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Heat Shock Protein 105 (HSP105) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143382

Description: Recombinant HSPH1 produced in E Coli is a single, non-glycosylated polypeptide chain containing 894 amino acids and having a molecular mass of 100.9kDa. HSP105 Alpha is fused with a 36 a.a. His tag and purified by conventional chromatography… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Heat Shock Protein 105 (HSP105), Recombinant Protein
Full Product Name
Recombinant Human Heat Shock Protein 105
Product Gene Name
HSP105 recombinant protein
Product Synonym Names
HSPH1 Human; Heat Shock Protein 105 Human Recombinant; HSPH1; Heat Shock protein 105kDa; 110kDa protein 1; Heat shock 110 kDa protein; HSP110; HSP105A; Antigen NY-CO-25; HSP105; HSP105A; HSP105B; KIAA0201; NY-CO-25; DKFZp686M05240
Sequence
MRGSHHH HHH GMASMTGGQQ MGRDLYDDDD KDRWGS MSVV GLDVGSQSCY IAVARAGGIE TIANEFSDRC TPSVISFGSK NRTIGVAAKN QQITHANNTV SNFKRFHGRA FNDPFIQKEK ENLSYDLVPL KNGGVGIKVM YMGEEHLFSV EQITAMLLTK LKETAENSLK KPVTDCVISV PSFFTDAERR SVLDAAQIVG LNCLRLMNDM TAVALNYGIY KQDLPSLDEK PRIVVFVDMG HSAFQVSACA FNKGKLKVLG TAFDPFLGGK NFDEKLVEHF CAEFKTKYKL DAKSKIRALL RLYQECEKLK KLMSSNSTDL PLNIECFMND KDVSGKMNRS QFEELCAELL QKIEVPLYSL LEQTHLKVED VSAVEIVGGA TRIPAVKERI AKFFGKDIST TLNADEAVAR GCALQCAILS PAFKVREFSV TDAVPFPISL IWNHDSEDTE GVHEVFSRNH AAPFSKVLTF LRRGPFELEA FYSDPQGVPY PEAKIGRFVV QNVSAQKDGE KSRVKVKVRV NTHGIFTIST ASMVEKVPTE ENEMSSEADM ECLNQRPPEN PDTDKNVQQD NSEAGTQPQV QTDAQQTSQS PPSPELTSEE NKIPDADKAN EKKVDQPPEA KKPKIKVVNV ELPIEANLVW QLGKDLLNMY IETEGKMIMQ DKLEKERNDA KNAVEEYVYE FRDKLCGPYE KFICEQDHQN FLRLLTETED WLYEEGEDQA KQAYVDKLEE LMKIGTPVKV RFQEAEERPK MFEELGQRLQ HYAKIAADFR NKDEKYNHID ESEMKKVEKS VNEVMEWMNN VMNAQAKKSL DQDPVVRAQE IKTKIKELNN TCEPVVTQPK PKIESPKLER TPNGPNIDKK EEDLEDKNNF GAEPPHQNGE CYPNEKNSVN MDLD
Host
E Coli
Form/Format
The HSP105 protein solution contains 20mM Tris-HCl, pH-8 and 50mM NaCl.
Sterile filtered colorless solution.
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
OMIM
610703
3D Structure
ModBase 3D Structure for Q92598

Product Categories/Family for HSP105 recombinant protein

Heat Shock Proteins; Recombinant Proteins; Heat Shock Protein

Other Notes

Small volumes of HSP105 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HSP105 purchase

MBS143382 is a recombinant protein targeting HSP105. Also known as Recombinant Human Heat Shock Protein 105. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for HSP105. It may not necessarily be applicable to this product.

