Cyclophilin-A (PPIA) Human Active Protein

This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]

PPIA: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Interacts with HIV-1 Capsid protein. Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase. Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.

Protein type: EC 5.2.1.8; Cyclophilin; Isomerase; RNA-binding

Chromosomal Location of Human Ortholog: 7p13

Cellular Component: extracellular space; focal adhesion; membrane; extracellular region; cytosol; nucleus

Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; unfolded protein binding; virion binding; peptide binding

Biological Process: release of virus from host; platelet activation; uncoating of virus; protein peptidyl-prolyl isomerization; positive regulation of viral genome replication; protein folding; viral reproduction; RNA-dependent DNA replication; viral infectious cycle; virus assembly; platelet degranulation; positive regulation of protein secretion; entry into host cell; blood coagulation; leukocyte migration; regulation of viral genome replication