Mouse mIL 22 PEG Active Protein – Cat# MBS143524

Interleukin-22 (mIL 22 PEG) Mouse Active Protein

Name: mIL 22 PEG Active Protein; Interleukin-22; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS143524
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143524

Description: Pegylated Interleukin-22 Mouse Recombinant produced in E Coli is a single, non-glycosylated homodimeric polypeptide chain containing 147 amino acids and an aditional Ala amino acid at N-terminus having a molecular mass of 36 kDa as determioned by… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Interleukin-22 (mIL 22 PEG), Active Protein

Full Product Name

Recombinant Mouse Interleukin-22, Pegylated

Product Gene Name

mIL 22 PEG active protein

Product Synonym Names

IL 22 Mouse, PEG; Interleukin-22 Mouse Recombinant, Pegylated; IL-TIF; TIFa; IL-10-related T-cell-derived-inducible factor; IL-22; ILTIF; IL-D110; zcyto18; MGC79382; MGC79384; TIFIL-23

Host

E Coli

Form/Format

Lyophilized from a concentrated solution at 0.65mg/ml containing 0.003mM NaHCO3.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 98.0% as determined by: (a) Analysis by Gel-Filtration. (b) Analysis by SDS-PAGE.

Preparation and Storage

Lyophilized pegylated murine IL22 although stable at room temperature for several days, should be stored desiccated below -20 degree C. Upon reconstitution at 0.1mg/ml pegylated mouse IL22 and up to 2mg/ml, filter and sterilized, the protein can be stored at 4 degrees Celsius for several weeks making it suitable for long term infusion studies using osmotic pumps. At lower concentration addition of a carrier protein (0.1% HSA or BSA) is suggested. Please prevent freeze-thaw cycles.

Molecular Weight

20,106 Da

3D Structure

ModBase 3D Structure for Q9JJY9

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility

It is recommended to reconstitute the lyophilized pegylated mouse Interleukin -22 in sterile 0.4% NaHCO3 adjusted to pH 8-9 not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Biological Activity

The ED50 as determined by STAT3 phosphorylation assay in HepG cells. The activity in vitro was found to be ~ 10% compared to the non-pegylated mouse IL22.

Product Categories/Family for mIL 22 PEG active protein

Cytokines and Growth Factors; Cytokines; Interleukin

Other Notes

Small volumes of mIL 22 PEG active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for mIL 22 PEG purchase

MBS143524 is an active protein targeting mIL 22 PEG. Also known as Recombinant Mouse Interleukin-22, Pegylated. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for mIL 22 PEG. It may not necessarily be applicable to this product.

NCBI GI #

8393605

NCBI GeneID

50929

NCBI Accession #

NP_058667.1

UniProt Primary Accession #

Q9JJY9

UniProt Secondary Accession #

Q14BB3

UniProt Related Accession #

Q9JJY9

GenBank Nucleotide #

NM_016971.2

NCBI Official Full Name

interleukin-22

NCBI Official Synonym Full Names

interleukin 22

NCBI Official Symbol

Il22

NCBI Official Synonym Symbols

IL-22; Iltif; IL-22a; ILTIFa

UniProt Protein Name

Interleukin-22

UniProt Synonym Protein Names

IL-10-related T-cell-derived-inducible factor; IL-TIF; IL-TIF alpha; Interleukin-22a; IL-22a

Protein Family

Interleukin-22 receptor

UniProt Gene Name

Il22

UniProt Synonym Gene Names

Il22a; Iltif; Iltifa; IL-22; IL-TIF; IL-22a

UniProt Entry Name

IL22_MOUSE

NCBI Protein Information

interleukin-22; IL-10-related T-cell-derived-inducible factor; IL-TIF alpha; ILTIF alpha; interleukin 10-related T cell-derived inducible factor; interleukin-22a

UniProt Comments for mIL 22 PEG

IL22: Cytokine that contributes to the inflammatory response in vivo. Belongs to the IL-10 family.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; cytokine activity

Biological Process: negative regulation of inflammatory response; regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of transcription from RNA polymerase II promoter

Research Articles on mIL 22 PEG

1. Th1/Th2 and Th17 cells producing IL-22 are found in Leishmania resistant mice but not Balb c mice with draining lesions.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with mIL 22 PEG active protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Inflammatory Bowel Disease (IBD) Pathway antibodies	Inflammatory Bowel Disease (IBD) Pathway Diagram
Inflammatory Bowel Disease (IBD) Pathway antibodies	Inflammatory Bowel Disease (IBD) Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram

Diseases associated with mIL 22 PEG active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>26 publications with mIL 22 PEG and Inflammation
Immune System Diseases Antibodies	>13 publications with mIL 22 PEG and Immune System Diseases
Colitis Antibodies	>6 publications with mIL 22 PEG and Colitis
Lung Diseases Antibodies	>6 publications with mIL 22 PEG and Lung Diseases
Disease Models, Animal Antibodies	>5 publications with mIL 22 PEG and Disease Models, Animal
Weight Loss Antibodies	>2 publications with mIL 22 PEG and Weight Loss
Necrosis Antibodies	>2 publications with mIL 22 PEG and Necrosis
Liver Diseases Antibodies	>2 publications with mIL 22 PEG and Liver Diseases
Hypersensitivity Antibodies	>2 publications with mIL 22 PEG and Hypersensitivity
Fever Antibodies	>2 publications with mIL 22 PEG and Fever

Organs/Tissues associated with mIL 22 PEG active protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>3 publications with mIL 22 PEG and Brain