Human CAPN1 Native Protein – Cat# MBS142918

Calpain-1 Catalytic Subunit (CAPN1) Human Native Protein

Name: CAPN1 Native Protein; Calpain-1 Catalytic Subunit; Human; MyBioSource
Brand: MyBioSource
SKU: MBS142918
Price: 375 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS142918

Description: CAPN1 consists of an 80-kDa large subunit and a 30 kDa small subunit. CAPN1 was purified by sequential chromatography through DEAE-Sepharose, A1.5m Bio-Gel, and Phenyl-Sepharose CL-4B columns. More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Calpain-1 Catalytic Subunit (CAPN1), Native Protein

Full Product Name

Human Calpain-1 Catalytic Subunit

Product Gene Name

CAPN1 native protein

Product Synonym Names

CAPN1; Human Calpain-1 Catalytic Subunit; Calpain-1 catalytic subunit; EC 3.4.22.52; Calpain-1 large subunit; Calcium-activated neutral proteinase 1; Calpain mu-type; muCANP; Micromolar-calpain; Cell proliferation-inducing gene 30 protein; CANP 1; CAPN1; CANPL1; PIG30; CANP; muCL; CANP1

Host

Human Erythrocytes

Form/Format

50mM imidazole-HCl, 100mM NaCl, 5mM EGTA, 1mM DTT and 10% sucrose.
Sterile Filtered colorless solution.

Purity/Purification

Greater than 90% as determined by SDS-PAGE.

Preparation and Storage

CAPN1 although stable at 10 degree C for 1 week, should be stored below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Molecular Weight

81,890 Da

OMIM

114220

3D Structure

ModBase 3D Structure for P07384

Product Categories/Family for CAPN1 native protein

Recombinant & Natural Proteins; Recombinant Proteins; Calpain

Other Notes

Small volumes of CAPN1 native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CAPN1 purchase

MBS142918 is a native protein targeting CAPN1. Also known as Human Calpain-1 Catalytic Subunit. Host: Human Erythrocytes.

Additional Details

NCBI/Uniprot data below describe general gene information for CAPN1. It may not necessarily be applicable to this product.

NCBI GI #

311893363

NCBI GeneID

823

NCBI Accession #

NP_001185797.1

UniProt Primary Accession #

P07384

UniProt Secondary Accession #

Q2TTR0; Q6DHV4

UniProt Related Accession #

P07384

GenBank Nucleotide #

NM_001198868.1

NCBI Official Full Name

calpain-1 catalytic subunit

NCBI Official Synonym Full Names

calpain 1, (mu/I) large subunit

NCBI Official Symbol

CAPN1

NCBI Official Synonym Symbols

CANP; muCL; CANP1; CANPL1; muCANP

UniProt Protein Name

Calpain-1 catalytic subunit

UniProt Synonym Protein Names

Calcium-activated neutral proteinase 1; CANP 1; Calpain mu-type; Calpain-1 large subunit; Cell proliferation-inducing gene 30 protein; Micromolar-calpain; muCANP

Protein Family

Calpain

UniProt Gene Name

CAPN1

UniProt Synonym Gene Names

CANPL1; CANP 1; muCANP

UniProt Entry Name

CAN1_HUMAN

NCBI Protein Information

calpain-1 catalytic subunit; CANP 1; calcium-activated neutral proteinase 1; calpain mu-type; calpain, large polypeptide L1; calpain-1 large subunit; cell proliferation-inducing gene 30 protein; cell proliferation-inducing protein 30; micromolar-calpain

NCBI Summary for CAPN1

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

UniProt Comments for CAPN1

CAPN1: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Forms a heterodimer with a small (regulatory) subunit (CAPNS1). Ubiquitous. Activated by micromolar concentrations of calcium and inhibited by calpastatin. Belongs to the peptidase C2 family.

Protein type: Motility/polarity/chemotaxis; EC 3.4.22.52; Protease

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: focal adhesion; membrane; cytoplasm; plasma membrane; cytosol

Molecular Function: protein binding; calcium-dependent cysteine-type endopeptidase activity; calcium ion binding

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; receptor catabolic process; positive regulation of cell proliferation; proteolysis

Research Articles on CAPN1

1. Besides, calpain-1, a calcium-dependent cysteine protease, was involved inherpes simplex virus type 1 intracellular trafficking.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CAPN1 native protein

Reference Product	PubMed Publications
CAST native protein	>32 publications with CAPN1 and CAST
CAPNS1 native protein	>14 publications with CAPN1 and CAPNS1
PTPN1 native protein	>2 publications with CAPN1 and PTPN1
TP53 native protein	>1 publications with CAPN1 and TP53

Pathways associated with CAPN1 native protein

Products by Pathway	Pathway Diagram
Alzheimer's Disease Pathway antibodies	Alzheimer's Disease Pathway Diagram
Alzheimer's Disease Pathway antibodies	Alzheimer's Disease Pathway Diagram
Alzheimers Disease Pathway antibodies	Alzheimers Disease Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Integrated Pancreatic Cancer Pathway antibodies	Integrated Pancreatic Cancer Pathway Diagram
Integrin-mediated Cell Adhesion Pathway antibodies	Integrin-mediated Cell Adhesion Pathway Diagram

Diseases associated with CAPN1 native protein

Disease Name	Pubmed Publications
Death Antibodies	>23 publications with CAPN1 and Death
Nervous System Diseases Antibodies	>20 publications with CAPN1 and Nervous System Diseases
Heart Diseases Antibodies	>5 publications with CAPN1 and Heart Diseases
Inflammation Antibodies	>5 publications with CAPN1 and Inflammation
Necrosis Antibodies	>5 publications with CAPN1 and Necrosis
Fibrosis Antibodies	>4 publications with CAPN1 and Fibrosis
Nerve Degeneration Antibodies	>4 publications with CAPN1 and Nerve Degeneration
Weight Gain Antibodies	>3 publications with CAPN1 and Weight Gain
Edema Antibodies	>2 publications with CAPN1 and Edema
Breast Neoplasms Antibodies	>2 publications with CAPN1 and Breast Neoplasms

Organs/Tissues associated with CAPN1 native protein

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>48 publications with CAPN1 and Muscle
Blood Antibodies	>19 publications with CAPN1 and Blood
Brain Antibodies	>14 publications with CAPN1 and Brain
Nerve Antibodies	>12 publications with CAPN1 and Nerve
Eye Antibodies	>9 publications with CAPN1 and Eye
Adipose Tissue Antibodies	>8 publications with CAPN1 and Adipose Tissue
Heart Antibodies	>6 publications with CAPN1 and Heart
Connective Tissue Antibodies	>6 publications with CAPN1 and Connective Tissue
Skin Antibodies	>6 publications with CAPN1 and Skin
Embryonic Tissue Antibodies	>6 publications with CAPN1 and Embryonic Tissue