Human ACADS Recombinant Protein – Cat# MBS143508

Acyl-Coenzyme A Dehydrogenase (ACADS) Human Recombinant Protein

Name: ACADS Recombinant Protein; Acyl-Coenzyme A Dehydrogenase; Human; MyBioSource
Brand: MyBioSource
SKU: MBS143508
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143508

Description: ACADS Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 409 amino acids (25-412 a.a.) and having a molecular mass of 44 kDa. The ACADS protein is fused to a 20 amino acid His Tag at N-terminus and… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Acyl-Coenzyme A Dehydrogenase (ACADS), Recombinant Protein

Full Product Name

Recombinant Human Acyl-Coenzyme A Dehydrogenase, C-2 to C-3

Product Gene Name

ACADS recombinant protein

Product Synonym Names

ACADS Human; Acyl-Coenzyme A Dehydrogenase C-2 to C-3 Human Recombinant; ACAD3; SCAD; EC 1.3.99.2; Short-chain specific acyl-CoA dehydrogenase; mitochondrial; Butyryl-CoA dehydrogenase; ACADS

Sequence

MGSSHHH HHH SSGLVPRGSH MLHTIYQSVE LPETHQMLLQ TCRDFAEKEL FPIAAQVDKE HLFPAAQVKK MGGLGLLAMD VPEELGGAGL DYLAYAIAME EISRGCASTG VIMSVNNSLY LGPILKFGSK EQKQAWVTPF TSGDKIGCFA LSEPGNGSDA GAASTTARAE GDSWVLNGTK AWITNAWEAS AAVVFASTDR ALQNKSISAF LVPMPTPGLT LGKKEDKLGI RGSSTANLIF EDCRIPKDSI LGEPGMGFKI AMQTLDMGRI GIASQALGIA QTALDCAVNY AENRMAFGAP LTKLQVIQFK LADMALALES ARLLTWRAAM LKDNKKPFIK EAAMAKLAAS EAATAISHQA IQILGGMGYV TEMPAERHYR DARITEIYEG TSEIQRLVIA GHLLRSYRS

Host

E Coli

Form/Format

The protein contains 20mM Tris buffer pH-8, 1mM DTT, 20% glycerol and 100mM NaCl.
Sterile filtered colorless solution.

Purity/Purification

Greater than 95.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Molecular Weight

44,297 Da

OMIM

201470

3D Structure

ModBase 3D Structure for P16219

Product Categories/Family for ACADS recombinant protein

Enzymes; Dehydrogenase

Other Notes

Small volumes of ACADS recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ACADS purchase

MBS143508 is a recombinant protein targeting ACADS. Also known as Recombinant Human Acyl-Coenzyme A Dehydrogenase, C-2 to C-3. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for ACADS. It may not necessarily be applicable to this product.

NCBI GI #

4557233

NCBI GeneID

NCBI Accession #

NP_000008.1

UniProt Primary Accession #

P16219

UniProt Secondary Accession #

P78331

UniProt Related Accession #

P16219

GenBank Nucleotide #

NM_000017.3

NCBI Official Full Name

short-chain specific acyl-CoA dehydrogenase, mitochondrial isoform 1

NCBI Official Synonym Full Names

acyl-CoA dehydrogenase, C-2 to C-3 short chain

NCBI Official Symbol

ACADS

NCBI Official Synonym Symbols

SCAD; ACAD3

UniProt Protein Name

Short-chain specific acyl-CoA dehydrogenase, mitochondrial

UniProt Synonym Protein Names

Butyryl-CoA dehydrogenase

Protein Family

Short-chain specific acyl-CoA dehydrogenase

UniProt Gene Name

ACADS

UniProt Synonym Gene Names

SCAD

UniProt Entry Name

ACADS_HUMAN

NCBI Protein Information

short-chain specific acyl-CoA dehydrogenase, mitochondrial; acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain; butyryl-CoA dehydrogenase; mitochondrial short-chain specific acyl-CoA dehydrogenase; unsaturated acyl-CoA reductase

NCBI Summary for ACADS

This gene encodes a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations in this gene have been associated with short-chain acyl-CoA dehydrogenase (SCAD) deficiency. Alternative splicing results in two variants which encode different isoforms. [provided by RefSeq, Oct 2014]

UniProt Comments for ACADS

ACADS: Defects in ACADS are the cause of acyl-CoA dehydrogenase short-chain deficiency (ACADSD). It is an autosomal recessive disorder resulting in acute acidosis and muscle weakness in infants, and a form of lipid-storage myopathy in adults. Belongs to the acyl-CoA dehydrogenase family.

