Rabbit raGHBP Active Protein – Cat# MBS143305

Growth Hormone (raGHBP) Rabbit Active Protein

Name: raGHBP Active Protein; Growth Hormone; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS143305
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143305

Description: Growth Hormone Binding Protein Rabbit Extracellular Domain Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 249 amino acids and having a molecular mass of 28 kDa. GHBP Rabbit is purified by proprietary… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Growth Hormone (raGHBP), Active Protein

Full Product Name

Recombinant Rabbit Growth Hormone Binding Protein

Product Gene Name

raGHBP active protein

Product Synonym Names

GHBP Rabbit; Growth Hormone Binding Protein Rabbit Recombinant; GHR; GHBP; GH receptor; Somatotropin receptor

Sequence

AFSGSEATPA TLGRASESVQ RVHPGLGTNS SGKPKFTKCR SPELETFSCH WTDGVHHGLK SPGSVQLFYI RRNTQEWTQE WKECPDYVSA GENSCYFNSS YTSIWIPYCI KLTNNGGMVD QKCFSVEEIV QPDPPIGLNW TLLNVSLTGI HADIQVRWEP PPNADVQKGW IVLEYELQYK EVNETQWKMM DPVLSTSVPV YSLRLDKEYE VRVRSRQRSS EKYGEFSEVL YVTLPQMSPF TCEEDFRFP

Form/Format

The Growth Hormone Binding Protein Rabbit was lyophilized from a concentrated (1mg/ml) solution with 0.0045mM NaHCO3.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 98.0% as determined bySDS-PAGE.

Preparation and Storage

Lyophilized Growth Hormone Binding Protein Rabbit although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution GHBP Rabbit should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

3D Structure

ModBase 3D Structure for P19941

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Source

Escherichia Coli.

Solubility

It is recommended to reconstitute the lyophilized GHBP Rabbit in sterile 0.4% NaHCO3 pH 10, not less than 100ug/ml, which can then be further diluted to other aqueous solutions.

Biological Activity

Evidended by its ability of forming 2:1 complex with non-primate Growth Hormones.

Product Categories/Family for raGHBP active protein

Cytokines and Growth Factors; Growth Factors; Growth Hormone

Other Notes

Small volumes of raGHBP active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for raGHBP purchase

MBS143305 is an active protein targeting raGHBP. Also known as Recombinant Rabbit Growth Hormone Binding Protein.

Additional Details

NCBI/Uniprot data below describe general gene information for raGHBP. It may not necessarily be applicable to this product.

NCBI GI #

130492708

NCBI GeneID

100009325

NCBI Accession #

NP_001076105.1

UniProt Primary Accession #

P19941

UniProt Related Accession #

P19941

GenBank Nucleotide #

NM_001082636.1

NCBI Official Full Name

growth hormone receptor

NCBI Official Symbol

GHR

UniProt Protein Name

Growth hormone receptor

UniProt Synonym Protein Names

Somatotropin receptorGrowth hormone-binding protein; GH-binding protein; GHBPAlternative name(s):Serum-binding protein

Protein Family

Growth hormone

UniProt Gene Name

GHR

UniProt Synonym Gene Names

GH receptor; GH-binding protein; GHBP

UniProt Entry Name

GHR_RABIT

NCBI Protein Information

growth hormone receptor; GH receptor; somatotropin receptor

UniProt Comments for raGHBP

GH receptor: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. Defects in GHR are a cause of Laron syndrome (LARS). A severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Defects in GHR may be a cause of idiopathic short stature autosomal (ISSA). Short stature is defined by a subnormal rate of growth. Belongs to the type I cytokine receptor family. Type 1 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Research Articles on raGHBP

1. Jak2 binding to the growth hormone receptor prevents endocytosis in a non-catalytic manner

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with raGHBP active protein

Reference Product	PubMed Publications
JAK2 active protein	>175 publications with raGHBP and JAK2
STAT5B active protein	>62 publications with raGHBP and STAT5B
PRL active protein	>52 publications with raGHBP and PRL
SOCS3 active protein	>21 publications with raGHBP and SOCS3
GH1 active protein	>21 publications with raGHBP and GH1
SOCS2 active protein	>16 publications with raGHBP and SOCS2
JAK1 active protein	>5 publications with raGHBP and JAK1
INS active protein	>5 publications with raGHBP and INS
TYK2 active protein	>4 publications with raGHBP and TYK2

Pathways associated with raGHBP active protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram

Diseases associated with raGHBP active protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>86 publications with raGHBP and Nervous System Diseases
Laron Syndrome Antibodies	>81 publications with raGHBP and Laron Syndrome
Disease Models, Animal Antibodies	>66 publications with raGHBP and Disease Models, Animal
Weight Gain Antibodies	>51 publications with raGHBP and Weight Gain
Liver Diseases Antibodies	>50 publications with raGHBP and Liver Diseases
Carcinoma Antibodies	>49 publications with raGHBP and Carcinoma
Necrosis Antibodies	>35 publications with raGHBP and Necrosis
Kidney Diseases Antibodies	>35 publications with raGHBP and Kidney Diseases
Inflammation Antibodies	>29 publications with raGHBP and Inflammation
Fatty Liver Antibodies	>25 publications with raGHBP and Fatty Liver

Organs/Tissues associated with raGHBP active protein

Organ/Tissue Name	Pubmed Publications
Eye Antibodies	>17 publications with raGHBP and Eye