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Histone-Lysine N-Methyltransferase EZH1 (EZH1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1431027

MBS1431027 is a recombinant protein targeting EZH1. Also known as Recombinant Human Histone-lysine N-methyltransferase EZH1 (EZH1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1610 / 0.02 mg (E-Coli) +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Histone-lysine N-methyltransferase EZH1 (EZH1), Recombinant Protein
Full Product Name
Recombinant Human Histone-lysine N-methyltransferase EZH1 (EZH1)
Product Gene Name
EZH1 recombinant protein
Product Synonym Gene Name
EZH1
Sequence
MEIPNPPTSK CITYWKRKVK SEYMRLRQLK RLQANMGAKA LYVANFAKVQ EKTQILNEEW KKLRVQPVQS MKPVSGHPFL KKCTIESIFP GFASQHMLMR SLNTVALVPI MYSWSPLQQN FMVEDETVLC NIPYMGDEVK EEDETFIEEL INNYDGKVHG EEEMIPGSVL ISDAVFLELV DALNQYSDEE EEGHNDTSDG KQDDSKEDLP VTRKRKRHAI EGNKKSSKKQ FPNDMIFSAI ASMFPENGVP DDMKERYREL TEMSDPNALP PQCTPNIDGP NAKSVQREQS LHSFHTLFCR RCFKYDCFLH PFHATPNVYK RKNKEIKIEP EPCGTDCFLL LEGAKEYAML HNPRSKCSGR RRRRHHIVSA SCSNASASAV AETKEGDSDR DTGNDWASSS SEANSRCQTP TKQKASPAPP QLCVVEAPSE PVEWTGAEES LFRVFHGTYF NNFCSIARLL GTKTCKQVFQ FAVKESLILK LPTDELMNPS QKKKRKHRLW AAHCRKIQLK KDNSSTQVYN YQPCDHPDRP CDSTCPCIMT QNFCEKFCQC NPDCQNRFPG CRCKTQCNTK QCPCYLAVRE CDPDLCLTCG ASEHWDCKVV SCKNCSIQRG LKKHLLLAPS DVAGWGTFIK ESVQKNEFIS EYCGELISQD EADRRGKVYD KYMSSFLFNL NNDFVVDATR KGNKIRFANH SVNPNCYAKV VMVNGDHRIG IFAKRAIQAG EELFFDYRYS QADALKYVGI ERETDVL
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
68,961 Da
Sequence Positions
1-747, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
601674
3D Structure
ModBase 3D Structure for Q92800
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of EZH1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for EZH1. It may not necessarily be applicable to this product.

NCBI GI #
1007353152
NCBI GeneID
2145
NCBI Accession #
NP_001308008.1
UniProt Primary Accession #
Q92800
UniProt Secondary Accession #
O43287; Q14459; Q53XP3; A6NCH6; B4DIJ1; B4DIZ7; B4DSS2; B4E3R7
UniProt Related Accession #
Q92800
GenBank Nucleotide #
NM_001321079.1
NCBI Official Full Name
histone-lysine N-methyltransferase EZH1 isoform 2
NCBI Official Synonym Full Names
enhancer of zeste 1 polycomb repressive complex 2 subunit
NCBI Official Symbol
EZH1
NCBI Official Synonym Symbols
KMT6B
UniProt Protein Name
Histone-lysine N-methyltransferase EZH1
UniProt Synonym Protein Names
ENX-2; Enhancer of zeste homolog 1
Protein Family
Histone-lysine N-methyltransferase
UniProt Gene Name
EZH1
UniProt Synonym Gene Names
KIAA0388
NCBI Protein Information
histone-lysine N-methyltransferase EZH1

NCBI Summary for EZH1

EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]).[supplied by OMIM, Mar 2009]

UniProt Comments for EZH1

Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
Show more

Research Articles on EZH1

1. Data show that embryonic stem cells with deletion of EZH1 or EZH2 fail to differentiate into ectoderm lineages.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with EZH1 recombinant protein

 Reference Product  PubMed Publications
 EZH2 recombinant protein  >67 publications with EZH1 and EZH2
 SUZ12 recombinant protein  >20 publications with EZH1 and SUZ12
 EED recombinant protein  >20 publications with EZH1 and EED
 BMI1 recombinant protein  >2 publications with EZH1 and BMI1
 AEBP2 recombinant protein  >2 publications with EZH1 and AEBP2
 HDAC2 recombinant protein  >1 publications with EZH1 and HDAC2

Pathways associated with EZH1 recombinant protein

 Products by Pathway  Pathway Diagram
 Histone Modifications Pathway antibodies  Histone Modifications Pathway Diagram
 Interactome Of Polycomb Repressive Complex 2 (PRC2) Pathway antibodies  Interactome Of Polycomb Repressive Complex 2 (PRC2) Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram

Diseases associated with EZH1 recombinant protein

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >5 publications with EZH1 and Disease Models, Animal
 Cell Transformation, Neoplastic Antibodies  >5 publications with EZH1 and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >3 publications with EZH1 and Breast Neoplasms
 Inflammation Antibodies  >3 publications with EZH1 and Inflammation
 Kidney Diseases Antibodies  >3 publications with EZH1 and Kidney Diseases
 Hypertrophy Antibodies  >2 publications with EZH1 and Hypertrophy
 Nervous System Diseases Antibodies  >2 publications with EZH1 and Nervous System Diseases
 Fibrosis Antibodies  >2 publications with EZH1 and Fibrosis
 Lung Diseases Antibodies  >1 publications with EZH1 and Lung Diseases
 Liver Diseases Antibodies  >1 publications with EZH1 and Liver Diseases

Organs/Tissues associated with EZH1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >14 publications with EZH1 and Blood
 Bone Antibodies  >8 publications with EZH1 and Bone
 Embryonic Tissue Antibodies  >7 publications with EZH1 and Embryonic Tissue
 Brain Antibodies  >7 publications with EZH1 and Brain
 Kidney Antibodies  >6 publications with EZH1 and Kidney
 Skin Antibodies  >6 publications with EZH1 and Skin
 Liver Antibodies  >5 publications with EZH1 and Liver
 Muscle Antibodies  >5 publications with EZH1 and Muscle
 Heart Antibodies  >4 publications with EZH1 and Heart
 Prostate Antibodies  >4 publications with EZH1 and Prostate
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