Protein type: EC 1.3.8.1; Lipid Metabolism - fatty acid; Carbohydrate Metabolism - butanoate; Mitochondrial; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Oxidoreductase

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial membrane; nucleus

Molecular Function: acyl-CoA dehydrogenase activity; butyryl-CoA dehydrogenase activity; FAD binding; acyl-CoA binding

Biological Process: response to starvation; fatty acid beta-oxidation; response to glucocorticoid stimulus; cellular lipid metabolic process; fatty acid beta-oxidation using acyl-CoA dehydrogenase; butyrate catabolic process; protein homotetramerization

Disease: Acyl-coa Dehydrogenase, Short-chain, Deficiency Of

Research Articles on ACADS

1. Thirteen proteins had significant alteration in protein levels in patients carrying variation c.319C>T in ACADS compared to controls and they belonged to various pathways, such as the antioxidant system and amino acid metabolism.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ACADS recombinant protein

Reference Product	PubMed Publications
ECHS1 recombinant protein	>3 publications with ACADS and ECHS1
ACAA2 recombinant protein	>2 publications with ACADS and ACAA2
ACSM3 recombinant protein	>1 publications with ACADS and ACSM3
GCDH recombinant protein	>1 publications with ACADS and GCDH
ACAT2 recombinant protein	>1 publications with ACADS and ACAT2
EHHADH recombinant protein	>1 publications with ACADS and EHHADH
ACAT1 recombinant protein	>1 publications with ACADS and ACAT1

Pathways associated with ACADS recombinant protein

Products by Pathway	Pathway Diagram
Beta Oxidation Of Butanoyl-CoA To Acetyl-CoA Pathway antibodies	Beta Oxidation Of Butanoyl-CoA To Acetyl-CoA Pathway Diagram
Beta Oxidation Of Hexanoyl-CoA To Butanoyl-CoA Pathway antibodies	Beta Oxidation Of Hexanoyl-CoA To Butanoyl-CoA Pathway Diagram
Butanoate Metabolism Pathway antibodies	Butanoate Metabolism Pathway Diagram
Butanoate Metabolism Pathway antibodies	Butanoate Metabolism Pathway Diagram
Carbon Metabolism Pathway antibodies	Carbon Metabolism Pathway Diagram
Carbon Metabolism Pathway antibodies	Carbon Metabolism Pathway Diagram
Fatty Acid Beta Oxidation Pathway antibodies	Fatty Acid Beta Oxidation Pathway Diagram
Fatty Acid Degradation Pathway antibodies	Fatty Acid Degradation Pathway Diagram
Fatty Acid Degradation Pathway antibodies	Fatty Acid Degradation Pathway Diagram
Fatty Acid Metabolism Pathway antibodies	Fatty Acid Metabolism Pathway Diagram

Diseases associated with ACADS recombinant protein

Disease Name	Pubmed Publications
Short chain Acyl CoA dehydrogenase deficiency Antibodies	>9 publications with ACADS and Short chain Acyl CoA dehydrogenase deficiency
Fatty Liver Antibodies	>6 publications with ACADS and Fatty Liver
Liver Diseases Antibodies	>5 publications with ACADS and Liver Diseases
Brain Diseases Antibodies	>4 publications with ACADS and Brain Diseases
Nervous System Diseases Antibodies	>2 publications with ACADS and Nervous System Diseases
Heart Diseases Antibodies	>2 publications with ACADS and Heart Diseases
Fatty Liver, Alcoholic Antibodies	>1 publications with ACADS and Fatty Liver, Alcoholic
Disease Models, Animal Antibodies	>1 publications with ACADS and Disease Models, Animal
Hyperplasia Antibodies	>1 publications with ACADS and Hyperplasia
Kidney Diseases Antibodies	>1 publications with ACADS and Kidney Diseases

Organs/Tissues associated with ACADS recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>11 publications with ACADS and Liver
Muscle Antibodies	>8 publications with ACADS and Muscle
Brain Antibodies	>7 publications with ACADS and Brain
Blood Antibodies	>6 publications with ACADS and Blood
Kidney Antibodies	>3 publications with ACADS and Kidney
Connective Tissue Antibodies	>3 publications with ACADS and Connective Tissue
Nerve Antibodies	>2 publications with ACADS and Nerve
Prostate Antibodies	>1 publications with ACADS and Prostate
Skin Antibodies	>1 publications with ACADS and Skin
Intestine Antibodies	>1 publications with ACADS and Intestine