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Lysophosphatidylcholine Acyltransferase 2 (LPCAT2) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1428505

This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from… More details

$1105 / 0.5 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Lysophosphatidylcholine acyltransferase 2 (Lpcat2), Recombinant Protein
Full Product Name
Recombinant Mouse Lysophosphatidylcholine acyltransferase 2 (Lpcat2), partial
Product Gene Name
Lpcat2 recombinant protein
Product Synonym Gene Name
Lpcat2
Sequence
MNRCAEAAAV AATVPGSGVG DAGLRPPMVP RQASFFPPPV PNPFVQQTTI SASRRLQM
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
25,486 Da
Sequence Positions
1-58
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q8BYI6
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Lpcat2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Lpcat2 purchase

MBS1428505 is a recombinant protein targeting Lpcat2. Also known as Recombinant Mouse Lysophosphatidylcholine acyltransferase 2 (Lpcat2), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Lpcat2. It may not necessarily be applicable to this product.

NCBI GI #
27370522
NCBI GeneID
270084
NCBI Accession #
NP_766602.1
UniProt Primary Accession #
Q8BYI6
UniProt Secondary Accession #
A3KBM0; A9Q1G2; A9Q1G3
UniProt Related Accession #
Q8BYI6
GenBank Nucleotide #
NM_173014.2
NCBI Official Full Name
lysophosphatidylcholine acyltransferase 2 isoform a
NCBI Official Synonym Full Names
lysophosphatidylcholine acyltransferase 2
NCBI Official Symbol
Lpcat2
NCBI Official Synonym Symbols
Aytl1; Aytl1a; lpafat1; lysoPAFAT; 1-AGPAT 11; A330042H22; lysoPAFAT/LPCAT2
UniProt Protein Name
Lysophosphatidylcholine acyltransferase 2
UniProt Synonym Protein Names
1-acylglycerol-3-phosphate O-acyltransferase 11 (EC:2.3.1.51); 1-AGP acyltransferase 11; 1-AGPAT 11; 1-acylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase (EC:2.3.1.67); Acetyl-CoA:lyso-platelet-activating factor acetyltransferase; Acetyl-CoA:lyso-PAF acetyltransferase; Lyso-PAF acetyltransferase; LysoPAFAT; Acyltransferase-like 1
Protein Family
Lysophosphatidylcholine acyltransferase
UniProt Gene Name
Lpcat2
UniProt Synonym Gene Names
Aytl1; Aytl1a; Lpcat2a; LPC acyltransferase 2; LPCAT-2; LysoPC acyltransferase 2; 1-AGP acyltransferase 11; 1-AGPAT 11; Acetyl-CoA:lyso-PAF acetyltransferase; Lyso-PAF acetyltransferase; LysoPAFAT
NCBI Protein Information
lysophosphatidylcholine acyltransferase 2

UniProt Comments for Lpcat2

Possesses both acyltransferase and acetyltransferase activities (PubMed:17182612, PubMed:18156367). Activity is calcium-dependent (PubMed:17182612). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (PubMed:17182612). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor (PubMed:17182612, PubMed:18156367). Under resting conditions, acyltransferase activity is preferred (PubMed:17182612). Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases (PubMed:17182612). Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3-phosphocholine. Involved in the regulation of lipid droplet number and size ().
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Research Articles on Lpcat2

1. Selected compounds competed with acetyl-CoA for the inhibition of LPCAT2 lyso-PAFAT activity and suppressed PAF biosynthesis in mouse peritoneal macrophages stimulated with a calcium ionophore. These compounds had low inhibitory effects on LPCAT1 activity, indicating that adverse effects on respiratory functions may be avoided.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Lpcat2 recombinant protein

 Reference Product  PubMed Publications
 Lypla1 recombinant protein  >1 publications with Lpcat2 and Lypla1

Pathways associated with Lpcat2 recombinant protein

 Products by Pathway  Pathway Diagram
 Acyl Chain Remodelling Of PC Pathway antibodies  Acyl Chain Remodelling Of PC Pathway Diagram
 Ether Lipid Metabolism Pathway antibodies  Ether Lipid Metabolism Pathway Diagram
 Ether Lipid Metabolism Pathway antibodies  Ether Lipid Metabolism Pathway Diagram
 Glycerophospholipid Biosynthesis Pathway antibodies  Glycerophospholipid Biosynthesis Pathway Diagram
 Glycerophospholipid Metabolism Pathway antibodies  Glycerophospholipid Metabolism Pathway Diagram
 Glycerophospholipid Metabolism Pathway antibodies  Glycerophospholipid Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Phospholipid Metabolism Pathway antibodies  Phospholipid Metabolism Pathway Diagram

Diseases associated with Lpcat2 recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >6 publications with Lpcat2 and Inflammation
 Disease Models, Animal Antibodies  >3 publications with Lpcat2 and Disease Models, Animal
 Liver Diseases Antibodies  >3 publications with Lpcat2 and Liver Diseases
 Fatty Liver Antibodies  >3 publications with Lpcat2 and Fatty Liver
 Liver Cirrhosis Antibodies  >3 publications with Lpcat2 and Liver Cirrhosis
 Non-alcoholic Fatty Liver Disease Antibodies  >2 publications with Lpcat2 and Non-alcoholic Fatty Liver Disease
 Abnormalities, Drug-Induced Antibodies  >1 publications with Lpcat2 and Abnormalities, Drug-Induced
 Lung Diseases Antibodies  >1 publications with Lpcat2 and Lung Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with Lpcat2 and Cell Transformation, Neoplastic
 Fibrosis Antibodies  >1 publications with Lpcat2 and Fibrosis

Organs/Tissues associated with Lpcat2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >5 publications with Lpcat2 and Liver
 Blood Antibodies  >3 publications with Lpcat2 and Blood
 Bone Antibodies  >3 publications with Lpcat2 and Bone
 Bone Marrow Antibodies  >2 publications with Lpcat2 and Bone Marrow
 Prostate Antibodies  >2 publications with Lpcat2 and Prostate
 Spinal Cord Antibodies  >2 publications with Lpcat2 and Spinal Cord
 Lung Antibodies  >1 publications with Lpcat2 and Lung
 Embryonic Tissue Antibodies  >1 publications with Lpcat2 and Embryonic Tissue
 Ovary Antibodies  >1 publications with Lpcat2 and Ovary
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