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5'-3' Exoribonuclease 1 (XRN1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1430688

MBS1430688 is a recombinant protein targeting XRN1. Also known as Recombinant Human 5'-3' exoribonuclease 1 (XRN1) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$895 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
5'-3' exoribonuclease 1 (XRN1), Recombinant Protein
Full Product Name
Recombinant Human 5'-3' exoribonuclease 1 (XRN1) , partial
Product Gene Name
XRN1 recombinant protein
Product Synonym Gene Name
XRN1
Sequence
MGVPKFYRWI SERYPCLSEV VKEHQIPEFD NLYLDMNGII HQCSHPNDDD VHFRISDDKI FTDIFHYLEV LFRIIKPRKV FFMAVDGVAP RAKMNQQRGR RFRSAKEAED KIKKAIEKGE TLPTEARFDS NCITPGTEFM ARLHEHLKYF VNMKISTDKS WQGVTIYFSG HETPGEGEHK IMEFIRSEKA KPDHDPNTRH CLYGLDADLI MLGLTSHEAH FSLLREEVRF
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
53,818 Da
Sequence Positions
1-230aa; Partial
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
607994
3D Structure
ModBase 3D Structure for Q8IZH2
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of XRN1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for XRN1. It may not necessarily be applicable to this product.

NCBI GI #
544583596
NCBI GeneID
54464
NCBI Accession #
NP_001269786.1
UniProt Primary Accession #
Q8IZH2
UniProt Secondary Accession #
Q4G0S3; Q68D88; Q6AI24; Q6MZS8; Q86WS7; Q8N8U4; Q9UF39
UniProt Related Accession #
Q8IZH2
GenBank Nucleotide #
NM_001282857.1
NCBI Official Full Name
5'-3' exoribonuclease 1 isoform c
NCBI Official Synonym Full Names
5'-3' exoribonuclease 1
NCBI Official Symbol
XRN1
NCBI Official Synonym Symbols
SEP1
UniProt Protein Name
5'-3' exoribonuclease 1
UniProt Synonym Protein Names
Strand-exchange protein 1 homolog
Protein Family
5'-3' exoribonuclease
UniProt Gene Name
XRN1
UniProt Synonym Gene Names
SEP1
NCBI Protein Information
5'-3' exoribonuclease 1

NCBI Summary for XRN1

This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
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UniProt Comments for XRN1

Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS).
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Research Articles on XRN1

1. Data show that the AR-miR-204-XRN1-miR-34a positive feedback loop and a dual function of miR-204/XRN1 axis in prostate cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with XRN1 recombinant protein

 Reference Product  PubMed Publications
 LSM4 recombinant protein  >2 publications with XRN1 and LSM4
 DCP1B recombinant protein  >1 publications with XRN1 and DCP1B

Pathways associated with XRN1 recombinant protein

 Products by Pathway  Pathway Diagram
 Butyrate Response Factor 1 (BRF1) Destabilizes MRNA Pathway antibodies  Butyrate Response Factor 1 (BRF1) Destabilizes MRNA Pathway Diagram
 Deadenylation-dependent MRNA Decay Pathway antibodies  Deadenylation-dependent MRNA Decay Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 Regulation Of MRNA Stability By Proteins That Bind AU-rich Elements Pathway antibodies  Regulation Of MRNA Stability By Proteins That Bind AU-rich Elements Pathway Diagram
 Ribosome Biogenesis In Eukaryotes Pathway antibodies  Ribosome Biogenesis In Eukaryotes Pathway Diagram
 Ribosome Biogenesis In Eukaryotes Pathway antibodies  Ribosome Biogenesis In Eukaryotes Pathway Diagram
 Tristetraprolin (TTP) Destabilizes MRNA Pathway antibodies  Tristetraprolin (TTP) Destabilizes MRNA Pathway Diagram
 MRNA Decay By 5' To 3' Exoribonuclease Pathway antibodies  MRNA Decay By 5' To 3' Exoribonuclease Pathway Diagram

Diseases associated with XRN1 recombinant protein

 Disease Name  Pubmed Publications
 Hepatitis Antibodies  >7 publications with XRN1 and Hepatitis
 Nervous System Diseases Antibodies  >4 publications with XRN1 and Nervous System Diseases
 Necrosis Antibodies  >4 publications with XRN1 and Necrosis
 Brain Diseases Antibodies  >2 publications with XRN1 and Brain Diseases
 Kidney Diseases Antibodies  >2 publications with XRN1 and Kidney Diseases
 Disease Models, Animal Antibodies  >1 publications with XRN1 and Disease Models, Animal
 Inflammation Antibodies  >1 publications with XRN1 and Inflammation

Organs/Tissues associated with XRN1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with XRN1 and Brain
 Blood Antibodies  >3 publications with XRN1 and Blood
 Kidney Antibodies  >2 publications with XRN1 and Kidney
 Liver Antibodies  >2 publications with XRN1 and Liver
 Testis Antibodies  >2 publications with XRN1 and Testis
 Eye Antibodies  >1 publications with XRN1 and Eye
 Stomach Antibodies  >1 publications with XRN1 and Stomach
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