADHPD IHPAGWCSKT GHPLQPPLGP REPSSASPGG CPPLSYRSLP HTRTSKYSFH HRKCPTPGCD GSGHVTGKFT AHHCLSGCPL AERNQSRLKA ELSDSEASAR KKNLSGFSPR KKPRHHGRIG RPPKYRKIPQ EDFQTLTPDV VHQSLFMSAL SAHPDRSLSV CWEQHCKLLP GVAGISASTV AKWTIDEVFG FVQTLTGCED QARLFKDEMI DGEAFLLLTQ ADIVKIMSVK LGPALKIYNA ILMFKNADDT LK
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
92,297 Da
Sequence Positions
1-752, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
608802
3D Structure
ModBase 3D Structure for Q9Y468
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of L3MBTL1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for L3MBTL1 purchase

MBS1428047 is a recombinant protein targeting L3MBTL1. Also known as Recombinant Human Lethal (3)malignant brain tumor-like protein 1 (L3MBTL1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for L3MBTL1. It may not necessarily be applicable to this product.

NCBI GI #
117938328
NCBI GeneID
26013
NCBI Accession #
NP_056293.4
UniProt Primary Accession #
Q9Y468
UniProt Secondary Accession #
Q5H8Y8; Q5H8Y9; Q8IUV7; Q9H1E6; Q9H1G5; Q9UG06; Q9UJB9; Q9Y4C9; B4DRC9; E1P5W7
UniProt Related Accession #
Q9Y468
GenBank Nucleotide #
NM_015478.6
NCBI Official Full Name
lethal(3)malignant brain tumor-like protein 1 isoform I
NCBI Official Synonym Full Names
L3MBTL1, histone methyl-lysine binding protein
NCBI Official Symbol
L3MBTL1
NCBI Official Synonym Symbols
L3MBTL; ZC2HC3; H-L(3)MBT; dJ138B7.3
UniProt Protein Name
Lethal(3)malignant brain tumor-like protein 1
UniProt Synonym Protein Names
L(3)mbt protein homolog; L3MBTL1
Protein Family
Lethal(3)malignant brain tumor-like protein
UniProt Gene Name
L3MBTL1
UniProt Synonym Gene Names
KIAA0681; L3MBT; L3MBTL; H-l(3)mbt; H-l(3)mbt protein; L(3)mbt-like
NCBI Protein Information
lethal(3)malignant brain tumor-like protein 1

NCBI Summary for L3MBTL1

This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
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UniProt Comments for L3MBTL1

Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.
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Research Articles on L3MBTL1

1. Loss of the paternally derived allele of the imprinted L3MBTL1 gene is associated with Shwachman-Diamond syndrome.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with L3MBTL1 recombinant protein

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >3 publications with L3MBTL1 and Brain Diseases
 Adenocarcinoma Antibodies  >1 publications with L3MBTL1 and Adenocarcinoma

Organs/Tissues associated with L3MBTL1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >19 publications with L3MBTL1 and Brain
 Blood Antibodies  >4 publications with L3MBTL1 and Blood
 Bone Antibodies  >3 publications with L3MBTL1 and Bone
 Placenta Antibodies  >1 publications with L3MBTL1 and Placenta
 Embryonic Tissue Antibodies  >1 publications with L3MBTL1 and Embryonic Tissue
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