Bovine baFGF Active Protein – Cat# MBS143477

Fibroblast Growth Factor-Acidic (baFGF) Bovine Active Protein

Name: baFGF Active Protein; Fibroblast Growth Factor-Acidic; Bovine; MyBioSource
Brand: MyBioSource
SKU: MBS143477
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143477

Description: Fibroblast Growth Factor-acidic Bovine (FGF-1) purified from Bovine Brain contains a 17 kDa and a 20 kDa polypeptide chain. The 17 kDa peptide is derived from the 20K peptide by restricted proteolysis. (See Jaye et al ). The FGF acidic is… More details

DISCONTINUED

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Fibroblast Growth Factor-acidic (baFGF), Active Protein

Full Product Name

Bovine Fibroblast Growth Factor-acidic

Product Gene Name

baFGF active protein

Product Synonym Names

aFGF Bovine; Fibroblast Growth Factor Acidic Bovine; HBGF-1; ECGF-beta; FIBP; FGFIBP; FIBP-1; ECGF; ECGFA; GLIO703; FGF1; FGF-a

Host

Bovine Brain

Form/Format

Each 5 ug aFGF were lyophilized from 0.5ml solution containing 1mM sodium phosphate, pH 7 after filtration over a low binding membrane.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 90%.

Preparation and Storage

Lyophilized aFGF although stable at room temperature for 2 weeks, should be stored desiccated below -18 degree C. Upon reconstitution aFGF should be stored at 4 degree C between 2-3 weeks and for future use below -18 degree C.Please prevent freeze-thaw cycles.

Molecular Weight

17,493 Da

3D Structure

ModBase 3D Structure for P03968

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility

It is recommended to reconstitute the lyophilized aFGF in sterile 50mM Na2HPO4 pH-7, and 0.5% albumin. The Recommended concentration in cell culture: 1-20ng/ml.

Biological Activity

Stimulates growth of bovine capillary endothelial cells by 3-5 fold over 5% calf serum at 10-25ng/ml FGF and 0ug/ml heparin.

Product Categories/Family for baFGF active protein

Cytokines and Growth Factors; Growth Factors; Fibroblast Growth Factor

Other Notes

Small volumes of baFGF active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for baFGF purchase

MBS143477 is an active protein targeting baFGF. Also known as Bovine Fibroblast Growth Factor-acidic. Host: Bovine Brain.

Additional Details

NCBI/Uniprot data below describe general gene information for baFGF. It may not necessarily be applicable to this product.

NCBI GI #

27806633

NCBI GeneID

281160

NCBI Accession #

NP_776480.1

UniProt Primary Accession #

P03968

UniProt Secondary Accession #

Q3ZBL8

UniProt Related Accession #

P03968

GenBank Nucleotide #

NM_174055.2

NCBI Official Full Name

fibroblast growth factor 1

NCBI Official Synonym Full Names

fibroblast growth factor 1 (acidic)

NCBI Official Symbol

FGF1

NCBI Official Synonym Symbols

ECGF; FGF-1

UniProt Protein Name

Fibroblast growth factor 1

UniProt Synonym Protein Names

Acidic eye-derived growth factor II; EDGF II; Acidic fibroblast growth factor; aFGF; Endothelial cell growth factor; ECGF; Heparin-binding growth factor 1; HBGF-1; ProstatropinCleaved into the following 2 chains:Endothelial cell growth factor beta; Endothelial cell growth factor alpha

UniProt Gene Name

FGF1

UniProt Synonym Gene Names

AFGF; FGFA; HBGF-1; FGF-1; EDGF II; aFGF; ECGF; HBGF-1

UniProt Entry Name

FGF1_BOVIN

NCBI Protein Information

fibroblast growth factor 1; EDGF II; HBGF-1; aFGF; acidic eye-derived growth factor II; acidic fibroblast growth factor; endothelial cell growth factor beta and alpha chains; endothelial growth factor; fibroblast growth factor, acidic; heparin-binding growth factor 1; prostatropin

UniProt Comments for baFGF

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis ().

Research Articles on baFGF

1. FGF1 and FGF7 may be involved differently in the process of follicle maturation and CL formation, which is strongly dependent on angiogenesis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with baFGF active protein

Reference Product	PubMed Publications
FGFR1 active protein	>221 publications with baFGF and FGFR1
FGFR2 active protein	>123 publications with baFGF and FGFR2
FGFR3 active protein	>67 publications with baFGF and FGFR3
FGFR4 active protein	>56 publications with baFGF and FGFR4
Fgf8 active protein	>29 publications with baFGF and Fgf8
FGF5 active protein	>21 publications with baFGF and FGF5
MET active protein	>20 publications with baFGF and MET
EGFR active protein	>14 publications with baFGF and EGFR
IGF1R active protein	>2 publications with baFGF and IGF1R

Pathways associated with baFGF active protein

Products by Pathway	Pathway Diagram
Activated Point Mutants Of FGFR2 Pathway antibodies	Activated Point Mutants Of FGFR2 Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies	Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
DAP12 Interactions Pathway antibodies	DAP12 Interactions Pathway Diagram
DAP12 Signaling Pathway antibodies	DAP12 Signaling Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Downstream Signal Transduction Pathway antibodies	Downstream Signal Transduction Pathway Diagram
Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies	Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
Downstream Signaling Of Activated FGFR Pathway antibodies	Downstream Signaling Of Activated FGFR Pathway Diagram
FGFR Ligand Binding And Activation Pathway antibodies	FGFR Ligand Binding And Activation Pathway Diagram

Diseases associated with baFGF active protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>137 publications with baFGF and Nervous System Diseases
Heart Diseases Antibodies	>63 publications with baFGF and Heart Diseases
Inflammation Antibodies	>60 publications with baFGF and Inflammation
Necrosis Antibodies	>59 publications with baFGF and Necrosis
Myocardial Ischemia Antibodies	>55 publications with baFGF and Myocardial Ischemia
Neoplasms, Experimental Antibodies	>43 publications with baFGF and Neoplasms, Experimental
Hyperplasia Antibodies	>39 publications with baFGF and Hyperplasia
Fibrosis Antibodies	>35 publications with baFGF and Fibrosis
Cell Transformation, Neoplastic Antibodies	>33 publications with baFGF and Cell Transformation, Neoplastic
Liver Diseases Antibodies	>33 publications with baFGF and Liver Diseases

Organs/Tissues associated with baFGF active protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>300 publications with baFGF and Brain
Muscle Antibodies	>249 publications with baFGF and Muscle
Embryonic Tissue Antibodies	>169 publications with baFGF and Embryonic Tissue
Kidney Antibodies	>83 publications with baFGF and Kidney
Intestine Antibodies	>40 publications with baFGF and Intestine
Adipose Tissue Antibodies	>31 publications with baFGF and Adipose Tissue
Uterus Antibodies	>16 publications with baFGF and Uterus
Extraembryonic Tissue Antibodies	>2 publications with baFGF and Extraembryonic Tissue
Pineal Gland Antibodies	>1 publications with baFGF and Pineal Gland