NCBI GI #
557357685
NCBI GeneID
10808
NCBI Accession #
NP_001273432.1
UniProt Primary Accession #
Q92598
UniProt Secondary Accession #
O95739; Q5TBM6; Q5TBM7; Q5TBM8; Q9UPC4; B4DYH1
UniProt Related Accession #
Q92598
GenBank Nucleotide #
NM_001286503.1
NCBI Official Full Name
heat shock protein 105 kDa isoform 2
NCBI Official Synonym Full Names
heat shock 105kDa/110kDa protein 1
NCBI Official Symbol
HSPH1
NCBI Official Synonym Symbols
HSP105; HSP105A; HSP105B; NY-CO-25
UniProt Protein Name
Heat shock protein 105 kDa
UniProt Synonym Protein Names
Antigen NY-CO-25; Heat shock 110 kDa protein
Protein Family
Heat shock protein
UniProt Gene Name
HSPH1
UniProt Synonym Gene Names
HSP105; HSP110; KIAA0201
UniProt Entry Name
HS105_HUMAN
NCBI Protein Information
heat shock protein 105 kDa; antigen NY-CO-25; heat shock 105kD alpha; heat shock 105kD beta

UniProt Comments for HSP105

HSP105: a molecular chaperone of the heat shock protein 70 family. Has ATPase activity. Expressed at especially high levels in mammalian brain and has been shown to suppress apoptosis in neuronal cells and to prevent the aggregation of proteins following heat shock. Known to interact with a variety of proteins including alpha-tubulin and the androgen receptor. Two alternatively spliced isoforms have been described.

Protein type: Heat shock protein; Chaperone

Chromosomal Location of Human Ortholog: 13q12.3

Cellular Component: nucleoplasm; microtubule; cytoplasm; extracellular region; cytosol

Molecular Function: protein binding; alpha-tubulin binding; ATP binding

Biological Process: receptor-mediated endocytosis; positive regulation of NK T cell activation; chaperone cofactor-dependent protein folding; positive regulation of MHC class I biosynthetic process; response to unfolded protein
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Research Articles on HSP105

1. A receiver operating characteristic curve constructed with HSP105 and TIM gave a sensitivity of 54.3% and 95% (38/40) specificity in discriminating esophageal squamous cell carcinoma from matched controls.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with HSP105 recombinant protein

 Reference Product  PubMed Publications
 DNAJB1 recombinant protein  >8 publications with HSP105 and DNAJB1
 DNAJA1 recombinant protein  >5 publications with HSP105 and DNAJA1
 HSPA8 recombinant protein  >4 publications with HSP105 and HSPA8
 HSP90AA1 recombinant protein  >1 publications with HSP105 and HSP90AA1

Pathways associated with HSP105 recombinant protein

 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Scavenging By Class F Receptors Pathway antibodies  Scavenging By Class F Receptors Pathway Diagram

Diseases associated with HSP105 recombinant protein

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >6 publications with HSP105 and Adenocarcinoma
 Disease Models, Animal Antibodies  >3 publications with HSP105 and Disease Models, Animal
 Inflammation Antibodies  >3 publications with HSP105 and Inflammation
 Cardiovascular Diseases Antibodies  >3 publications with HSP105 and Cardiovascular Diseases
 Heart Diseases Antibodies  >2 publications with HSP105 and Heart Diseases
 Pancreatic Neoplasms Antibodies  >2 publications with HSP105 and Pancreatic Neoplasms
 Necrosis Antibodies  >2 publications with HSP105 and Necrosis
 Cell Transformation, Neoplastic Antibodies  >1 publications with HSP105 and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >1 publications with HSP105 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >1 publications with HSP105 and Lung Neoplasms

Organs/Tissues associated with HSP105 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with HSP105 and Blood
 Skin Antibodies  >7 publications with HSP105 and Skin
 Brain Antibodies  >7 publications with HSP105 and Brain
 Lymph Node Antibodies  >3 publications with HSP105 and Lymph Node
 Lymph Antibodies  >3 publications with HSP105 and Lymph
 Testis Antibodies  >3 publications with HSP105 and Testis
 Liver Antibodies  >2 publications with HSP105 and Liver
 Intestine Antibodies  >2 publications with HSP105 and Intestine
 Lung Antibodies  >2 publications with HSP105 and Lung
 Vascular Antibodies  >2 publications with HSP105 and Vascular
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