Calcium and Integrin Binding 1 (CIB1) Human Recombinant Protein

This gene encodes a member of the EF-hand domain-containing calcium-binding superfamily. The encoded protein interacts with many other proteins, including the platelet integrin alpha-IIb-beta-3, DNA-dependent protein kinase, presenilin-2, focal adhesion kinase, p21 activated kinase, and protein kinase D. The encoded protein may be involved in cell survival and proliferation, and is associated with several disease states including cancer and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

CIB1: May convert the inactive conformation of integrin alpha- IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2/FAK1 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Participates in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation.

Protein type: Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 15q25.3-q26

Cellular Component: Golgi apparatus; filopodium tip; centrosome; neuron projection; endoplasmic reticulum; nucleoplasm; growth cone; membrane; cell soma; perinuclear region of cytoplasm; lamellipodium; cytoplasm; apical plasma membrane; plasma membrane; nucleus; sarcolemma; vesicle

Molecular Function: protein binding; Ras GTPase binding; protein anchor; calcium ion binding

Biological Process: apoptosis; endomitotic cell cycle; cytoplasmic microtubule organization and biogenesis; negative regulation of megakaryocyte differentiation; activation of NF-kappaB transcription factor; negative regulation of cell proliferation; negative regulation of protein amino acid phosphorylation; double-strand break repair; positive regulation of cell proliferation; angiogenesis; cell adhesion; positive regulation of cell-matrix adhesion; negative regulation of protein kinase B signaling cascade; negative regulation of microtubule depolymerization; positive regulation of cell adhesion mediated by integrin; positive regulation of metalloenzyme activity; positive regulation of cell growth; regulation of cell proliferation; cell division; positive regulation of protein amino acid phosphorylation; platelet formation; response to DNA damage stimulus; regulation of cell division; spermatid development; positive regulation of cell migration; negative regulation of apoptosis