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Ephexin-1 (NGEF) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1428489

MBS1428489 is a recombinant protein targeting NGEF. Also known as Recombinant Human Ephexin-1 (NGEF). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1555 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Ephexin-1 (NGEF), Recombinant Protein
Full Product Name
Recombinant Human Ephexin-1 (NGEF)
Product Gene Name
NGEF recombinant protein
Product Synonym Gene Name
NGEF
Sequence
METRESEDLE KTRRKSASDQ WNTDNEPAKV KPELLPEKEE TSQADQDIQD KEPHCHIPIK RNSIFNRSIR RKSKAKARDN PERNASCLAD SQDNGKSVNE PLTLNIPWSR MPPCRTAMQT DPGAQEMSES SSTPGNGATP EEWPALADSP TTLTEALRMI HPIPADSWRN LIEQIGLLYQ EYRDKSTLQE IETRRQQDAE IEDNTNGSPA SEDTPEEEEE EEEEEEPASP PERKTLPQIC LLSNPHSRFN LWQDLPEIRS SGVLEILQPE EIKLQEAMFE LVTSEASYYK SLNLLVSHFM ENERIRKILH PSEAHILFSN VLDVLAVSER FLLELEHRME ENIVISDVCD IVYRYAADHF SVYITYVSNQ TYQERTYKQL LQEKAAFREL IAQLELDPKC RGLPFSSFLI LPFQRITRLK LLVQNILKRV EERSERECTA LDAHKELEMV VKACNEGVRK MSRTEQMISI QKKMEFKIKS VPIISHSRWL LKQGELQQMS GPKTSRTLRT KKLFHEIYLF LFNDLLVICR QIPGDKYQVF DSAPRGLLRV EELEDQGQTL ANVFILRLLE NADDREATYM LKASSQSEMK RWMTSLAPNR RTKFVSFTSR LLDCPQVQCV HPYVAQQPDE LTLELADILN ILDKTDDGWI FGERLHDQER GWFPSSMTEE ILNPKIRSQN LKECFRVHKM DDPQRSQNKD RRKLGSRNRQ
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
71,387 Da
Sequence Positions
1-710, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
605991
3D Structure
ModBase 3D Structure for Q8N5V2
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of NGEF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NGEF. It may not necessarily be applicable to this product.

NCBI GI #
166197690
NCBI GeneID
25791
NCBI Accession #
NP_001107562.1
UniProt Primary Accession #
Q8N5V2
UniProt Secondary Accession #
Q53QQ4; Q53ST7; Q6GMQ5; Q9NQD6; B4DMB8; B9A045; E9PC42
UniProt Related Accession #
Q8N5V2
GenBank Nucleotide #
NM_001114090.1
NCBI Official Full Name
ephexin-1 isoform 2
NCBI Official Synonym Full Names
neuronal guanine nucleotide exchange factor
NCBI Official Symbol
NGEF
NCBI Official Synonym Symbols
EPHEXIN; ARHGEF27
UniProt Protein Name
Ephexin-1
UniProt Synonym Protein Names
Eph-interacting exchange protein; Neuronal guanine nucleotide exchange factor
Protein Family
Ephexin
UniProt Gene Name
NGEF
NCBI Protein Information
ephexin-1

UniProt Comments for NGEF

Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension ().
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Research Articles on NGEF

1. A visceral-fat-associated SNP, rs11678490 of NGEF, was found in Korean men.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NGEF recombinant protein

 Reference Product  PubMed Publications
 EPHA4 recombinant protein  >3 publications with NGEF and EPHA4

Pathways associated with NGEF recombinant protein

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 EPHA Forward Signaling Pathway antibodies  EPHA Forward Signaling Pathway Diagram
 G Alpha (12/13) Signalling Events Pathway antibodies  G Alpha (12/13) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 NRAGE Signals Death Through JNK Pathway antibodies  NRAGE Signals Death Through JNK Pathway Diagram
 Regulation Of CDC42 Activity Pathway antibodies  Regulation Of CDC42 Activity Pathway Diagram
 Regulation Of RAC1 Activity Pathway antibodies  Regulation Of RAC1 Activity Pathway Diagram
 Regulation Of RhoA Activity Pathway antibodies  Regulation Of RhoA Activity Pathway Diagram

Diseases associated with NGEF recombinant protein

 Disease Name  Pubmed Publications
 Weight Gain Antibodies  >1 publications with NGEF and Weight Gain
 Brain Neoplasms Antibodies  >1 publications with NGEF and Brain Neoplasms
 Insulin Resistance Antibodies  >1 publications with NGEF and Insulin Resistance
 Neoplasms, Experimental Antibodies  >1 publications with NGEF and Neoplasms, Experimental
 Neoplasms Antibodies  >1 publications with NGEF and Neoplasms

Organs/Tissues associated with NGEF recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >4 publications with NGEF and Eye
 Brain Antibodies  >4 publications with NGEF and Brain
 Nerve Antibodies  >3 publications with NGEF and Nerve
 Muscle Antibodies  >1 publications with NGEF and Muscle
 Kidney Antibodies  >1 publications with NGEF and Kidney
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