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Interleukin-15 (mIL 15) Mouse Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143557

Description: Interleukin-15 Mouse Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 152 amino acids (49-162 a.a.) and having a molecular mass of 17.6 kDa. The IL-15 is fused to a 37 amino acid His Tag at N-terminus and… More details

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Product Documentation
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Interleukin-15 (mIL 15), Active Protein
Full Product Name
Recombinant Mouse Interleukin-15, His Tag
Product Gene Name
mIL 15 active protein
Product Synonym Names
IL 15 Mouse, His; Interleukin-15 Mouse Recombinant, His Tag; IL-15; MGC9721; Interleukin-15; Il15; AI503618; mIL 15 His
Sequence
MRGSHHH HHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMNW IDVRYDLEKI ESLIQSIHID TTLYTDSDFH PSCKVTAMNC FLLELQVILH EYSNMTLNET VRNVLYLANS TLSSNKNVAE SGCKECEELE EKTFTEFLQS FIRIVQMFIN TS
Host
E Coli
Form/Format
The mouse IL-15 protein solution contains PBS, pH-7.4 and 10% glycerol.
Sterile filtered colorless solution.
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Molecular Weight
18,593 Da
3D Structure
ModBase 3D Structure for P48346
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
Measured in a cell proliferation assay using CTLL2 mouse cytotoxic T cells. The ED50 for this effect is < 1 ng/ml, corresponding to a specific activity of 1,000,000IU/mg.

Product Categories/Family for mIL 15 active protein

Cytokines and Growth Factors; Cytokines; Interleukin

Other Notes

Small volumes of mIL 15 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for mIL 15 purchase

MBS143557 is an active protein targeting mIL 15. Also known as Recombinant Mouse Interleukin-15, His Tag. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for mIL 15. It may not necessarily be applicable to this product.

NCBI GI #
363000984
NCBI GeneID
16168
NCBI Accession #
NP_001241676.1
UniProt Primary Accession #
P48346
UniProt Related Accession #
P48346
GenBank Nucleotide #
NM_001254747.1
NCBI Official Full Name
interleukin-15
NCBI Official Synonym Full Names
interleukin 15
NCBI Official Symbol
Il15
NCBI Official Synonym Symbols
IL-15; AI503618
UniProt Protein Name
Interleukin-15
Protein Family
Interleukin-15 receptor
UniProt Gene Name
Il15
UniProt Synonym Gene Names
IL-15
UniProt Entry Name
IL15_MOUSE
NCBI Protein Information
interleukin-15

UniProt Comments for mIL 15

IL15: Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha. Belongs to the IL-15/IL-21 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Secreted, signal peptide; Cell cycle regulation; Secreted

Cellular Component: nucleoplasm; extracellular space; cell surface; cytoplasm; extracellular region

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor binding; cytokine activity

Biological Process: positive regulation of interleukin-17 production; NK T cell proliferation; positive regulation of immune response; positive regulation of natural killer cell proliferation; negative regulation of smooth muscle cell proliferation; cell maturation; signal transduction; lymph node development; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of natural killer cell differentiation; extrathymic T cell selection; natural killer cell differentiation; positive regulation of cell proliferation; positive regulation of T cell proliferation; immune response; regulation of T cell differentiation; regulation of defense response to virus by host; hyaluronan metabolic process
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Research Articles on mIL 15

1. This study suggests that CCL20/IL-15 can induce a strong antitumor immune response in tumor tissues and it is a suitable candidate for cancer immunotherapy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with mIL 15 active protein

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response (BioCarta) Pathway antibodies  Cytokines And Inflammatory Response (BioCarta) Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram

Diseases associated with mIL 15 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >357 publications with mIL 15 and Inflammation
 Necrosis Antibodies  >341 publications with mIL 15 and Necrosis
 Disease Models, Animal Antibodies  >176 publications with mIL 15 and Disease Models, Animal
 Gastrointestinal Diseases Antibodies  >150 publications with mIL 15 and Gastrointestinal Diseases
 Nervous System Diseases Antibodies  >101 publications with mIL 15 and Nervous System Diseases
 Lung Diseases Antibodies  >100 publications with mIL 15 and Lung Diseases
 Neoplasms, Experimental Antibodies  >97 publications with mIL 15 and Neoplasms, Experimental
 Hematologic Diseases Antibodies  >88 publications with mIL 15 and Hematologic Diseases
 Celiac Disease Antibodies  >72 publications with mIL 15 and Celiac Disease
 Liver Diseases Antibodies  >56 publications with mIL 15 and Liver Diseases

Organs/Tissues associated with mIL 15 active protein

 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >180 publications with mIL 15 and Bone Marrow
 Spleen Antibodies  >173 publications with mIL 15 and Spleen
 Intestine Antibodies  >160 publications with mIL 15 and Intestine
 Liver Antibodies  >112 publications with mIL 15 and Liver
 Skin Antibodies  >99 publications with mIL 15 and Skin
 Joint Antibodies  >89 publications with mIL 15 and Joint
 Thymus Antibodies  >75 publications with mIL 15 and Thymus
 Kidney Antibodies  >72 publications with mIL 15 and Kidney
 Brain Antibodies  >58 publications with mIL 15 and Brain
 Heart Antibodies  >46 publications with mIL 15 and Heart
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