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Tumor Protein 63 (TP63) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1428406

This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -- mice have several… More details

$1515 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Tumor protein 63 (Tp63), Recombinant Protein
Full Product Name
Recombinant Rat Tumor protein 63 (Tp63)
Product Gene Name
Tp63 recombinant protein
Product Synonym Gene Name
Tp63
Sequence
MNFETSRCAT LQYCPDPYIQ RFIETPSHFS WKESYYRSAM SQSTQTSEFL SPEVFQHIWD FLEQPICSVQ PIDLNFVDEP SENGATNKIE ISMDCIRMQD SDLSDPMWPQ YTNLGLLNGM DQQIQNGSSS TSPYNTDHAQ NSVTAPSPYA QPSSTFDALS PSPAIPSNTD YPGPHSFDVS FQQSSTAKSA TWTYSTELKK LYCQIAKTCP IQIKVMTPPP QGAVIRAMPV YKKAEHVTEV VKRCPNHELS REFNEGQIAP PSHLIRVEGN SHAQYVEDPI TGRQSVLVPY EPPQVGTEFT TVLYNFMCNS SCVGGMNRRP ILIIVTLETR DGQVLGRRCF EARICACPGR DRKADEDSIR KQQVSDSAKN GDGTKRPFRQ NTHGIQMTSI KKRRSPDDEL LYLPVRGRET YEMLLKIKES LELMQYLPQH TIETYRQQQQ QQHQHLLQKQ TSMQSQSSYG NSSPPLNKMN SMNKLPSVSQ LINPQQRNAL TPTTMPEGMG ANIPMMGTHM PMAGDMNGLS PTQALPPPLS MPSTSHCTPP PPYPTDCSIV SFLARLGCSS CLDYFTTQGL TTIYQIEHYS MDDLASLKIP EQFRHAIWKG ILDHRQLHDF SSPPHLLRTP SGASTVSVGS SETRGERVID AVRFTLRQTI SFPPRDEWND FNFDMDSRRN KQQRIKEEGE
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
53,399 Da
Sequence Positions
1-680, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q9JJP6
Species
Rat
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Tp63 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tp63 purchase

MBS1428406 is a recombinant protein targeting Tp63. Also known as Recombinant Rat Tumor protein 63 (Tp63). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Tp63. It may not necessarily be applicable to this product.

NCBI GI #
189083854
NCBI GeneID
246334
NCBI Accession #
NP_001120811.1
UniProt Primary Accession #
Q9JJP6
UniProt Secondary Accession #
Q99JD6; Q99JD7; Q99JD8; Q99JD9; Q99JE0; Q99JE1; Q99JE2; Q99JE3
UniProt Related Accession #
Q9JJP6
GenBank Nucleotide #
NM_001127339.1
NCBI Official Full Name
tumor protein 63 isoform b
NCBI Official Synonym Full Names
tumor protein p63
NCBI Official Symbol
Tp63
NCBI Official Synonym Symbols
Ket; P73l; Tp73l; Trp63
UniProt Protein Name
Tumor protein 63
UniProt Synonym Protein Names
Keratinocyte transcription factor KET; Transformation-related protein 63; TP63; Tumor protein p73-like; p73L
Protein Family
Tumor protein
UniProt Gene Name
Tp63
UniProt Synonym Gene Names
Ket; P63; Tp73l; Trp63; p63; TP63; p73L
NCBI Protein Information
tumor protein 63

NCBI Summary for Tp63

This gene encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73, which have high sequence similarity to one another. This similarity allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways, including direct and indirect protein interactions. This results in mutual regulation of target gene promoters. Both alternative splicing and the use of alternative promoters result in multiple transcript variants encoding different protein isoforms.[provided by RefSeq, Dec 2009]
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UniProt Comments for Tp63

Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates RIPK4 transcription (). Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter ().
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Research Articles on Tp63

1. The pro-survival response of neurons, initiated through the rapid induction of p63, is mediated ultimately by the transcriptional repression of a pro-apoptotic isoform of p73 by ZEB1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Tp63 recombinant protein

 Products by Pathway  Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram

Diseases associated with Tp63 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >486 publications with Tp63 and Neoplasms
 Carcinoma Antibodies  >317 publications with Tp63 and Carcinoma
 Neoplasms, Glandular and Epithelial Antibodies  >270 publications with Tp63 and Neoplasms, Glandular and Epithelial
 Carcinoma, Squamous Cell Antibodies  >181 publications with Tp63 and Carcinoma, Squamous Cell
 Adenocarcinoma Antibodies  >122 publications with Tp63 and Adenocarcinoma
 Skin Abnormalities Antibodies  >84 publications with Tp63 and Skin Abnormalities
 Breast Neoplasms Antibodies  >71 publications with Tp63 and Breast Neoplasms
 Cleft Palate Antibodies  >66 publications with Tp63 and Cleft Palate
 Cleft Lip Antibodies  >65 publications with Tp63 and Cleft Lip
 Female Urogenital Diseases Antibodies  >63 publications with Tp63 and Female Urogenital Diseases

Organs/Tissues associated with Tp63 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >64 publications with Tp63 and Lung
 Eye Antibodies  >64 publications with Tp63 and Eye
 Prostate Antibodies  >58 publications with Tp63 and Prostate
 Embryonic Tissue Antibodies  >42 publications with Tp63 and Embryonic Tissue
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