Human IL 28A Recombinant Protein – Cat# MBS143321

Interleukin-28a (IL 28A) Human Recombinant Protein

Name: IL 28A Recombinant Protein; Interleukin-28a; Human; MyBioSource
Brand: MyBioSource
SKU: MBS143321
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143321

Description: IL-28A human recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 175 amino acids and having a molecular mass of 19.6 kDa.Introduction: IL-28A is distantly related to type I interferons and the IL-10 family.… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Interleukin-28A (IL 28A), Recombinant Protein

Full Product Name

Recombinant Human Interleukin-28A

Product Gene Name

IL 28A recombinant protein

Product Synonym Names

IL 28A Human; Interleukin-28A Human Recombinant; Interleukin-28A; IL-28A; IFN-Lambda 2; Interferon-Lambda 2; Cytokine ZCYTO20; IL28A; IFNL2; ZCYTO20

Sequence

VPVAR LHGALPDARG CHIAQFKSLS PQELQAFKRA KDALEESLLL KDCRCHSRLF PRTWDLRQLQ VRERPMALEA ELALTLKVLE ATADTDPALV DVLDQPLHTL HHILSQFRAC IQPQPTAGPR TRGRLHHWLY RLQEAPKKES PGCLEASVTF NLFRLLTRDL NCVASGDLCV

Host

E Coli

Form/Format

Lyophilized from a 0.2 um filtered solution containing no additives.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 85% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Preparation and Storage

Lyophilized IFN-Lambda 2 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IFN-Lambda 2 Recombinant should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Molecular Weight

22,288 Da

OMIM

607401

3D Structure

ModBase 3D Structure for Q8IZJ0

Solubility

It is recommended to reconstitute the lyophilized IL-28A in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Product Categories/Family for IL 28A recombinant protein

Cytokines and Growth Factors; Cytokines; Interleukin

Other Notes

Small volumes of IL 28A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL 28A purchase

MBS143321 is a recombinant protein targeting IL 28A. Also known as Recombinant Human Interleukin-28A. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL 28A. It may not necessarily be applicable to this product.

NCBI GI #

26024321

NCBI GeneID

282616

NCBI Accession #

NP_742150.1

UniProt Primary Accession #

Q8IZJ0

UniProt Secondary Accession #

Q45KQ8; Q6VN55; Q8IWL7

UniProt Related Accession #

Q8IZJ0

GenBank Nucleotide #

NM_172138.1

NCBI Official Full Name

interferon lambda-2

NCBI Official Synonym Full Names

interferon, lambda 2

NCBI Official Symbol

IFNL2

NCBI Official Synonym Symbols

IL28A; IL-28A

UniProt Protein Name

Interferon lambda-2

UniProt Synonym Protein Names

Cytokine Zcyto20; Interleukin-28A; IL-28A

Protein Family

Interferon

UniProt Gene Name

IFNL2

UniProt Synonym Gene Names

IL28A; ZCYTO20; IFN-lambda-2; IL-28A

UniProt Entry Name

IFNL2_HUMAN

NCBI Protein Information

interferon lambda-2; IFN-lambda-2; cytokine Zcyto20; interferon lambda 2; interferon-lambda 2; interleukin 28A (interferon, lambda 2); interleukin-28A

NCBI Summary for IL 28A

This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

UniProt Comments for IL 28A

IL28A: Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the IL-28/IL-29 family.

Protein type: Cytokine; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19q13.13

Cellular Component: extracellular space

Molecular Function: cytokine activity

Biological Process: positive regulation of immune response; mucosal immune response; JAK-STAT cascade; defense response to virus

Research Articles on IL 28A

1. Results showed no association between genotypes and alleles of IL28A, IL28B or IL29 polymorphisms and Hepatitis C virus infection.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with IL 28A recombinant protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Type III Interferon Signaling Pathway antibodies	Type III Interferon Signaling Pathway Diagram