Mouse mb NGF Active Protein – Cat# MBS143293

Beta Nerve Growth Factor (mb NGF) Mouse Active Protein

Name: mb NGF Active Protein; Beta Nerve Growth Factor; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS143293
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143293

Description: Recombinant Mouse b-NGF produced in E Coli is a noncovalently disulfide-linked homodimer, non-glycosylated, polypeptide chain containing 2 identical chains of 120 amino acids each and having a molecular mass of 13,471 Dalton each.The Recombinant… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

beta Nerve Growth Factor (mb NGF), Active Protein

Full Product Name

Recombinant Mouse beta Nerve Growth Factor

Product Gene Name

mb NGF active protein

Product Synonym Names

b NGF Mouse; Beta Nerve Growth Factor Mouse Recombinant; Beta Polypeptide; NGF; NGFB; HSAN5; Beta-NGF; MGC161426; MGC161428

Sequence

MSSTHPVFHM GEFSVCDSVS VWVGDKTTAT DIKGKEVTVL AEVNINNSVF RQYFFETKCR ASNPVESGCR GIDSKHWNSY CTTTHTFVKA LTTDEKQAAW RFIRIDTACV CVLSRKATRR G

Host

E Coli

Form/Format

The Recombinant Mouse b-NGF was lyophilized without additives.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 98% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Preparation and Storage

Lyophilized Mouse Beta-NGF although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Murine NGF-Beta should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.Please prevent freeze-thaw cycles.

Molecular Weight

27,077 Da

3D Structure

ModBase 3D Structure for P01139

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility

It is recommended to reconstitute the lyophilized Murine NGF-beta in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Biological Activity

The Mouse b-NGF activity was measured in a cell proliferation assay using a factor-dependent human erythroleukemic cell line, TF-1, the ED50 for this effect is 0.2 ng/ml, corresponding to a Specific Activity of 5,000,000 units/mg.

Product Categories/Family for mb NGF active protein

Cytokines and Growth Factors; Neurotrophins; Beta-Nerve Growth Factor

Other Notes

Small volumes of mb NGF active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for mb NGF purchase

MBS143293 is an active protein targeting mb NGF. Also known as Recombinant Mouse beta Nerve Growth Factor. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for mb NGF. It may not necessarily be applicable to this product.

NCBI GI #

162951831

NCBI GeneID

18049

NCBI Accession #

NP_001106168.1

UniProt Primary Accession #

P01139

UniProt Secondary Accession #

Q63864; Q6LDB7

UniProt Related Accession #

P01139

GenBank Nucleotide #

NM_001112698.2

NCBI Official Full Name

beta-nerve growth factor isoform B

NCBI Official Synonym Full Names

nerve growth factor

NCBI Official Symbol

Ngf

NCBI Official Synonym Symbols

Ngfb

UniProt Protein Name

Beta-nerve growth factor

Protein Family

Beta-nerve growth factor

UniProt Gene Name

Ngf

UniProt Synonym Gene Names

Ngfb; Beta-NGF

UniProt Entry Name

NGF_MOUSE

NCBI Protein Information

beta-nerve growth factor; beta-NGF; nerve growth factor, beta

UniProt Comments for mb NGF

NGF: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Homodimer. Belongs to the NGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular space; cytoplasmic membrane-bound vesicle; extracellular region

Molecular Function: metalloendopeptidase inhibitor activity; nerve growth factor receptor binding; growth factor activity; receptor signaling protein activity; receptor binding

Biological Process: positive regulation of neuron maturation; adult locomotory behavior; regulation of neuron differentiation; positive regulation of axon extension; regulation of neurotransmitter secretion; sensory perception of pain; positive regulation of cell growth; positive regulation of protein amino acid autophosphorylation; regulation of release of sequestered calcium ion into cytosol; memory; positive regulation of nerve growth factor receptor signaling pathway; peripheral nervous system development; neuron apoptosis; induction of apoptosis via death domain receptors; positive regulation of cell proliferation; positive regulation of transcription factor activity; negative regulation of neuron apoptosis; positive regulation of neuron differentiation; positive regulation of collateral sprouting; transmembrane receptor protein tyrosine kinase signaling pathway; neurite development; neurite morphogenesis

Research Articles on mb NGF

1. NGF facilitates depolarization-induced NFAT activation by stimulating PI3K/Akt signaling, inactivating GSK3beta, and thereby slowing NFATc3 export from the nucleus

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with mb NGF active protein

Products by Pathway	Pathway Diagram
ARMS-mediated Activation Pathway antibodies	ARMS-mediated Activation Pathway Diagram
Activation Of TRKA Receptors Pathway antibodies	Activation Of TRKA Receptors Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptosis Signaling Pathway antibodies	Apoptosis Signaling Pathway Diagram
Axonal Growth Stimulation Pathway antibodies	Axonal Growth Stimulation Pathway Diagram
Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies	Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
Ceramide Signalling Pathway antibodies	Ceramide Signalling Pathway Diagram
Frs2-mediated Activation Pathway antibodies	Frs2-mediated Activation Pathway Diagram
Id Signaling Pathway antibodies	Id Signaling Pathway Diagram

Diseases associated with mb NGF active protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>2217 publications with mb NGF and Nervous System Diseases
Pain Antibodies	>764 publications with mb NGF and Pain
Neurodegenerative Diseases Antibodies	>736 publications with mb NGF and Neurodegenerative Diseases
Inflammation Antibodies	>699 publications with mb NGF and Inflammation
Nerve Degeneration Antibodies	>612 publications with mb NGF and Nerve Degeneration
Peripheral Nervous System Diseases Antibodies	>466 publications with mb NGF and Peripheral Nervous System Diseases
Necrosis Antibodies	>447 publications with mb NGF and Necrosis
Hyperalgesia Antibodies	>318 publications with mb NGF and Hyperalgesia
Heart Diseases Antibodies	>126 publications with mb NGF and Heart Diseases
Memory Disorders Antibodies	>113 publications with mb NGF and Memory Disorders

Organs/Tissues associated with mb NGF active protein

Organ/Tissue Name	Pubmed Publications
Salivary Gland Antibodies	>269 publications with mb NGF and Salivary Gland
Lung Antibodies	>175 publications with mb NGF and Lung
Kidney Antibodies	>161 publications with mb NGF and Kidney
Bone Marrow Antibodies	>154 publications with mb NGF and Bone Marrow
Connective Tissue Antibodies	>112 publications with mb NGF and Connective Tissue
Thyroid Antibodies	>93 publications with mb NGF and Thyroid
Testis Antibodies	>67 publications with mb NGF and Testis
Uncharacterized Tissue Antibodies	>1 publications with mb NGF and Uncharacterized Tissue