Mouse mMIP 3alpha Active Protein – Cat# MBS143277

Macrophage Inflammatory Protein-3 Alpha (mMIP 3alpha) Mouse Active Protein

Name: mMIP 3alpha Active Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS143277
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143277

Description: Macrophage Inflammatory Protein-3 alpha Mouse Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 70 amino acids and having a molecular mass of 7.9 kDa. The MIP-3a is purified by proprietary chromatographic… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Macrophage Inflammatory protein-3 alpha (mMIP 3alpha), Active Protein

Full Product Name

Recombinant Mouse Macrophage Inflammatory protein-3 alpha (CCL20)

Product Gene Name

mMIP 3alpha active protein

Product Synonym Names

MIP 3a Mouse; Macrophage Inflammatory Protein-3 alpha Mouse Recombinant (CCL20); mMIP 3a; Small inducible cytokine A20 precursor; CCL20; Macrophage inflammatory protein 3 alpha; MIP-3-alpha; Liver and activation- regulated chemokine; CC chemokine LARC; Beta chemokine exodus-1; CKb4; LARC; ST38; MIP3A; MIP-3a; SCYA20; C-C motif chemokine 20; CC chemokine ST38; exodus-1

Sequence

ASNYDCCLSY IQTPLPSRAI VGFTRQMADE ACDINAIIFH TKKRKSVCAD PKQNWVKRAV NLLSLRVKKM

Host

E Coli

Form/Format

Lyophilized from a concentrated (1mg/ml) solution in water containing no additives.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Preparation and Storage

Lyophilized MIP-3a although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CCL-20 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Molecular Weight

10,755 Da

3D Structure

ModBase 3D Structure for O89093

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility

It is recommended to reconstitute the lyophilized MIP-3a in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Biological Activity

The Activity is calculated by its ability to chemoattract primary human T cells at 2-20ng/ml, corresponding to a specific activity of 50,000-500,000 units/mg.

Product Categories/Family for mMIP 3alpha active protein

Chemokines; MIP

Other Notes

Small volumes of mMIP 3alpha active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for mMIP 3alpha purchase

MBS143277 is an active protein targeting mMIP 3alpha. Also known as Recombinant Mouse Macrophage Inflammatory protein-3 alpha (CCL20). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for mMIP 3alpha. It may not necessarily be applicable to this product.

NCBI GI #

229092240

NCBI GeneID

20297

NCBI Accession #

NP_001153210.1

UniProt Primary Accession #

O89093

UniProt Secondary Accession #

Q9Z1X3

UniProt Related Accession #

O89093

GenBank Nucleotide #

NM_001159738.1

NCBI Official Full Name

C-C motif chemokine 20 isoform 2

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 20

NCBI Official Symbol

Ccl20

NCBI Official Synonym Symbols

CKb4; LARC; ST38; MIP3A; MIP-3A; Scya20; MIP-3[a]; exodus-1

UniProt Protein Name

C-C motif chemokine 20

UniProt Synonym Protein Names

Beta-chemokine exodus-1; CC chemokine LARC; CC chemokine ST38; Liver and activation-regulated chemokine; Macrophage inflammatory protein 3 alpha; MIP-3-alpha; Small-inducible cytokine A20

Protein Family

C-C motif chemokine

UniProt Gene Name

Ccl20

UniProt Synonym Gene Names

Larc; Scya20; MIP-3-alpha

UniProt Entry Name

CCL20_MOUSE

NCBI Protein Information

C-C motif chemokine 20; CC chemokine LARC; CC chemokine ST38; MIP-3-alpha; beta chemokine exodus-1; beta-chemokine exodus-1; liver and activation-regulated chemokine; macrophage inflammatory protein 3 alpha; small inducible cytokine subfamily A20; small-inducible cytokine A20

UniProt Comments for mMIP 3alpha

CCL20: Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli 25922 and S.aureus 29213. Belongs to the intercrine beta (chemokine CC) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide; Chemokine

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; chemokine activity; cytokine activity

Biological Process: immune response; positive regulation of interleukin-1 alpha biosynthetic process; chemotaxis; inflammatory response; positive regulation of nitric-oxide synthase biosynthetic process

Research Articles on mMIP 3alpha

1. Our data indicate that estradiol is important in regulating the effects of keratinocyte growth factor on mouse uterine epithelial cell secretion of CCL20 and CXCL1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with mMIP 3alpha active protein

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
EBV LMP1 Signaling Pathway antibodies	EBV LMP1 Signaling Pathway Diagram

Diseases associated with mMIP 3alpha active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>382 publications with mMIP 3alpha and Inflammation
Necrosis Antibodies	>208 publications with mMIP 3alpha and Necrosis
Skin Diseases Antibodies	>102 publications with mMIP 3alpha and Skin Diseases
Carcinoma Antibodies	>88 publications with mMIP 3alpha and Carcinoma
Lung Diseases Antibodies	>77 publications with mMIP 3alpha and Lung Diseases
Hypersensitivity Antibodies	>57 publications with mMIP 3alpha and Hypersensitivity
Liver Diseases Antibodies	>45 publications with mMIP 3alpha and Liver Diseases
Cardiovascular Diseases Antibodies	>36 publications with mMIP 3alpha and Cardiovascular Diseases
Neoplasms, Experimental Antibodies	>35 publications with mMIP 3alpha and Neoplasms, Experimental
Fibrosis Antibodies	>26 publications with mMIP 3alpha and Fibrosis

Organs/Tissues associated with mMIP 3alpha active protein

Organ/Tissue Name	Pubmed Publications
Thymus Antibodies	>13 publications with mMIP 3alpha and Thymus
Mammary Gland Antibodies	>4 publications with mMIP 3alpha and Mammary Gland
Testis Antibodies	>1 publications with mMIP 3alpha and Testis