Human BCA 1 Active Protein – Cat# MBS143270

BCA-1/ BLC (BCA 1) Human Active Protein

Name: BCA 1 Active Protein; BCA-1/ BLC; Human; MyBioSource
Brand: MyBioSource
SKU: MBS143270
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143270

Description: CXCL13 Human Recombinant produced in E Coli is a single,non-glycosylated, polypeptide chain containing 87 amino acids and having a molecular mass of 10.3 kDa. The BCA-1 is purified by proprietary chromatographic techniques.Introduction: BCA-1 is… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

BCA-1/ BLC (BCA 1), Active Protein

Full Product Name

Recombinant Human BCA-1/ BLC (CXCL13)

Product Gene Name

BCA 1 active protein

Product Synonym Names

BCA 1 Human; BCA-1/BLC Human Recombinant (CXCL13); C-X-C motif chemokine 13; Small-inducible cytokine B13; B lymphocyte chemoattractant; CXC chemokine BLC; CXCL13; BCA1; BCA-1; CXCL-13; B cell Attracting Chemokine-1; BLC; ANGIE; BLR1L; SCYB13; ANGIE2

Sequence

VLEVYYTSLR CRCVQESSVF IPRRFIDRIQ ILPRGNG CPRKEIIVWK KNKSIVCVDP QAEWIQRMME VLRKR SSSTLPVPVF KRKIP

Host

E Coli

Form/Format

The BCA-1 protein was lyophilized from a concentrated (0.5mg/ml) solution containing 20mM PBS & 150mM NaCl pH-7.4.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Preparation and Storage

Lyophilized BCA1 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution BCA1 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Molecular Weight

12,664 Da

OMIM

605149

3D Structure

ModBase 3D Structure for O43927

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility

It is recommended to reconstitute the lyophilized CXCL13 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Biological Activity

Determined by its ability to chemoattract human B cells using a concentration range of 1-10ng/ml corresponding to a Specific Activity of 100,000-1,000,000IU/mg.

Product Categories/Family for BCA 1 active protein

Chemokines; BCA-1/BLC

Other Notes

Small volumes of BCA 1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BCA 1 purchase

MBS143270 is an active protein targeting BCA 1. Also known as Recombinant Human BCA-1/ BLC (CXCL13). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for BCA 1. It may not necessarily be applicable to this product.

NCBI GI #

5453577

NCBI GeneID

10563

NCBI Accession #

NP_006410.1

UniProt Primary Accession #

O43927

UniProt Related Accession #

O43927

GenBank Nucleotide #

NM_006419.2

NCBI Official Full Name

C-X-C motif chemokine 13

NCBI Official Synonym Full Names

chemokine (C-X-C motif) ligand 13

NCBI Official Symbol

CXCL13

NCBI Official Synonym Symbols

BLC; BCA1; ANGIE; BCA-1; BLR1L; ANGIE2; SCYB13

UniProt Protein Name

C-X-C motif chemokine 13

UniProt Synonym Protein Names

Angie; B cell-attracting chemokine 1; BCA-1; B lymphocyte chemoattractant; CXC chemokine BLC; Small-inducible cytokine B13

UniProt Gene Name

CXCL13

UniProt Synonym Gene Names

BCA1; BLC; SCYB13; BCA-1

UniProt Entry Name

CXL13_HUMAN

NCBI Protein Information

C-X-C motif chemokine 13; B-cell chemoattractant; B-cell-attracting chemokine 1; B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1); B-lymphocyte chemoattractant; CXC chemokine BLC; b cell-attracting chemokine 1; b lymphocyte chemoattractant; chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant); small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant); small-inducible cytokine B13

NCBI Summary for BCA 1

B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Oct 2014]

UniProt Comments for BCA 1

CXCL13: Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B- lymphocytes. Binds to BLR1/CXCR5. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function: heparin binding; fibroblast growth factor binding; CXCR3 chemokine receptor binding; chemokine activity; protein heterodimerization activity; CXCR5 chemokine receptor binding; CCR10 chemokine receptor binding; receptor agonist activity

Biological Process: chronic inflammatory response; lymphocyte chemotaxis across high endothelial venule; response to lipopolysaccharide; positive regulation of integrin activation; lymph node development; regulation of angiogenesis; positive regulation of cell-cell adhesion mediated by integrin; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; cell-cell signaling; regulation of humoral immune response; defense response to bacterium; germinal center formation; immune response; inflammatory response

Research Articles on BCA 1

1. MMP3 and CXCL13 are systemic biomarkers that reflect the aggregate burden of these pathological features across total lung tissue.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BCA 1 active protein

Reference Product	PubMed Publications
CXCR5 active protein	>190 publications with BCA 1 and CXCR5
CCL21 active protein	>122 publications with BCA 1 and CCL21
CCL19 active protein	>99 publications with BCA 1 and CCL19
CCR7 active protein	>51 publications with BCA 1 and CCR7
CXCL9 active protein	>29 publications with BCA 1 and CXCL9
CXCR3 active protein	>28 publications with BCA 1 and CXCR3
CCL20 active protein	>25 publications with BCA 1 and CCL20
CXCL11 active protein	>14 publications with BCA 1 and CXCL11
CCL25 active protein	>12 publications with BCA 1 and CCL25
CXCR1 active protein	>8 publications with BCA 1 and CXCR1

Pathways associated with BCA 1 active protein

Products by Pathway	Pathway Diagram
CXCR3-mediated Signaling Events Pathway antibodies	CXCR3-mediated Signaling Events Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram

Diseases associated with BCA 1 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>154 publications with BCA 1 and Inflammation
Necrosis Antibodies	>58 publications with BCA 1 and Necrosis
Disease Models, Animal Antibodies	>49 publications with BCA 1 and Disease Models, Animal
Lung Diseases Antibodies	>31 publications with BCA 1 and Lung Diseases
Carcinoma Antibodies	>30 publications with BCA 1 and Carcinoma
Kidney Diseases Antibodies	>20 publications with BCA 1 and Kidney Diseases
Hyperplasia Antibodies	>19 publications with BCA 1 and Hyperplasia
Neoplasms, Experimental Antibodies	>18 publications with BCA 1 and Neoplasms, Experimental
Liver Diseases Antibodies	>14 publications with BCA 1 and Liver Diseases
Adenocarcinoma Antibodies	>12 publications with BCA 1 and Adenocarcinoma

Organs/Tissues associated with BCA 1 active protein

Organ/Tissue Name	Pubmed Publications
Lymph Node Antibodies	>179 publications with BCA 1 and Lymph Node
Spleen Antibodies	>80 publications with BCA 1 and Spleen
Vascular Antibodies	>69 publications with BCA 1 and Vascular
Bone Antibodies	>68 publications with BCA 1 and Bone
Lung Antibodies	>44 publications with BCA 1 and Lung
Kidney Antibodies	>24 publications with BCA 1 and Kidney
Intestine Antibodies	>20 publications with BCA 1 and Intestine
Muscle Antibodies	>20 publications with BCA 1 and Muscle
Pharynx Antibodies	>20 publications with BCA 1 and Pharynx
Prostate Antibodies	>19 publications with BCA 1 and Prostate