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Probable ATP-Dependent RNA Helicase DDX4 (DDX4) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1431784

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and… More details

$1545 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Probable ATP-dependent RNA helicase DDX4 (Ddx4), Recombinant Protein
Full Product Name
Recombinant Mouse Probable ATP-dependent RNA helicase DDX4 (Ddx4)
Product Gene Name
Ddx4 recombinant protein
Product Synonym Gene Name
Ddx4
Sequence
MGDEDWEAEI LKPHVSSYVP VFEKDKYSSG ANGDTFNRTS ASSDIGESSK KENTSTTGGF GRGKGFGNRG FLNNKFEEGD SSGFWKESNN DCEDNQTRSR GFSKRGGCQD GNDSEASGPF RRGGRGSFRG CRGGFGLGRP NSESDQDQGT QRGGGLFGSR KPAASDSGNG DTYQSRSGSG RGGYKGLNEE VVTGSGKNSW KSETEGGESS DSQGPKVTYI PPPPPEDEDS IFAHYQTGIN FDKYDTILVE VSGHDAPPAI LTFEEANLCQ TLNNNIAKAG YTKLTPVQKY SIPIVLAGRD LMACAQTGSG KTAAFLLPIL AHMMRDGITA SRFKELQEPE CIIVAPTREL INQIYLEARK FSFGTCVRAV VIYGGTQFGH SVRQIVQGCN ILCATPGRLM DIIGKEKIGL KQVKYLVLDE ADRMLDMGFG PEMKKLISCP GMPSKEQRQT LLFSATFPEE IQRLAGDFLK SSYLFVAVGQ VGGACRDVQQ TILQVGQYSK REKLVEILRN IGDERTMVFV ETKKKADFIA TFLCQEKIST TSIHGDREQR EREQALGDFR CGKCPVLVAT SVAARGLDIE NVQHVINFDL PSTIDEYVHR IGRTGRCGNT GRAISFFDTD SDNHLAQPLV KVLSDAQQDV PAWLEEIAFS TYVPPSFSSS TRGGAVFASV DTRKNYQGKH TLNTAGISSS QAPNPVDDES WD
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
76,470 Da
Sequence Positions
1-702, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q61496
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Ddx4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ddx4 purchase

MBS1431784 is a recombinant protein targeting Ddx4. Also known as Recombinant Mouse Probable ATP-dependent RNA helicase DDX4 (Ddx4). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Ddx4. It may not necessarily be applicable to this product.

NCBI GI #
33859536
NCBI GeneID
13206
NCBI Accession #
NP_034159.1
UniProt Primary Accession #
Q61496
UniProt Secondary Accession #
Q9D5X7
UniProt Related Accession #
Q61496
GenBank Nucleotide #
NM_010029.2
NCBI Official Full Name
ATP-dependent RNA helicase DDX4 isoform 2
NCBI Official Synonym Full Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
NCBI Official Symbol
Ddx4
NCBI Official Synonym Symbols
Mvh; VASA; AV206478
UniProt Protein Name
ATP-dependent RNA helicase DDX4
UniProt Synonym Protein Names
DEAD box protein 4; Mvh
Protein Family
Probable ATP-dependent RNA helicase
UniProt Gene Name
Ddx4
NCBI Protein Information
ATP-dependent RNA helicase DDX4; probable ATP-dependent RNA helicase DDX4

UniProt Comments for Ddx4

ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity (PubMed:20439430, PubMed:28633017). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:20439430, PubMed:28633017). Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle (PubMed:20439430, PubMed:28633017). Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs (PubMed:28633017).
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Research Articles on Ddx4

1. BHR also decreased the mRNA level of MVH in the bone marrow, and increased mRNA and protein level of MVH in the ovary o fpremature ovarian failure mice

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Ddx4 recombinant protein

 Reference Product  PubMed Publications
 Dazl recombinant protein  >16 publications with Ddx4 and Dazl
 Piwil2 recombinant protein  >6 publications with Ddx4 and Piwil2
 Stra8 recombinant protein  >4 publications with Ddx4 and Stra8
 Tdrd1 recombinant protein  >4 publications with Ddx4 and Tdrd1
 Mael recombinant protein  >3 publications with Ddx4 and Mael
 Nanos1 recombinant protein  >2 publications with Ddx4 and Nanos1
 Piwil4 recombinant protein  >1 publications with Ddx4 and Piwil4

Pathways associated with Ddx4 recombinant protein

 Products by Pathway  Pathway Diagram
 MRNA Processing Pathway antibodies  MRNA Processing Pathway Diagram

Diseases associated with Ddx4 recombinant protein

 Disease Name  Pubmed Publications
 Infertility, Male Antibodies  >9 publications with Ddx4 and Infertility, Male
 Neoplasms Antibodies  >5 publications with Ddx4 and Neoplasms
 Fetal Death Antibodies  >2 publications with Ddx4 and Fetal Death
 Pain Antibodies  >1 publications with Ddx4 and Pain
 Congenital Abnormalities Antibodies  >1 publications with Ddx4 and Congenital Abnormalities
 Infertility, Female Antibodies  >1 publications with Ddx4 and Infertility, Female
 Urogenital Abnormalities Antibodies  >1 publications with Ddx4 and Urogenital Abnormalities

Organs/Tissues associated with Ddx4 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >34 publications with Ddx4 and Testis
 Ovary Antibodies  >16 publications with Ddx4 and Ovary
 Embryonic Tissue Antibodies  >6 publications with Ddx4 and Embryonic Tissue
 Brain Antibodies  >1 publications with Ddx4 and Brain
 Bone Marrow Antibodies  >1 publications with Ddx4 and Bone Marrow
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